Sarcoma 180

12/01/1995 - "Properties of water-insoluble mitomycin C-albumin conjugate as a sustained release drug delivery system in mice inoculated with Sarcoma 180."
08/04/1995 - "These mitomycin derivatives including 3a-c and 4a-c were evaluated for their anticellular activity against HeLa S3 cells and antitumor activity against Sarcoma 180 in mice. "
10/01/1987 - "Effect of gamma radiation alone or in combination with mitomycin C on endogenous nuclease activity of sarcoma 180 nuclei."
01/01/1982 - "Spleen lymphocytes collected from ICR mice which had been immunized with mitomycin C-treated sarcoma 180 (S180) cells one week earlier showed cytotoxic activity against viable S180 cells. "
06/10/1994 - "Most compounds were potent against HeLa S3, and some of them showed superior activity to that of mitomycin C (MMC) against P388 leukemia and sarcoma 180 in mice. "

08/01/2013 - "The in vivo antitumor activities of the conjugates against mice bearing sarcoma 180 tumor cell line were better than 5-FU. "
01/01/2001 - "To throw light on these questions, we investigated the effects of HBO and 5-fluorouracil (5-FU), individually and in combination, on Sarcoma 180 implants in mice. "
03/01/1984 - "Furthermore, combinations with BLM, CY, MMC or 5-FU, BLM, CY, MMC significantly inhibited the growth of intraperitoneally inoculated Meth A or Sarcoma 180, respectively. "
05/01/1971 - "[Transplantibility of sarcoma 180 and 298 cells after their preliminary incubation with 5-fluorouracil]."
01/01/1963 - "The growth-stimulating effect of TSPA and 5-FU on cells of sarcoma 180."

08/01/2010 - "Comparison of pharmacokinetics, intracellular localizations and sonodynamic efficacy of endogenous and exogenous protoporphyrin IX in sarcoma 180 cells."
08/01/2010 - "The aim of the present study was to investigate the differences in pharmacokinetics, sub-cellular localizations and sonodynamic efficacy between endogenous and exogenous protoporphyrin IX (endo-PpIX and exo-PpIX) in sarcoma 180 (S180) cells. "
04/01/2008 - "This study was to investigate whether the apoptosis in isolate sarcoma 180 (S180) cells could be enhanced by ultrasound in the presence of protoporphyrin IX (PPIX) and also to evaluate the underlying biologic mechanism. "
04/01/2008 - "The present study was initiated to investigate the potential biological mechanism of cell killing effect on isolate sarcoma 180 (S180) cells induced by ultrasound activating protoporphyrin IX (PPIX). "
01/01/2013 - "DNA damage and cell cycle arrest induced by protoporphyrin IX in sarcoma 180 cells."

01/01/2012 - "In the present study, the anticancer efficacy of dichloromethane extracts of Lycoris aurea (DELA), was evaluated both in vivo and in vitro using murine sarcoma 180 cells. "
06/01/2011 - "IC50 value of dichloromethane fraction was 94.2 μg/ml against sarcoma 180 cells lower than any other solvent fractions. "
06/01/2011 - "The objective of this study was to evaluate and compare the antitumor activity of different solvent fractions (ethanol, dichloromethane, ethyl acetate, butanol and water) of the Auricularia auricula-judae 70% ethanol extract on the P388D1 macrophage and sarcoma 180 cells. "

02/01/1978 - "Following a single course of therapy, essentially no toxicity was observed, and the antitumor effects were 2-fold (L1210 leukemia) and 4-fold (Sarcoma 180) greater than a single, maximally tolerated dose (24/kg s.c.) methotrexate alone. "
11/01/1981 - "Synthesis of poly-gamma-glutamyl metabolites of methotrexate was demonstrated in mouse small intestine, liver, and bone marrow and in L1210 leukemia, Sarcoma 180, and Ehrlich tumor cells after s.c. "
01/01/1983 - "Synthesis of poly-gamma-glutamyl metabolites of methotrexate was demonstrated in mouse small intestine, liver and bone marrow, and in L1210 leukemia, Sarcoma 180 and Ehrlich tumor cells after sc injections of [3H]methotrexate to tumor bearing mice. "
01/01/1984 - "These new analogs were found to be markedly superior to methotrexate against four of five ascites tumors (L1210 leukemia, Sarcoma 180, Ehrlich carcinoma and Tapper carcinosarcoma) and against four of five solid tumors (S180, Tapper carcinosarcoma, E0771 mammary adenocarcinoma, Lewis lung carcinoma, and T241 sarcoma). "
08/01/1993 - "The effects of vitamin A on methotrexate treatment of mice inoculated with L1210 leukaemia cells or sarcoma 180 cells were studied. "

