Scabies (Sarcoptic Mange)

A contagious cutaneous inflammation caused by the bite of the mite SARCOPTES SCABIEI. It is characterized by pruritic papular eruptions and burrows and affects primarily the axillae, elbows, wrists, and genitalia, although it can spread to cover the entire body.

Also Known As:

Networked: 795 relevant articles (95 outcomes, 95 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Infection
2.	Body Weight (Weight, Body)
3.	Lice Infestations (Pediculosis)
4.	Pruritus (Itching)
5.	Mite Infestations (Mange)

Experts

1.	Currie, Bart J: 23 articles (12/2015 - 01/2003)
2.	Walton, Shelley F: 19 articles (03/2015 - 01/2003)
3.	Fischer, Katja: 16 articles (09/2014 - 12/2003)
4.	Arlian, Larry G: 13 articles (10/2015 - 01/2003)
5.	Holt, Deborah C: 13 articles (10/2015 - 01/2003)
6.	Goldust, Mohamad: 13 articles (01/2015 - 01/2012)
7.	Morgan, Marjorie S: 12 articles (10/2015 - 12/2003)
8.	Rezaee, Elham: 11 articles (12/2014 - 01/2012)
9.	Kemp, David J: 11 articles (01/2012 - 01/2003)
10.	McCarthy, James: 8 articles (10/2015 - 04/2006)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Scabies:

1.	Ivermectin (Mectizan)FDA Link 07/01/1999 - "We describe a case of crusted scabies, induced by long-term application of a topical corticosteroid, relapsing after topical treatment and dramatically improved by ivermectin. " 01/01/2001 - "To study the efficacy of ivermectin for scabies, which is very common in Colombia, a trial with this drug that could be easily administered, with fast application and high efficacy, was undertaken. " 11/01/1998 - "The advantages of oral ivermectin treatment in scabies patients are: high therapeutic efficacy against Sarcoptes scabiei, good tolerance and influence of the drug on the whole skin surface and on clinical symptoms. " 03/01/1998 - "All patients were successfully cured of scabies with a twice oral dose of 200 microg/kg ivermectin within 8 days. " 01/01/1998 - "The authors conclude that ivermectin is effective for crusted scabies; however, multiple doses may be required to achieve a cure, and recurrence 6 or more weeks after completing treatment is common."
2.	Permethrin (Ambush)FDA LinkGeneric 01/01/2007 - "Topical permethrin appears to be the most effective treatment for scabies. " 09/01/2003 - "In the opinion of the author, 5% permethrin is the best treatment for scabies in infants and young children." 11/01/1986 - "Permethrin 5% dermal cream: a new treatment for scabies." 01/01/2013 - "This study aimed at comparing the efficacy of permethrin 2.5% cream vs. Tenutex emulsion for the treatment of scabies. " 09/15/2012 - "First-line treatment of scabies is topical permethrin 5% cream. "
3.	Lindane (gamma-Hexachlorocyclohexane)FDA LinkGeneric 09/01/2000 - "Those who were not cured were then treated with 1% lindane lotion topically, as were the prison staff who had scabies. " 11/01/1986 - "Only three of twenty-three (13%) patients treated with 1% lindane lotion (Kwell) were free of scabies 2 weeks after a single treatment and fifteen of twenty-three (65%) were cured at 1 month. " 10/01/1983 - "A trial of three treatment schedules, consisting of 1% gamma benzene hexachloride (GBH) lotion applied head to toe and left on the body for 2, 6, or 12 to 24 hours was conducted on an island of 2,076 persons, approximately 70% of whom had clinical evidence of scabies. " 08/01/2015 - "We suggest that a twice-weekly schedule (on consecutive days) of 1% lindane treatment lasting at least 2 weeks is required to clear scabies. " 08/01/2015 - "Efficacy and safety of a lindane 1% treatment regimen for scabies, confirmed by dermoscopy-guided skin scraping with microscopic examination."
4.	benzyl benzoate (Ansar)FDA Link 10/01/2009 - "It is concluded that Aloe vera gel is as effective as benzyl benzoate in the treatment of scabies." 01/01/1986 - "[Improvement in the method of treating scabies with benzyl benzoate]." 06/01/2014 - "[Treatment of scabies and Ascabiol(®) supply disruption: what about the pediatric population?]." 01/01/2011 - "Surprisingly, the histology of a skin lesion demonstrated the presence of scabies, which was successfully treated with benzyl benzoate 20%. " 01/01/2001 - "In Nigeria, 25% benzyl benzoate is being extensively used for the treatment of scabies in adults. "
5.	SulfurIBA 12/01/2003 - "Sulfur is effective for treating scabies outbreaks where the cost of treatment is a major concern. " 03/01/2012 - "Many therapeutic modalities for scabies were available, topical sulfur ointment is a cost-effective and safe therapeutic agent. " 03/01/1991 - "Therapeutic efficacy, secondary effects, and patient acceptability of 10% sulfur in either pork fat or cold cream for the treatment of scabies." 03/01/2012 - "Treatment of scabies using 8% and 10% topical sulfur ointment in different regimens of application." 06/01/2008 - "Topical sulfur preparations, with only limited usefulness, are the only available topical drugs approved by health insurance coverage for treating scabies. "
6.	Malathion (Karbofos)FDA LinkGeneric 03/01/1984 - "Prioderm lotion, given in one single topical application, proved to be an effective and safe drug for the treatment of scabies in most cases." 08/01/2009 - "Malathion is an under-recognized and under-utilized therapy for head lice and scabies largely due to misperceptions about its safety profile. " 08/01/2009 - "Malathion for head lice and scabies: treatment and safety considerations." 03/01/1984 - "Prioderm lotion in the treatment of scabies." 09/01/2014 - "Comparing the efficacy of oral ivermectin vs malathion 0.5% lotion for the treatment of scabies."
7.	milbemycin (moxidectin)IBA 01/01/2000 - "Moxidectin was found to be effective against ovine sarcoptic mange, when given twice; the percentage reduction of mites was 100% (p < 0.0001) and the skin lesions disappeared completely (p = 0.0001). " 12/10/2011 - "Efficacy of long-acting moxidectin against sarcoptic mange in naturally infested sheep." 01/01/2000 - "Efficacy of moxidectin against sarcoptic mange and effects on milk yield of ewes and growth of lambs." 01/01/2011 - "Moxidectin efficacy in a goat herd with chronic and generalized sarcoptic mange." 11/10/2000 - "Forty-one dogs suffering from sarcoptic mange were treated with 0.2-0.25mg/kg moxidectin either orally or subcutaneously every week for three to six times. "
8.	amitraz (Taktic)IBA 08/01/2007 - "Sarcoptic mange in three alpacas treated successfully with amitraz." 08/01/2007 - "In this small group of alpacas, amitraz was an effective and well-tolerated treatment for sarcoptic mange." 04/01/2001 - "Efficacy of 1.25% amitraz solution in the treatment of generalized demodicosis (eight cases) and sarcoptic mange (five cases) in dogs." 08/01/2007 - "As no drug is currently licensed for the treatment of sarcoptic mange in alpacas in the UK, they were treated with a topical solution of amitraz (50 mL in 10 L) after initial bathing with antibacterial or keratolytic shampoos. " 08/01/1984 - "A liquid concentrate formulation of amitraz (Mitaban: Upjohn) was used to topically treat 181 dogs with scabies, at an active drug level of 250 ppm, or 10.6 ml of concentrate in 2 gal water. "
9.	AntigensIBA 01/01/2003 - "This work shows that it is now possible to conduct such challenge trials with cloned scabies antigens." 12/01/1983 - "Critical studies using purified antigens from scabies mites in vivo and in vitro will be necessary in order to clarify the nature of the antigens involved and the role of different types of immune responses in producing clinical disease." 10/01/2015 - "No patient had serum antibody exclusively reactive to scabies mite antigens. " 01/01/2013 - "These data provide important information on the temporal development of humoral immune responses in scabies and further supports the development of recombinant antigen based immunodiagnostic tests for recent scabies infestations." 09/01/2010 - "Increased allergic immune response to Sarcoptes scabiei antigens in crusted versus ordinary scabies."
10.	crotamiton (Eurax)FDA LinkGeneric 03/01/1990 - "In a double-blinded, randomized study, it was compared with crotamiton 10% cream (Eurax) for the treatment of scabies in children 2 months to 5 years of age. " 05/01/2003 - "She developed common scabies, but a topical scabicide, crotamiton, was not effective. " 03/01/1995 - "We recommend that an antiscabietic drug should be followed by 3 days of crotamiton in the treatment of scabies." 09/01/1991 - "The persons with scabies were treated with crotamiton liniment. " 05/01/1988 - "Treatment of scabies with crotamiton."

