Schistosomiasis haematobia (Schistosomiasis haematobium)

A human disease caused by the infection of parasitic worms SCHISTOSOMA HAEMATOBIUM. It is endemic in AFRICA and parts of the MIDDLE EAST. Tissue damages most often occur in the URINARY TRACT, specifically the URINARY BLADDER.

Also Known As:

Networked: 211 relevant articles (22 outcomes, 22 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Infection
2.	Body Weight (Weight, Body)
3.	Schistosomiasis (Bilharziasis)
4.	Schistosomiasis japonica
5.	Proteinuria

Experts

1.	Rollinson, David: 5 articles (10/2009 - 02/2006)
2.	Stothard, J Russell: 4 articles (10/2009 - 02/2006)
3.	Brindley, Paul J: 3 articles (01/2014 - 03/2008)
4.	Khamis, I Simba: 3 articles (10/2009 - 10/2007)
5.	Arinola, O G: 3 articles (03/2005 - 12/2002)
6.	Olliaro, Piero L: 2 articles (11/2014 - 01/2014)
7.	Gomes, Paula: 2 articles (01/2014 - 01/2013)
8.	Botelho, Mónica C: 2 articles (01/2014 - 01/2013)
9.	Gouveia, Maria João: 2 articles (01/2014 - 01/2013)
10.	Vale, Nuno: 2 articles (01/2014 - 01/2013)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Schistosomiasis haematobia:

