HOME PRODUCTS SERVICES COMPANY CONTACT FAQ

Experimental Sarcoma

Subscribe to New Research on Experimental Sarcoma

Experimentally induced neoplasms of CONNECTIVE TISSUE in animals to provide a model for studying human SARCOMA.

Also Known As:

Sarcoma, Experimental; Experimental Sarcomas; Sarcomas, Experimental; Engelbreth-Holm-Swarm Sarcoma; Jensen Sarcoma; Sarcoma, Engelbreth Holm Swarm; Tumor, EHS; EHS Tumor; Sarcoma, Engelbreth-Holm-Swarm; Sarcoma, Jensen

Networked: 216 relevant articles (2 outcomes, 22 trials/studies)

Relationship Network

Disease Context: Research Results

Neoplasms: 649836
- Experimental Neoplasms: 47
  - Experimental Sarcoma: 216
- Neoplasms by Histologic Type: 1
  - Connective and Soft Tissue Neoplasms
    - Sarcoma: 14738
      - Experimental Sarcoma: 216
        Sarcoma 180: 772
        Yoshida Sarcoma: 421
        Avian Sarcoma: 335
        Sarcoma 37: 86

Related Diseases

1.	Neoplasm Metastasis (Metastasis)
2.	Body Weight (Weight, Body)
3.	Neoplasms (Cancer)
4.	Insulin Resistance
5.	Hyperglycemia

Experts

1.	Robertson, Graham R: 3 articles (09/2013 - 05/2011)
2.	Clarke, Stephen J: 3 articles (09/2013 - 05/2011)
3.	Hayashi, Yoshitaka: 3 articles (04/2004 - 03/2003)
4.	Sekiguchi, Kiyotoshi: 3 articles (04/2004 - 03/2003)
5.	Nagaoka, Masato: 2 articles (01/2015 - 01/2010)
6.	Duncan, Stephen A: 2 articles (01/2015 - 01/2010)
7.	Liddle, Christopher: 2 articles (09/2013 - 05/2011)
8.	Sharma, Rohini: 2 articles (09/2013 - 05/2011)
9.	Kacevska, Marina: 2 articles (09/2013 - 05/2011)
10.	Paulsson, Mats: 2 articles (09/2010 - 07/2004)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Experimental Sarcoma:

1.	Doxorubicin (Adriamycin)FDA LinkGeneric 09/01/1995 - "Isolated single-lung perfusion with doxorubicin hydrochloride was shown to be effective in clearing experimental sarcoma lung metastases in the rat. " 07/01/1997 - "Isolated lung perfusion with doxorubicin results in a durable response and prolongs survival in the treatment of experimental sarcoma pulmonary metastases."
2.	ChlorineIBA 05/01/2014 - "Photodynamic therapy of experimental sarcoma M-1 with boronated chlorine as a photosensitizer." 05/01/2014 - "Using rat model of experimental sarcoma M-1 we studied the efficacy of photodynamic therapy with boronated chlorine as a photosensitizer in doses of 1.25, 2.5, 5.0, and 10.0 mg/ kg body weight. "
3.	Laminin (Merosin)IBA 09/01/1996 - "In the present study, adhesion of mouse bone marrow-derived mast cells (BMMC) and long-term mast cell lines to Engelbreth-Holm-Swarm (EHS) tumor laminin, rat laminin, human merosin, and human placental laminin was compared. " 01/01/1993 - "Protein studies indicated that the M subunit is absent in laminin preparations from the EHS tumor whereas it is abundant in the laminin from placenta and in commercial merosin. " 07/01/2010 - "The CD spectra of recombinant laminin-121 were very similar to those of laminin-111 isolated from Engelbreth-Holm-Swarm tumor (EHS-laminin) but its T(m) value was smaller than EHS-laminin and recombinant lamnin-111 suggesting that the replacement of the β chain reduced the stability of the coiled-coil structure of laminin-121. " 10/01/1999 - "The ability of bovine corneal and conjunctival epithelial cells in primary culture to attach to laminin isolated from human placenta or from mouse EHS tumor was measured using a short-term colorimetric adhesion assay. " 07/01/1995 - "Western blot analysis revealed that laminin extracted from the tongue differs from EHS tumor laminin. "
4.	CollagenIBA 09/01/1994 - "In the postembedding method, antibody to EHS tumor collagen was also localized to both basal laminae. " 04/29/1987 - "It is likely that glycosylation and hydroxylation of collagen IV account for the major differences in molecular weight of mature alpha 1(IV) and alpha 2(IV) chains in the EHS tumor matrix." 04/29/1987 - "Pulse-chase studies of EHS tumor in organ culture as well as in vitro translation of EHS tumor RNA suggest that the precursor forms of alpha 1(IV) and alpha 2(IV) collagen chains are nearly identical in size, with apparent molecular weights of 170,000. " 06/01/1991 - "In ELISA-style receptor assays, the isolated alpha 1 beta 1 integrin bound to human and chick collagen IV and to mouse EHS tumor and chick heart laminin. " 08/01/1998 - "2. Among the extracellular matrix compounds used in this study, two (collagen I and fibronectin) allowed only a weak attachment of cortical neurons to the substratum, while the others (collagen IV, laminin, and basal lamina from Engelbreth-Holm-Swarm sarcoma) allowed both firm attachment and moderate to extensive neurite outgrowth from neuronal cell bodies. "
5.	Cyclophosphamide (Cytoxan)FDA LinkGeneric 06/01/1960 - "[Comparative histological cytophotometric and biochemical studies on the effect of endoxan on Jensen sarcoma in the rat]." 08/01/1978 - "Influence of cyclophosphamide on the antibody response evoked by an experimental sarcoma in rats." 01/01/1974 - "[Therapeutic experiments with spores of strain Clostridium butyricum and Cyclophosphamide in Jensen sarcoma, Walker carcinoma, and DS carcinosarcoma of the rat (author's transl)]." 01/01/1965 - "Survival experiments and cures after the administration of cyclophosphamide ester, triethyleneiminebenzoquinone and radiation separately and in various combinations with Yoshida sarcoma, carcinoma Walker and Jensen sarcoma in albino rats]." 01/01/1984 - "[Modification of selected leukocyte functions in albino rats caused by the transplantable Jensen sarcoma and by therapeutic trials of cyclophosphamide and vinblastine, Clostridium butyricum M55 and short-term hyperglycemia]."
6.	Collagen Type IV (Type IV Collagen)IBA 11/01/1996 - "It is known that the type IV collagen extracted from EHS tumor assembles under a physiological condition, but not in a gel form. " 10/01/1989 - "We herein report the cross-reactivity of a rabbit polyclonal antibody to EHS tumor-derived type IV collagen towards rat SP-A. " 08/01/1988 - "The macromolecular structural organization of the type IV collagen network in the extracellular matrix of the EHS tumor has been investigated using a stereoscopic freeze-dry Pt/C replication technique. " 08/01/1988 - "Type IV collagen lateral associations in the EHS tumor matrix. " 09/04/1986 - "Comparison of non-collagenous type IV collagen components in the human glomerulus and EHS tumor."
7.	matrigelIBA 10/01/2015 - "Matrigel and similar commercial products are extracts of the Engelbreth-Holm-Swarm sarcoma that provide a basement-membrane-like attachment substrate or gel that is used to grow cells on or in, respectively. " 05/01/2001 - "This unit describes methods for passaging and harvesting the basement membrane matrix-producing EHS tumor and for the subsequent isolation of a crude mixture of basement membrane components termed Matrigel, which promotes the differentiation of a variety of epithelial, endothelial, and neuronal cells. " 05/01/1993 - "Matrigel is a solubilized tissue basement membrane gel extracted from the mouse Engelbreth-Holm-Swarm sarcoma. " 06/01/1991 - "An extract of EHS tumor (matrigel) coated on culture chamber filters was used as an in vitro model of basement membranes. " 01/01/2010 - "To maintain pluripotency of human embryonic stem (huES) cells in feeder-free culture it has been necessary to provide a Matrigel substratum, which is a complex of poorly defined extracellular matrices and growth factors derived from mouse Engelbreth-Holm-Swarm sarcoma cells. "
8.	Fibronectins (Fibronectin)IBA 09/01/1994 - "It binds to Engelbreth-Holm-Swarm(EHS) tumor laminin and rat plasma fibronectin, but does not bind to human plasma fibronectin." 04/05/1992 - "CBP30 binds to murine Engelbreth-Holm-Swarm (EHS) tumor laminin and human amniotic fluid fibronectin but not human plasma fibronectin. " 03/01/1986 - "Laminin was isolated from the mouse EHS tumor and fibronectin from human plasma. " 01/01/1986 - "The extracellular matrix from endothelial cells mimics fibronectin and induces a flat phenotype whereas the reconstituted basement membrane gel from the EHS tumor mimics laminin and allows an elongated phenotype. " 08/01/1998 - "2. Among the extracellular matrix compounds used in this study, two (collagen I and fibronectin) allowed only a weak attachment of cortical neurons to the substratum, while the others (collagen IV, laminin, and basal lamina from Engelbreth-Holm-Swarm sarcoma) allowed both firm attachment and moderate to extensive neurite outgrowth from neuronal cell bodies. "
9.	Collagen Type I (Type I Collagen)IBA 12/15/2004 - "Moreover, they were induced to differentiate into hepatocytes and cholangiocytes by overlaying Engelbreth-Holm-Swarm sarcoma (EHS) gel and by embedding in type I collagen gel, respectively. " 11/01/1999 - "The induction was observed only in hepatocytes cultured on Engelbreth-Holm-Swarm sarcoma basement membrane gel (EHS-gel), not on type I collagen, which is usually used for monolayer culture of hepatocytes. " 08/01/1994 - "Freshly isolated hepatocytes were cultured on an EHS-gel prepared from EHS-tumor, poly-N-p-vinylbenzyl-D-lactonamide (PVLA), and type I collagen (TIC). " 11/01/1998 - "In this study, we show that hepatocyte LRP expression decreases rapidly at the mRNA, protein, and functional levels on collagen type I, but remains high on an Engelbreth-Holm-Swarm sarcoma matrix-preparation, Matrigel. " 09/01/1998 - "Four types of materials, type I collagen coat (Coat), acid-soluble type I collagen gel (Hardgel), pepsin-treated acid-soluble type I collagen gel (Softgel), and an extract of extracellular matrix of the murine Engelbreth-Holm-Swarm sarcoma (Matrigel), were used as matrices to culture rat hepatic parenchymal cells, and their morphological changes and adhesion were compared to the matrices by electron microscopic observations. "
10.	Messenger RNA (mRNA)IBA 09/01/1996 - "The results of the reverse transcription polymerase chain reaction method indicated that LL2-Lu3 cells contained mRNA for B1 and B2 chains, but not A chain corresponding to those of typical laminin derived from murine Engelbreth-Holm-Swarm sarcoma. " 11/01/1998 - "In this study, we show that hepatocyte LRP expression decreases rapidly at the mRNA, protein, and functional levels on collagen type I, but remains high on an Engelbreth-Holm-Swarm sarcoma matrix-preparation, Matrigel. " 05/01/1994 - "The 1.8-kb species of transcript was expressed in a constitutive manner, whereas the 3.8-kb mRNA was found to be regulated by angiotensin II. Laminin complexes secreted by cultured cells contained a approximately 300 kD heavy chain which did not immunoreact with immunoreagents raised against either the classical laminin complex secreted by EHS tumor cells or the merosin heavy chain. " 08/01/1987 - "We have obtained cDNA clones coding for the A, B1, and B2 chains of laminin by screening a cDNA library prepared from mouse EHS tumor poly(A)RNA in the lambda gt11 expression vector with polyclonal antibody against denatured laminin. " 03/15/1989 - "Since the cDNA clones have been isolated from a basement membrane tumor (EHS) cDNA library, we measured the vimentin mRNA production in EHS tumor cells in culture, and found that this mRNA is half as abundant as mRNA for type-IV mRNA."