01/01/1989 - "Repeated intraperitoneal and intratumor administration of polyhexamethylene guanidine (PMG) in 3 and 5 mg/kg doses to sarcoma 180 bearing mice caused a significant reduction in tumour mass accompanied by increased incidence of diploid and hypodiploid cells. "
07/01/1985 - "Previous studies showed that a cartilage-derived anti-tumor factor (CATF), which was extracted from bovine cartilage with 1 M guanidine hydrochloride, inhibited the growth of solid sarcoma 180, but not the growth of ascites tumors of sarcoma 180 [Suzuki, F. "

11/01/1984 - "The regressive activity of lentinan against the solid form of Sarcoma 180 was the most effective in DBA/2, SWM/Ms, or A/J mice and less effective in C3H/He or C57BL/6 mice. "
11/02/2009 - "The sulfated glucan fractions exhibited in vitro antiproliferative activities against sarcoma 180 (S-180) cells, and their inhibition ratios were lower than that of the triple-helix lentinan, but higher than that for the one with single random-coil lentinan chains."
06/01/1995 - "The strain difference in the intensity of skin reactions coincided with those observed in VDH responses and with lentinan-induced antitumor effects against Sarcoma 180. "
02/01/1988 - "When treatment with X-ray irradiation and lentinan was applied for mice bearing solid type sarcoma 180, additive effect was obtained by the combination of lentinan before or after X-ray irradiation."
03/15/1980 - "The effect of lentinan treatment was most variable in random-bred Swiss albino mice bearing sarcoma 180. "

09/01/1997 - "Drug-treated macrophages, when co-incubated with sarcoma 180 cells, establish cytoplasmic contact and transfer lysosomes into tumor cells causing tumor cell lysis. "
04/01/1989 - "When given intraperitoneally to mice, CO-N inhibited the proliferation of sarcoma 180 cells inoculated into the peritoneal cavity and exhibited a marked life-prolonging effect against ascitic tumors such as Ehrlich carcinoma and IMC carcinoma. "
03/01/1955 - "The partial mitotic inhibition caused by 6-mercaptopurine in tissue cultures of Crocker mouse sarcoma 180 and embryonic mouse skin is blocked by co-enzyme A. "
07/01/1991 - "New rhodium(I) complexes, belonging to the general structure [Rh(CO)2 (L)], where dithiocarbamate and xanthate derivatives, were synthesized and assayed as cytostatic and antitumour agents in vitro against KB cells and in vivo against P388 leukaemia, Ehrlich ascites carcinoma, Sarcoma 180 ascites and ADJ/PC6A solid tumour. "
05/30/1990 - "The activity of 5-fluorouracil against Sarcoma 180 (ascites) and Ehrlich (ascites) carcinoma was significantly enhanced by co-administration with (I). "

07/01/1952 - "Nucleic acid changes in sarcoma 180 following administration of aminopterin."
10/15/1988 - "N to C conversion at the N-5 position of aminopterin reduced its influx (inferred from the change in Ki) 3-fold, but the same modification increased influx of methotrexate 2-3-fold in Sarcoma 180 cells. "
04/01/1985 - "However, in Sarcoma 180 cells, only aminopterin polyglutamates reached a similar maximum percentage of accumulation, while lower relative polyglutamate levels were achieved with the other analogues. "
09/01/1949 - "Reversal of aminopterin-induced inhibition of sarcoma 180 by folic acid."
07/01/1978 - "In a smaller number of experiments comparing LD10 dosages (given q2d X 5) of aminopterin, methotrexate, and 10-deaza-aminopterin, aminopterin was the least effective and 10-deaza-aminopterin was the most effective against the L1210 leukemia, Sarcoma 180, and Ehrlich ascites tumors. "

07/01/1989 - "Amino acyl derivatives of hitachimycin have been synthesized and evaluated their activities including antibacterial, cytocidal against HeLa cells and in vivo antitumor against sarcoma 180. "
05/01/1989 - "Several carbonate derivatives of hitachimycin have been synthesized and evaluated their activities including antibacterial, cytocidal against HeLa cells and in vivo antitumor against Sarcoma 180. "
05/01/1988 - "Several acyl derivatives of hitachimycin have been synthesized and their activities, including antibacterial, cytocidal against HeLa cells and in vivo antitumor against sarcoma 180, evaluated. "
06/01/1982 - "Stubomycin showed antitumor activity against Sarcoma 180, IMC-carcinoma and Meth-A tumor. "
04/01/1983 - "Stubomycin, discovered by Dr. Umezawa, Kitasato Institute, is effective against Sarcoma 180, Ehrlich carcinoma, P388 leukemia, IMC carcinoma and Meth-A tumor in mice, and shows low acute toxicity. "

