Ewing's Sarcoma (Sarcoma, Ewing)

A malignant tumor of the bone which always arises in the medullary tissue, occurring more often in cylindrical bones. There are conspicuous foci of necrosis in association with irregular masses of small, regular, rounded or ovoid cells with very scanty cytoplasm. The tumor occurs usually before the age of 20, about twice as frequently in males as in females. (From Dorland, 27th ed; Stedman, 25th ed)
Also Known As:
Sarcoma, Ewing; Sarcoma, Ewing's; Ewing Tumor; Ewings Tumor; Sarcoma, Ewings; Tumor, Ewing's; Ewing's Tumor
Networked: 1407 relevant articles (73 outcomes, 145 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Neoplasms (Cancer)
2. Sarcoma (Soft Tissue Sarcoma)
3. Osteosarcoma (Osteogenic Sarcoma)
4. Rhabdomyosarcoma
5. Neoplasm Metastasis (Metastasis)


1. Kleinerman, Eugenie S: 20 articles (02/2014 - 05/2002)
2. Scotlandi, Katia: 20 articles (09/2012 - 03/2002)
3. Picci, Piero: 19 articles (09/2012 - 03/2002)
4. Zhou, Zhichao: 15 articles (02/2014 - 05/2002)
5. Kovar, Heinrich: 15 articles (08/2012 - 08/2002)
6. Lessnick, Stephen L: 14 articles (01/2013 - 05/2002)
7. Manara, Maria Cristina: 13 articles (09/2012 - 03/2002)
8. Serra, Massimo: 13 articles (04/2012 - 03/2002)
9. Notario, Vicente: 11 articles (09/2013 - 04/2002)
10. Ferrari, S: 11 articles (07/2011 - 01/2000)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Ewing's Sarcoma:
1. IfosfamideFDA LinkGeneric
2. Cyclophosphamide (Cytoxan)FDA LinkGeneric
3. Etoposide (VP 16)FDA LinkGeneric
4. Doxorubicin (Adriamycin)FDA LinkGeneric
5. Vincristine (Oncovin)FDA LinkGeneric
6. Dactinomycin (Ac-De)FDA LinkGeneric
7. AnthracyclinesIBA
8. Protons (Proton)IBA
9. Dihydrotachysterol (AT 10)IBA
01/01/2002 - "We report a 32-year-old women with a pelvic Ewing's sarcoma, who developed skeletal metastases within 20 months of diagnosis but following treatment remains disease-free at 10 years. "
04/01/2015 - "Patients with Ewing's sarcoma have decreased cause-specific survival at 10 years when metastatic at presentation, axial tumor location, tumor size>10cm, and patient age≥20 years."
02/01/1995 - "Important advances discussed over this period include: establishment of sarcoma teams in major oncology centers; staging systems for both soft tissue and osseous sarcomas; demonstration of genetic determinants in the development of, at least, some of the sarcomas; the revolutionary change in quality of diagnostic imaging by the introduction of CT and MRI; use of immunohistochemistry in diagnostic pathology; the drastic gains in survival of patients with osteogenic sarcoma, Ewing's sarcoma and rhabdomyosarcoma due to the efficacy of multi-drug and multi-cycle chemotherapy protocols; major advances in surgical techniques which have made limb salvage practical; cell lines derived from human sarcomas have been shown to have in vitro radiation sensitivity comparable to that of cell lines from epithelial tumors; the combination of conservative surgery and moderate doses of radiation yields local control and survival results equivalent to that of radical surgery with a much improved functional and cosmetic outcome; intra-operative electron beam radiation therapy improves the outcome of patients with retroperitoneal sarcomas when given after grossly complete resection combined with external beam radiation therapy (pre- or postoperatively); radiation is a highly effective alternative to extensive surgery for desmoid tumors; local control of giant cell tumors by modern radiation techniques is approximately 80% and the incidence of radiation induced tumors at 10 years is approximately 3%; to decrease the incidence of radiation induced sarcoma, resection has replaced radiation in the management of selected patients with primary Ewing's sarcoma when the response to chemotherapy has been excellent and the morbidity/functional decrement consequent upon the surgery judged reasonable; proton beam radiation therapy has been accepted as being superior to conventional external beam radiation therapy for chondrosarcoma and chordoma of the skull base; and attempts to utilize brachytherapy for sarcomas of the spine/sacrum appear to offer promise. "
10. Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA

Therapies and Procedures

1. Drug Therapy (Chemotherapy)
2. Radiotherapy
3. Adjuvant Chemotherapy
4. Heterologous Transplantation (Xenotransplantation)
5. Aftercare (After-Treatment)