1.	Praziquantel (Biltricide)FDA Link 11/01/2000 - "We examined the long-term efficacy of praziquantel against Schistosoma haematobium, the causative agent of urinary schistosomiasis, during a school-based treatment program in the Msambweni area of Coast Province, Kenya, where the disease is highly endemic. " 04/01/2012 - "It was concluded that drug treatment with Praziquantel, especially when combined with Health Education was effective in reducing the prevalence of Urinary Schistosomiasis among school-aged children in Langai Community of Plateau State." 01/01/1981 - "Praziquantel appears to be an effective, well tolerated and easily administrable schistosomicide and thus a favourable contribution to the control of urinary schistosomiasis." 07/01/2005 - "In this study, we demonstrated a low efficacy of praziquantel in the treatment of schistosomiasis haematobia, and the necessity of the urinary bladder biopsy as criterion of cure." 05/01/1989 - "To assess the efficacy of low dose praziquantel regimens in comparison with standard 40 mg/kg dosing in the treatment of urinary schistosomiasis, a random allocation dose-finding trial was performed in children and adults from a Schistosoma haematobium endemic region in Coast Province, Kenya. "
2.	Trichlorfon (Metrifonate)IBA 01/01/1988 - "Efficacy of metrifonate in a highly endemic area of urinary schistosomiasis in Kenya." 11/01/1982 - "Efficacy of metrifonate in urinary schistosomiasis: comparison of reduction of Schistosoma haematobium and S. " 11/01/2009 - "The review confirmed that both the standard recommended doses of PZQ (single 40 mg/kg oral dose) and metrifonate (3x7.5-10 mg/kg oral doses administered fortnightly) are efficacious and safe in treating urinary schistosomiasis, but there is no study comparing these two regimens head-to-head. " 06/01/1991 - "During 1989 a survey for urinary schistosomiasis was carried out in children attending Kanhukamwe primary school where, 5 years previously, infected children had been treated with a single dose of metrifonate. " 06/01/1991 - "Long-term effects of single-dose metrifonate on the control of urinary schistosomiasis in an endemic area."
3.	artesunateIBA 07/01/2004 - "Efficacy of artesunate in the treatment of urinary schistosomiasis, in an endemic community in Nigeria." 11/01/2012 - "The role of artesunate for the treatment of urinary schistosomiasis in schoolchildren: a systematic review and meta-analysis." 07/01/2004 - "The efficacy and tolerability of oral artesunate for the treatment of urinary schistosomiasis was assessed among schoolchildren aged 5-18 years in Adim community, Nigeria. " 01/01/2009 - "Efficacy of a combination of praziquantel and artesunate in the treatment of urinary schistosomiasis in Nigeria." 01/01/2009 - "This study confirmed that the treatment of urinary schistosomiasis with the combination of praziquantel and artesunate is safe and more effective than treatment with either drug alone."
4.	mirazidIBA 12/01/2003 - "So, Mirazid in a dose of two capsules (600 mgm) on an empty stomach before breakfast for six successive days proved to be very effective and safe in the treatment of schistosomiasis haematobium." 12/01/2003 - "This study evaluated the efficacy of Mirazid (Commiphora molmol) in the treatment of parasitologically and clinically and ultrasonography confirmed cases of schistosomiasis haematobium in Tatoon village. " 12/01/2003 - "Clinical and parasitological studies on the efficacy of Mirazid in treatment of schistosomiasis haematobium in Tatoon, Etsa Center, El Fayoum Governorate." 12/01/2003 - "Out of the 62 schistosomiasis haematobium patients, 57 (91.9%) were cured after two months follow up and the cure rate reached 59 (95.2%) on the 3rd month post-Mirazid treatment. " 08/01/2004 - "A field survey was done in Ezbet El-Bakly (Tamyia Center) El-Fayoum Governorate to determine the magnitude of schistosomiasis haematobium and mansoni and to evaluate the efficacy of Mirazid (the oleo-resin extract from Myrrh of Commiphora molmol tree, family: Burseraceae) in the treatment of both types of schistosomiasis. "
5.	Reagent StripsIBA 04/01/2014 - "This study assessed the validity of a morbidity questionnaire and urine reagent strips as a rapid tool for screening schoolchildren for urinary schistosomiasis as compared with the presence of eggs in urine as the gold-standard parasitological diagnosis. " 01/01/2000 - "We therefore undertook a study in an area endemic for Schistosoma haematobium in the United Republic of Tanzania to carry out the following: assess the sensitivity, specificity and predictive values--in women of childbearing age--of indirect indicators of urinary schistosomiasis, as measured by urine reagent strip readings; assess the predictive values of self-reported symptoms; and finally to estimate the morbidity attributable to S. " 12/01/1997 - " The present study evaluated the diagnostic potential of 3 indirect tests for urinary schistosomiasis in 1056 children and adults from Nigeria's Kainji Lake area: interview technique, visual examination for macrohematuria, and use of a chemical reagent strip. " 12/01/2009 - "The performance of haematuria reagent strips for the rapid mapping of urinary schistosomiasis: field experience from Southern Sudan." 08/01/2009 - "From a control perspective, Microalbustix reagent strips are therefore best applied in pre-screening protocols allowing selection, or rather confident exclusion, of schoolchildren with urinary schistosomiasis for more detailed investigations."
6.	artemisinine (artemisinin)IBA 11/01/2012 - "Efficacy of artemisinin derivatives alone or in combination compared to praziquantel alone for the treatment of urinary schistosomiasis in schoolchildren. " 11/01/2012 - "Randomized clinical trials comparing praziquantel with artemisinin derivatives in the treatment of urinary schistosomiasis in schoolchildren were included. " 01/01/2008 - "Randomized and quasi-randomized controlled trials of praziquantel, metrifonate, artemisinin derivatives, or albendazole, alone or in combination, versus placebo, different doses, or other antischistosomal drugs for treating urinary schistosomiasis. "
7.	oltiprazIBA 06/01/1984 - "The oral treatment of urinary schistosomiasis in Egyptian patients with 'Oltipraz'." 03/01/1982 - "Oltipraz thus appears to be a most interesting drug for urinary schistosomiasis" 06/01/1984 - "Comparative trial of oltipraz versus praziquantel in the treatment of urinary schistosomiasis in the Gabon." 11/01/1983 - "As far as schistosomiasis haematobium is concerned, oltipraz and praziquantel have a 87,5% success rate with oltipraz and 80% with praziquantel; however, in the case of oltipraz , it is necessary to increase the dose. " 06/01/1984 - "The efficacy of oltipraz as a schistosomicidal drug was investigated in Gabonese children suffering from urinary schistosomiasis in the dosages of 1 X 25 mg/kg body weight, 1 X 35 mg/kg body weight, and 2 X 20 mg/kg body weight and compared to praziquantel, 2 X 30 mg/kg body weight. "
8.	NiridazoleIBA 10/06/1969 - "Efficacy of niridazole in schistosomiasis haematobium." 10/01/1986 - "Influence of the dosing interval on the response of urinary schistosomiasis to therapy with niridazole." 07/01/1986 - "The side-effects of niridazole used for urinary schistosomiasis were studied prospectively over a 3-month period in male patients receiving the standard dose of 25 mg day-1 kg-1 for 7 days. " 05/01/1981 - "I.) investigations in the post-therapeutical course of the urinary schistosomiasis was carried out in a group of 25 patients treated with niridazole and on a group of 25 patients treated with 35 972 RP. " 01/01/1970 - "Urinary schistosomiasis treated with niridazole (Ambilhar): a quantitative evaluation."
9.	Lysophospholipase (Phospholipase B)IBA 03/01/2008 - "Schistosome lysophospholipase may represent a new target for anti-schistosomal chemotherapy given that metrifonate, which targets the related enzyme acetylcholinesterase, is an effective and safe medicine for treatment of urinary schistosomiasis."
10.	Cholinesterases (Cholinesterase)IBA 06/01/1981 - "Metrifonate, an organophosphorus cholinesterase inhibitor, which has been shown to be effective in the treatment of urinary schistosomiasis was administered orally to 145 school children aged 6-15 years at a dose of 10 mg/kg body weight in 3 doses at 14-day intervals. "