01/01/2009 - "The antitumor effect of LMPAB was examined using mouse sarcoma 180 (S180) xenograft models. "
09/01/2012 - "In vivo induction of apoptosis by fucoxanthin, a marine carotenoid, associated with down-regulating STAT3/EGFR signaling in sarcoma 180 (S180) xenografts-bearing mice."
07/01/2005 - "In mouse tumor xenograft models, intraperitoneal administrations of PA (10 mg/kg) daily or DOX (2 mg/kg) every other day for 9 days significantly inhibited the growth of sarcoma 180, whereas a combination of the two strongly inhibited tumor growth as compared with PA or DOX alone (p<0.01). "
02/01/2004 - "The inhibition activity of 8-CA (8-chloroadenosine, a new anti-tumor drug synthesized in our lab) in sarcoma 180, hepatocarcinoma 22, and human gastric carcinoma xenograft tumor has been confirmed. "
01/01/1991 - "The compound exhibited significant effects against various tumors such as P388 and L1210 leukemias; M5076 reticulum-cell sarcoma; colon 38 carcinoma; human xenografts MX-1, LX-1, GA-1, and Co-1; Lewis lung carcinoma; sarcoma 180; and Walker 256 carcinosarcoma and was especially effective against solid tumors. "

11/01/1976 - "Similar increases in enzyme activity were also observed in the livers of mice given injections of homogenates of Sarcoma 180 or Act. "
01/01/1986 - "Against solid sarcoma 180, triple injections of I-V caused reduction of mean tumor weight to 23-53% of control values, the dichloro complex I exhibiting most pronounced activity. "
02/01/1985 - "Single, intermittent, and successive injections of the antibiotic were almost equally effective against Ehrlich carcinoma, IMC carcinoma and sarcoma 180 tumor, but successive injections showed more efficacy than the other schedules against Meth A fibrosarcoma and Lewis lung carcinoma. "
01/01/1983 - "Synthesis of poly-gamma-glutamyl metabolites of methotrexate was demonstrated in mouse small intestine, liver and bone marrow, and in L1210 leukemia, Sarcoma 180 and Ehrlich tumor cells after sc injections of [3H]methotrexate to tumor bearing mice. "
01/01/1964 - "[PRELIMINARY DATA ON THE EFFECT OF ABSCESS PRODUCED BY INJECTIONS OF TURPENTINE AND DISTREPTASE ON SARCOMA (SARCOMA 180) IN MICE. "

01/01/1980 - "A dose of 1 mg/kg given 3 days before sarcoma 180 transplant produced complete protection (100% survival). "
01/01/1960 - "[On artificial active immunization to transplants of sarcoma-180]."
10/01/1989 - "The findings of in vitro-ex vivo tests (unidirectional mixed lymphocyte culture reaction and primary antibody production) and in vivo tests (delayed type hypersensitivity, protection against bacterial or fungal infection and against Sarcoma 180 or Lewis lung carcinoma transplants) were very encouraging and allowed to assume for the two substances a protective activity, presumably through the ability of activating phagocytic and NK cells."
05/01/1975 - "[Influence of the tumor process induced by 3-methylcholanthrene and benz(A)pyrene on the development of sarcoma 180 transplants]."

04/21/2010 - "And in vivo efficacy of combination chemotherapy was also evaluated using ICR mice bearing sarcoma 180 carcinoma tumors. "
05/01/1973 - "Combination chemotherapy of sarcoma 180 with methotrexate and bleomycin."
10/01/1977 - "Four neoplasms, Sarcoma T241, Adenocarcinoma E0771, Lewis lung carcinoma (LL), and Sarcoma 180 Japan (S180J), considered to have high deaminase and sufficient dCR-kinase activities, were tested in vivo for combination chemotherapy with cytosine arabinoside (ara-C) and the CR-deaminase inhibitor, tetrahydrouridine (THU). "

11/01/1987 - "Intravenous injection of the ET-18-OMe with sn-3 configuration retarded the subcutaneous growth of Sarcoma 180 cells effectively, while the growth inhibition by the sn-1 isomer was much less effective. "
05/01/1983 - "M-83 was also markedly effective against solid tumors of sarcoma 180, Meth 1, Meth A and Lewis lung carcinoma, by a single intravenous injection. "