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2-acetylhydrazide 8-chloro- Dibenz(b,f)(1,4)oxazepine- 10(11H)- carboxylic acid

Inhibits the activity of prostaglandins.

Also Known As:

Dibenz(b,f)(1,4)oxazepine-10(11H)-carboxylic acid, 8-chloro-, 2-acetylhydrazide; SC-19220

Networked: 13 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 3-Ring Heterocyclic Compounds
    - Dibenzoxazepines: 1
      - 2-acetylhydrazide 8-chloro- Dibenz(b,f)(1,4)oxazepine-10(11H)-carboxylic acid: 13
        pinadoline

Experts

1.	Jensen, Michael Schou: 1 article (01/2022)
2.	Kresse, Jean-Claude: 1 article (01/2022)
3.	Madsen, Mia Gebauer: 1 article (01/2022)
4.	Mutsaers, Henricus A M: 1 article (01/2022)
5.	Nejsum, Lene N: 1 article (01/2022)
6.	Nørregaard, Rikke: 1 article (01/2022)
7.	Praetorius, Helle: 1 article (01/2022)
8.	Tingskov, Stine Julie: 1 article (01/2022)
9.	Chakrabarti, Sumontra: 1 article (10/2003)
10.	Chakraborty, Chandan: 1 article (10/2003)

Related Diseases

1.	Bone Resorption 05/01/1999 - "Since 1,25(OH)2D3 has been shown to induce osteoclast formation through PGE2 synthesis, in this study we have examined the effect of SC-19220 on osteoclast formation induced by 1,25(OH)2D3 in cell cultures by measuring bone resorption as well as TRAP-positive cell formation. "
2.	Hyperthermia 07/01/1994 - "The PGE2 (0.3 nmol)-induced hyperthermia was blocked by LCV pretreatment with SC-19220 (150 nmol), an EP1 antagonist. " 10/01/1982 - "Indomethacin and SC-19220 (a PG antagonist) did not antagonize PGI2-induced hyperthermia. "
3.	Ganglion Cysts (Ganglion) 05/01/1970 - "With trains of ten or more pulses, response A is always larger than B; the ratio of A/B (1.2-21.3) is subject to animal variation.2. Both responses are abolished by tetrodotoxin and are absent from plexus-free preparations.3. Neither response is reduced by ganglion-block with (+)-tubocurarine, dimethyltubocurarine or hexamethonium, or by ganglion-paralysing doses of nicotine; the contribution of excited preganglionic endings to these responses is therefore negligible.4. Neither response is due to a release of histamine, 5-hydroxytryptamine (5-HT) or prostaglandins, since both A and B persist in the presence of mepyramine, methysergide and the prostaglandin-antagonist SC-19220 (1-acetyl-2(8-chloro-10,11-dihydrodibenz [b,f] [1,4]oxazepine-10-carbonyl) hydrazine).5. The two response-components are affected differentially by a number of drugs.6. Histamine, 0.1 mug/ml., reduces response A to the level of B; this selective inhibition of the histamine-sensitive component in A is specifically antagonized by nicotine, 1-2.5 x 10(-5) g/ml.7. 5-HT, 0.1 mug/ml., and strychnine, 20-40 mug/ml., also reduce response A to the level of B, but these selective inhibitions are not antagonized by nicotine.8. Diphenhydramine, 10 mug/ml., produces equality of the two responses by depressing A and potentiating B.9. The inhibitory effects of the foregoing drugs are not due to catecholamine release, since they persist after alpha + beta adrenoceptor blockade with phentolamine and pronethalol, and after previous reserpinization of the guinea-pigs.10. "
4.	Sepsis (Septicemia) 05/01/2000 - "A murine model of burn sepsis with and without treatment with SC-19220, a PGE2 receptor antagonist, was used to determine peripheral monocyte and neutrophil counts as well as the colony forming potential of colony-stimulating factor responsive bone marrow progenitors. "
5.	Hypothermia 03/01/1975 - "Although these results may indicate a role of prostaglandins in normal physiological thermoregulation, it is also possible that production of hypothermia by SC-19220 is unrelated to prostaglandin antagonism." 03/01/1975 - "Neither prostaglandin E-1 nor leukocytic pyrogen was antagonized when given shortly after recovery from SC-19220-induced hypothermia or by doses of SC-19220 which did not cause hypothermia. "

Related Drugs and Biologics

1.	Dinoprostone (PGE2)
2.	Calcitriol (Calcijex)
3.	Prostaglandins
4.	Indomethacin (Indometacin)
5.	Histamine (Histamine Dihydrochloride)
6.	Purinergic P1 Receptor Antagonists
7.	Hexamethonium (Hexamethonium Bromide)
8.	Tubocurarine (Tubocurarine Chloride)
9.	Tetrodotoxin (Tetradotoxin)
10.	Strychnine

Related Therapies and Procedures

1.	Subcutaneous Injections