Sarcocystosis

Infection of the striated muscle of mammals by parasites of the genus SARCOCYSTIS. Disease symptoms such as vomiting, diarrhea, muscle weakness, and paralysis are produced by sarcocystin, a toxin produced by the organism.

Also Known As:

Networked: 31 relevant articles (3 outcomes, 1 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Infection
2.	Parasitic Diseases (Parasitic Disease)
3.	Weight Gain
4.	Zygomycosis (Phycomycosis)
5.	Parasitemia

Experts

1.	Dubey, J P: 4 articles (04/2015 - 12/2000)
2.	Rosenthal, B M: 3 articles (04/2015 - 12/2000)
3.	Shen, S K: 3 articles (02/2001 - 12/2000)
4.	Kwok, O C: 3 articles (02/2001 - 12/2000)
5.	Lindsay, D S: 3 articles (02/2001 - 12/2000)
6.	Subramaniam, Vellayan: 1 article (11/2015)
7.	Ng, Yit Han: 1 article (11/2015)
8.	Lau, Yee Ling: 1 article (11/2015)
9.	Yang, Y: 1 article (04/2015)
10.	Calero-Bernal, R: 1 article (04/2015)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Sarcocystosis:

1.	AmproliumIBA 02/01/1980 - "The efficacy of amprolium against clinical sarcocystosis resulting from Sarcocystis ovicanis was determined in two experiments involving 40 lambs. " 02/01/1980 - "Data from deaths, body temperatures, weight gains, serum protein levels, hematocrits, hemoglobin values, LDH and SGOT values, postmortem examinations, and histological examinations indicated that amprolium at both levels tested reduced the number of deaths and severity of clinical signs of sarcocystosis in experimentally infected lambs as compared with unmedicated controls."
2.	salinomycinIBA 04/01/1983 - "Salinomycin, administered prophylactically, was effective in controlling clinical sarcocystosis resulting from infection with Sarcocystis ovicanis in two experiments involving a total of 50 lambs. " 04/01/1983 - "Data from deaths, weight gains, body temperatures, packed cell volumes, hemoglobin values, serum protein levels, and postmortem and histological examinations indicated that salinomycin at both doses tested reduced the number of deaths and severity of signs of sarcocystosis in infected lambs as compared with unmedicated controls. "
3.	halofuginoneIBA 01/01/1981 - "Halofuginone was most effective in the treatment of acute sarcosporidiosis at a dose of 0.67 mg/kg b. "
4.	Insulin-Like Growth Factor I (IGF-1)IBA 09/01/1991 - "In this article, Ron Foyer and Ted Elsosser use a bovine sarcocystosis model to show that changes in plasma concentrations of insulin-like growth factor-I (IGF-I), growth hormone (GH) and somotostotin (SSN), as well as the host's immunological response to the parasite via cytokine interactions with the endocrine system, are modulators of perturbed growth." 02/01/1988 - "A parasitic disease model (sarcocystosis) was used to study the effects of infection and associated plane of nutrition on GH and somatomedin-C (SM-C) patterns in plasma, and SM-C binding protein patterns in plasma from 4-month-old male Holstein calves. "
5.	Carrier Proteins (Binding Protein)IBA 02/01/1988 - "A parasitic disease model (sarcocystosis) was used to study the effects of infection and associated plane of nutrition on GH and somatomedin-C (SM-C) patterns in plasma, and SM-C binding protein patterns in plasma from 4-month-old male Holstein calves. "
6.	AntigensIBA 04/01/1994 - "Intact cystozoites extracted from naturally infected bovine flesh were used as an antigen to develop an ELISA for serodiagnosing sarcocystosis. " 02/01/1992 - "For the diagnostics of sarcocystosis by the ELISA technique used the sandwich test of the antibody titration with a soluble antigen which was also prepared from S. " 02/01/1983 - "Specific immuno-enzymatic assays for circulating Sarcocystis antigens may therefore prove useful in the clinical diagnosis of acute sarcocystosis." 01/01/1988 - "This immunosuppression was observed only when infection preceded immunization or when mice were immunized concurrently with infection, suggesting that suppression induced by murine sarcocystosis affected the induction and/or the differentiation of antigen-sensitive immunocytes. " 11/01/1981 - "Samples from 57.9% and 51.5% of goats showed positive serological reactions to the antigens for sarcosporidiosis and Q fever respectively."
7.	AntibodiesIBA 04/01/1991 - "Specific antibodies of sarcocystosis were detected in 94.44% of young animals. " 04/01/1991 - "In none of new-born lambs there were proved antibodies to the sarcocystosis before the drinking of colostrum but three days later we already detected antibodies in the dilution 1:4 to 1:128. " 04/01/1991 - "We studied the problems of sarcocystosis of lambs in regard to the transfer of antibodies over ewes to lambs. " 11/01/1985 - "Antibodies to sarcocystosis were determined in the blood serum by the indirect fluorescence method. " 01/01/1985 - "Despite the presence of specific antibodies at the time of challenge, all pigs died from acute sarcocystosis 12 days later. "
8.	Interferon-gamma (Interferon, gamma)IBA 02/26/2001 - "Interferon gamma gene knock out (KO) mice fed sporocysts from two opossums developed neurologic sarcocystosis. " 12/01/2000 - "Gamma interferon knockout mice fed sporocysts from experimentally infected opossums developed clinical sarcocystosis, and S. "
9.	Hemoglobins (Hemoglobin)IBA 04/01/1983 - "Data from deaths, weight gains, body temperatures, packed cell volumes, hemoglobin values, serum protein levels, and postmortem and histological examinations indicated that salinomycin at both doses tested reduced the number of deaths and severity of signs of sarcocystosis in infected lambs as compared with unmedicated controls. " 02/01/1980 - "Data from deaths, body temperatures, weight gains, serum protein levels, hematocrits, hemoglobin values, LDH and SGOT values, postmortem examinations, and histological examinations indicated that amprolium at both levels tested reduced the number of deaths and severity of clinical signs of sarcocystosis in experimentally infected lambs as compared with unmedicated controls."
10.	MicronutrientsIBA 06/01/2011 - "These findings may explain the role of copper, zinc and iron in parasite persistency and may discuss the pathogenesis of sarcocystosis, which relates to evocate mentioned micronutrient to cardiac muscle."

Therapies and Procedures

1.	Drug Therapy (Chemotherapy) 01/01/1981 - "The Sarcocystis muris-infection as a model for research on the chemotherapy of acute sarcocystosis of domestic animals." 01/01/1981 - "Chemotherapy of Sarcosporidiosis and theileriosis in domestic animals."
2.	Chemoprevention 06/01/1981 - "[Chemoprophylaxis and therapy of acute sarcosporidiosis]."