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Mast-Cell Sarcoma

Subscribe to New Research on Mast-Cell Sarcoma

A unifocal malignant tumor that consists of atypical pathological MAST CELLS without systemic involvement. It causes local destructive growth in organs other than in skin or bone marrow.

Also Known As:

Malignant Mastocytoma; Malignant Mastocytomas; Mast Cell Sarcoma; Mast-Cell Sarcomas; Mastocytomas, Malignant; Sarcoma, Mast Cell; Sarcomas, Mast-Cell; Mastocytoma, Malignant; Sarcoma, Mast-Cell

Networked: 9 relevant articles (0 outcomes, 0 trials/studies)

Disease Context: Research Results

Neoplasms: 649836
- Neoplasms by Histologic Type: 1
  - Connective and Soft Tissue Neoplasms
    - Connective Tissue Neoplasms: 6
      - Mastocytosis: 639
        Mast-Cell Sarcoma: 9

Related Diseases

1.	Neoplasms (Cancer)
2.	Leukemia
3.	Acute Myeloid Leukemia (Acute Myelogenous Leukemia)
4.	Fever (Fevers)
5.	Ascites

Experts

1.	Akin, Cem: 2 articles (04/2013 - 08/2003)
2.	Ryan, Russell J H: 1 article (04/2013)
3.	Hornick, Jason L: 1 article (04/2013)
4.	Wills, Marcia: 1 article (04/2013)
5.	Selig, Martin K: 1 article (04/2013)
6.	Ferry, Judith A: 1 article (04/2013)
7.	Nielsen, G Petur: 1 article (04/2013)
8.	Castells, Mariana: 1 article (04/2013)
9.	Xu, Xia: 1 article (11/2011)
10.	Liu, Wei Ping: 1 article (11/2011)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Mast-Cell Sarcoma:

1.	imatinib (Gleevec)FDA Link 04/01/2013 - "Molecular testing of mast cell sarcoma has not thus far detected the imatinib-resistant KIT D816V mutation, suggesting that recognition of these cases may facilitate specific targeted therapy." 11/01/2011 - "Our results indicate that imatinib is of potential use in the treatment of mast cell sarcoma." 11/01/2011 - "Successful treatment of mast cell sarcoma of the uterus with imatinib." 11/01/2011 - "We report successful treatment of uterine mast cell sarcoma with imatinib in a 39-year-old woman who presented with abdominal distention and massive ascites. "
2.	Stem Cell FactorIBA 08/01/2003 - "Two novel stem cell factor (SCF) dependent human mast cell lines, designated LAD 1 and 2, were established from bone marrow aspirates from a patient with mast cell sarcoma/leukemia. " 08/01/2003 - "Characterization of novel stem cell factor responsive human mast cell lines LAD 1 and 2 established from a patient with mast cell sarcoma/leukemia; activation following aggregation of FcepsilonRI or FcgammaRI."
3.	RadiumIBA 03/01/1994 - "The following total tumors (benign plus malignant) occurred in control dogs but not in radium dogs: brain = 3, peritoneum = 1, and pituitary = 4. Malignant tumors other than leukemia appearing in control animals and not among radium dogs were brain = 2, lymph nodes = 1, adrenal = 3, uterus = 1, and pancreas = 5. Tumors that occurred in dogs given radium and not in controls were 3 mast cell sarcomas and 2 tumors of the thymus (1 malignant). "
4.	InterferonsIBA 02/01/2003 - "Despite interferon therapy, a mast-cell sarcoma of the sternum developed 1 year after symptom onset, followed 1 year later by acute myeloblastic leukemia, which was rapidly fatal."
5.	CortisoneIBA 11/01/1953 - "Preliminary observations on the use of cortisone in canine mast cell sarcoma."

Therapies and Procedures

1.	Radiotherapy 12/15/1988 - "A large infiltrating mast cell sarcoma in a dog, which had been refractory before surgical excision, was controlled 2 months after completion of a combined radiotherapy and hyperthermia regimen. " 12/15/1988 - "Use of hyperthermia and radiotherapy in treatment of a large mast cell sarcoma in a dog."
2.	Combination Drug Therapy (Combination Chemotherapy) 02/01/2001 - "Temporary response of localized intracranial mast cell sarcoma to combination chemotherapy." 02/01/2001 - "Systemic combination chemotherapy led to marked transient tumor regression in this proliferating mast cell sarcoma in an unusual intracranial location."
3.	Drug Therapy (Chemotherapy) 04/01/1989 - "Lymphoid leucaemia in a dog after chemotherapy for mast cell sarcomas."