Therapies and Procedures

1.	Drug Therapy (Chemotherapy) 09/01/2002 - "The transmission biology of urinary schistosomiasis in Zanzibar is reviewed, the paper reports on ongoing malacological studies in Zanzibar and Kenya and finally closes by posing the question whether medical malacology forms an essential component associated with mass-scale chemotherapy control programmes." 09/01/1997 - "A school- and chemotherapy-based urinary schistosomiasis and intestinal helminth infection control programme was conducted in Matuga Division, Kwale District, Coast Province with teachers taking care of diagnosis, treatment and health education. " 04/01/1995 - "Strict control measures, including mass chemotherapy and mollusciciding, were used to help reduce the prevalence of urinary schistosomiasis. " 01/01/1992 - "Age-targeted chemotherapy for control of urinary schistosomiasis in endemic populations." 10/01/1991 - "Chemotherapy-based control of schistosomiasis haematobia. "
2.	Aftercare (After-Treatment) 01/01/1987 - "Resistance to reinfection after treatment of urinary schistosomiasis." 07/30/1999 - "At Diagambal, where the two parasites were present before treatment, the disappearance of the urinary schistosomiasis after treatment concurred with a dramatic increase of intestinal schistosomiasis. " 10/01/1986 - "It was concluded that, in children, the resolution of bladder lesions induced by urinary schistosomiasis resulted in reversibility of urinary tract obstructions one year after treatment with Praziquantel." 10/01/1984 - "[Course of urinary schistosomiasis over 3 consecutive years after treatment with metrifonate in a dry savanna village in Upper Volta]." 09/01/1982 - "[Value of macroscopic urine examination and reagent strips for the detection of hematuria and proteinuria in the mass diagnosis of urinary schistosomiasis, before and after treatment]."
3.	Kidney Transplantation 03/01/1993 - "Re: Urological complications following live donor kidney transplantation: effect of urinary schistosomiasis." 09/01/1992 - "Urological complications following live donor kidney transplantation: effect of urinary schistosomiasis."
4.	Retreatment 06/01/1999 - "Community-based treatment is recommended for endemic populations with urinary schistosomiasis; however, the optimal target group for treatment and retreatment interval have not been established. "
5.	Immunotherapy 03/01/1995 - "Keyhole-limpet hemocyanin was used for its ability to prevent tumor recurrence and because of its similarity to schistosomal antigen for intravesical specific immunotherapy in 13 patients with superficial transitional cell bladder tumors (Ta, Tis, T1) associated with urinary schistosomiasis. "