Therapies and Procedures

1.	Photochemotherapy (Photodynamic Therapy) 05/01/2014 - "Photodynamic therapy of experimental sarcoma M-1 with boronated chlorine as a photosensitizer." 05/01/2014 - "Using rat model of experimental sarcoma M-1 we studied the efficacy of photodynamic therapy with boronated chlorine as a photosensitizer in doses of 1.25, 2.5, 5.0, and 10.0 mg/ kg body weight. "
2.	Hypophysectomy 06/17/1992 - "This study is the first to document the profound inhibitory effect of hypophysectomy on the metastatic behavior of an experimental sarcoma. "
3.	Adrenalectomy 08/15/1953 - "[Experimental studies on the effect of adrenalectomy on the growth of Jensen sarcoma in rat]."
4.	Transplantation (Transplant Recipients) 04/01/2004 - "EHS tumor arose spontaneously in an ST/Eh strain mouse and has been propagated by transplantation. " 01/01/1961 - "[Transplantation of experimental sarcoma of Citellus maximus]." 01/01/1986 - "Similar changes were found in animals with transplantation tumors (Walker carcinoma and Jensen sarcoma). " 01/01/1981 - "Rats were differently treated after transplantation of cells of Jensen sarcoma to test the influence of Doparkin (increase of the cAMP level), morbilli vaccine (interferon inductor) and local radio-therapy alone or in combination for a decrease of the rate of growing tumors. " 09/01/1986 - "The effect of transplantation of rat tumours Jensen sarcoma, sarcoma 45, sarcoma M-1, as well as of inoculation of rat normal connective tissue on the processes of biotransformation of antitumour preparations cyclophosphane (CP), thiophosphamide, prospidine and of model compound nitrosomorpholine (NM) was studied. "
5.	Radiotherapy 01/01/1989 - "[Cyto- and histomorphologic changes in the Jensen sarcoma exposed to cisplatin, radiotherapy and combination treatment]." 01/01/1987 - "[Histomorphologic changes in Jensen sarcoma following radiotherapy, titanocene dichloride treatment and combination therapy]." 06/01/1969 - "[Use of radiotherapy, sarcolysine and colchamine in the treatment of experimental sarcoma]."