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Sarcosine (Methylglycine)

An amino acid intermediate in the metabolism of choline.

Also Known As:

Methylglycine; Magnesium Sarcosylate; N-Methylglycine; Sarcosine Hydrochloride; Sarcosine Monosodium Salt; Sodium Sarcosinate; N Methylglycine; Sarcosinate, Sodium; Sarcosylate, Magnesium; Glycine, N-methyl-

Networked: 143 relevant articles (10 outcomes, 33 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Lane, Hsien-Yuan: 8 articles (09/2014 - 03/2004)
2.	Strzelecki, Dominik: 6 articles (12/2015 - 01/2014)
3.	Tsai, Guochuan E: 6 articles (02/2012 - 11/2005)
4.	Kałużyńska, Olga: 5 articles (12/2015 - 01/2015)
5.	Zitka, Ondrej: 5 articles (01/2015 - 01/2013)
6.	Kizek, Rene: 5 articles (01/2015 - 01/2013)
7.	Adam, Vojtech: 5 articles (01/2015 - 01/2013)
8.	Chang, Yue-Cune: 5 articles (05/2010 - 11/2005)
9.	Kotlicka-Antczak, Magdalena: 4 articles (10/2015 - 01/2015)
10.	Koo, Ja Seung: 4 articles (05/2015 - 01/2014)

Related Diseases

1.	Schizophrenia (Dementia Praecox) 12/15/2015 - "This is the first randomized placebo-controlled study to examine the metabolic safety of sarcosine in patients with schizophrenia. " 12/15/2015 - "This study was undertaken with the purpose to determine if there are changes in metabolic parameters during 6-month add-on treatment with sarcosine in patients with schizophrenia. " 10/08/2015 - "This is the first study showing that a pharmacological intervention in schizophrenia, particularly augmentation of the antypsychotic treatment with sarcosine, may reverse the pathological increase in glutamatergic transmission in the hippocampus. " 10/08/2015 - "The aim of the study was to assess the effects of sarcosine on metabolism parameters in the left hippocampus in patients with schizophrenia. " 01/01/2015 - "Safety, tolerability and pharmacokinetics of open label sarcosine added on to anti-psychotic treatment in schizophrenia - preliminary study."
2.	Carcinoma (Carcinomatosis) 01/01/2015 - "Herein, we describe an ultrasensitive specific biosensing system for detection of sarcosine as a potential biomarker of prostate carcinoma based on Förster resonance energy transfer (FRET). " 11/01/1986 - "When the mice were intubated with a single dose of nitroso-sarcosine-ethylester (NSEE), the incidence of the forestomach carcinoma was only 9.5%. " 12/01/1991 - "In vivo, green tea extract decreased the incidence of carcinoma in the forestomach and esophagus of mice induced by sarcosine and NaNO2. " 04/01/2014 - "In this study, we monitored the abundance of potential non-invasive markers of prostate carcinoma such as amino acid sarcosine, involved in the metabolism of amino acids and methylation processes, ongoing during the progression of prostate carcinoma. " 08/01/2009 - "Uptake by Caco-2 cells (human carcinoma cell line) and HeLa cells transfected with peptide transporter 1 (HeLa/PEPT1) was time- and temperature-dependent and was inhibited by typical PEPT1 inhibitors such as glycyl-sarcosine (Gly-Sar). "
3.	Seizures (Seizure) 03/01/2010 - "Conversely, sarcosine showed weak anticonvulsant properties by increasing the threshold current for the induction of tonic seizures. " 03/01/2010 - "The present findings indicate that sarcosine did not lower the seizure threshold. " 03/01/2010 - "In the iv PTZ test, sarcosine did not exert a significant effect on the seizure threshold at any of the doses tested (100, 200, 400 and 800 mg/kg, ip). " 02/01/2008 - "Furthermore, pretreatment with sarcosine was effective in controlling pentylenetetrazol-induced seizures. " 03/01/2010 - "Therefore, we examined the effects of sarcosine on the seizure threshold in two different mouse seizure models: the timed intravenous (iv) pentylenetetrazole (PTZ) infusion test and the maximal electroshock seizure threshold test. "
4.	Neurobehavioral Manifestations 01/01/2014 - "After obtaining an informed consent, we started administration of 2 g of sarcosine per day to treat persistent negative and cognitive symptoms. " 02/01/2008 - "Full agonists of the glycine site, glycine and D-serine and a glycine transporter-1 inhibitor, sarcosine, added to antipsychotic drugs, have been shown to be effective in the treatment of negative symptoms and possibly cognitive symptoms without significantly affecting the positive symptoms of schizophrenia. " 01/01/2015 - "In this article, we describe a case of a 34-year-old woman with diagnosis of schizophrenia with persistent moderate negative and cognitive symptoms, a participant of the Polish Sarcosine Study (PULSAR) treated with olanzapine (25 mg per day) and venlafaxine (75 mg per day). "
5.	Neoplasms (Cancer) 02/01/2015 - "We found that PCA3, phi and sarcosine levels were significantly higher in patients with tumor volume (TV)≥0.5 ml, pathologic Gleason sum (GS)≥7 and pT3 disease (all p-values≤0.01). " 01/01/2015 - "Among cancer cases, nominal logistic regression was used for the association of sarcosine with Gleason grade. " 01/01/2015 - "For cancer cases, pre-diagnostic serum was utilized for sarcosine measurement. " 11/01/2012 - "We provide evidence that serum sarcosine has a higher predictive value than tPSA and %fPSA in patients with PSA < 4 ng/ml. Moreover, sarcosine levels were significantly different in low grade versus high grade cancers in this subset of patients, suggesting that this marker may be a further tool not only for diagnosing PCa in normal PSA and abnormal DRE/TRUS patients but also for selecting candidates for non-aggressive therapies and active surveillance." 11/01/2012 - "Moreover, in patients with a PSA < 4 ng/ml, the percentage of low/intermediate-grade cancers was positively associated with sarcosine levels (P = 0.005). "

Related Drugs and Biologics

1.	Glycine (Aminoacetic Acid)
2.	Sarcosine (Methylglycine)
3.	Proline (L-Proline)
4.	Serine (L-Serine)
5.	N-Methylaspartate (NMDA)
6.	Antipsychotic Agents (Antipsychotics)
7.	Risperidone (Risperdal Consta)
8.	Pentylenetetrazole (Metrazol)
9.	Uric Acid (Urate)
10.	Teniposide (VM 26)

Related Therapies and Procedures

1.	Analgesia
2.	Prostatectomy (Retropubic Prostatectomy)
3.	Ligation
4.	Castration
5.	Highly Active Antiretroviral Therapy (HAART)