Therapies and Procedures

1.	Drug Therapy (Chemotherapy) 04/01/2013 - "When properly administered, chemotherapy for scabies remains effective in most situations. " 01/01/2004 - "We report two children with scabies who were misdiagnosed clinically and histologically as LCH and treated with systemic chemotherapy. " 02/01/2001 - "Disseminated scabies evolving in a patient undergoing induction chemotherapy for acute myeloblastic leukaemia." 05/01/2007 - "Crusted Norwegian scabies in an adult with Langerhans cell histiocytosis: mishaps leading to systemic chemotherapy." 02/01/2001 - "This rash appeared on day 5 of the chemotherapy and was diagnosed as disseminated scabies. "
2.	Immunotherapy 06/16/2014 - "Improved coordination of care by health services, and research and development of new therapies including immunotherapies for crusted scabies, must be a priority." 11/01/2014 - "Given the potential of anti-IL-17 immunotherapy demonstrated for other inflammatory skin diseases, this study may provide a novel therapeutic avenue for patients with recurrent crusted scabies."
3.	Polypharmacy 09/23/2000 - "There was a significant and sustained reduction in polypharmacy and an improvement in the treatment of upper-respiratory infection, scabies, and anaemia. " 09/23/2000 - "Data on polypharmacy and appropriateness of the treatment of upper-respiratory infection, anaemia, and scabies from the 17 primary health-care units in northern Zanzibar were analysed before and after the teaching programme. "
4.	Rhizotomy 01/01/1981 - "They were all undergoing severe incident pains related to complications (scabies, osteoporosis, painful cough or colic, Charley-Horse, RX-necrosis of skin or mucous membranes, etc) in spite of having their chronic pain component cured: phanol-rhizotomy: two cases, neuro-adrenolysis by alcohol: four cases, Brampton mixture: three cases. "
5.	Home Nursing (Nursing, Home) 01/01/2015 - "Scabies does not manifest as a singular skin condition and may present atypically in older adults, the majority of nursing home residents, where delay has deleterious consequences. " 01/01/2015 - "Scabies has a predilection to infect vulnerable subsets of population in crowding conditions, typically applicable to residents in the nursing home. " 01/01/2015 - "Scabies in the nursing home." 01/01/2014 - "Scabies in the nursing home, misdiagnosis means costs, and embarrassment: story of a centenarian smitten by scabies!" 08/01/2012 - "To prevent scabies, proper management of the nursing home setting, including adequate cleaning of the contaminated clothing, bedding and equipment, in combination with treating all suspected scabies patients, and contact isolation are important and necessary."