Saponins

A type of glycoside widely distributed in plants. Each consists of a sapogenin as the aglycone moiety, and a sugar. The sapogenin may be a steroid or a triterpene and the sugar may be glucose, galactose, a pentose, or a methylpentose.

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Networked: 1400 relevant articles (102 outcomes, 217 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Kim, Dong-Hyun: 14 articles (04/2015 - 01/2006)
2.	Fuchs, Hendrik: 14 articles (02/2015 - 08/2005)
3.	Melzig, Matthias F: 14 articles (02/2015 - 08/2005)
4.	Weng, Alexander: 12 articles (02/2015 - 10/2009)
5.	Tang, Haifeng: 11 articles (04/2015 - 02/2008)
6.	Tang, Hai-Feng: 10 articles (05/2015 - 05/2005)
7.	Wang, Ying: 10 articles (03/2015 - 12/2007)
8.	Jeong, Hye Gwang: 10 articles (02/2015 - 02/2002)
9.	Kim, Yeong Shik: 9 articles (01/2015 - 11/2006)
10.	Thakur, Mayank: 9 articles (11/2014 - 03/2010)

Related Diseases

1.	Infection 01/01/2008 - "vannamei immersed in water containing saponin at 2mgL(-1) or less exhibited an immunomodulatory effect, as well as protection against V. alginolyticus infection." 11/01/2011 - "[Study on correlations between total saponins content in rhizome or mycorrhizal infection rate of Pairs polyphylla var. yunnanensis and soil factors]." 02/01/2005 - "The objective of this study was to determine whether a commercially available, saponin-adjuvanted, inactivated bovine respiratory syncytial virus (BRSV) vaccine would protect calves from experimental infection with virulent BRSV. " 06/01/2015 - "2 weeks after the last boost, mice were infected, and at 90 days post-infection, rEmP29-vaccinated mice exhibited a median parasite weight that was reduced by 75% and 59% when compared to NaCl- or saponin-treated control mice, respectively. " 01/01/2014 - "donovani infection in the saponin + LAg group, despite a concurrent increase in proinflammatory IFN-γ production. "
2.	Neoplasms (Cancer) 06/01/2008 - "The review also describes saponins in combination with conventional tumor treatment strategies, which result in improved therapeutic success. " 12/05/2012 - "Collectively, our study shows experimental evidence that TT has a preventive efficacy against UVB-induced carcinogenesis and the molecular knowledge on the mechanisms through which TT saponins regulate cell death suggests great potential for TT to be developed into a new medicine for cancer patients." 07/15/2014 - "Saponins have shown promise in cancer prevention and therapy; however, little is known about the detailed signaling pathways underlying their anticancer activities. " 02/01/2009 - "Saponins as tool for improved targeted tumor therapies." 10/01/2015 - "In the present study, it was demonstrated that WRC3, a novel saponin derivative, can inhibit B16 cancer cells by inducing apoptotic cell death with an IC50 value of 12.09 µM. "
3.	Visceral Leishmaniasis (Kala Azar) 01/08/2010 - "Leishmune, the first licensed vaccine for prophylaxis against canine visceral leishmaniasis (CVL) and is also immunotherapeutic when used with double saponin adjuvant concentration. " 01/30/2008 - "A vaccine against canine visceral leishmaniasis (CVL), comprising Leishmania braziliensis promastigote protein, sand fly gland extract (SGE) and saponin adjuvant, was evaluated in dog model, in order to analyse the immunogenicity of the candidate vaccine. " 11/01/2007 - "Cellular and humoral immune responses of dogs to a candidate vaccine, composed of Leishmania braziliensis promastigote protein plus saponin as adjuvant, have been investigated as a pre-requisite to understanding the mechanisms of immunogenicity against canine visceral leishmaniasis (CVL). " 08/14/2007 - "In order to assess the immunotherapeutic potential on canine visceral leishmaniasis of the Leishmune vaccine, formulated with an increased adjuvant concentration (1mg of saponin rather than 0.5mg), 24 mongrel dogs were infected with Leishmania (L.) chagasi. " 01/08/2007 - "Assessment of the monoterpene, glycidic and triterpene-moieties' contributions to the adjuvant function of the CP05 saponin of Calliandra pulcherrima Benth during vaccination against experimental visceral leishmaniasis."
4.	Carcinoma (Carcinomatosis) 01/01/2015 - "The present study examined antioxidant capacity and invasive ability in HeLa carcinoma cells exposed to brittle star crude saponins. " 01/01/2015 - "The present study aimed to analyze the impact of saponin extract from TT on cell processes in breast carcinoma cell lines. " 01/01/2012 - "In this study, we report the cytotoxic activity of the total saponins of Tupistra chinensis Baker (TST) against several carcinoma cell lines, including A549, MCF-7 and HeLa cells with the IC50 values of 4.11 μg/ml, 6.47 μg/ml and 7.78 μg/ml respectively. " 12/01/2011 - "The aim of this study was to investigate the effect of Paris saponin I (PS I) on human gastric carcinoma cell growth and apoptosis and to explore the potential mechanisms. " 08/01/2005 - "[Experimental study of saponins from Tribulus terrestris on renal carcinoma cell line]."
5.	Inflammation 07/01/2015 - "HE staining showed that pseadoanaphylactoid reaction induced by notoginseng total saponin preparation injection is related to inflammation. " 04/22/2015 - "Thus, saponins induced inflammation whether the diet contained other legume components or not. " 04/22/2015 - "Saponins caused dose-dependent increases in the severity of inflammation independent of the basal diet, with concomitant alterations in digestive functions and immunological marker expression. " 04/01/2015 - "The rhizome of Anemarrhena asphodeloides (AA, family Liliaceae), which contains furostanol and spirostanol saponins, is a typical herbal medicine that improves learning and memory in rats and inhibits inflammation. " 05/01/2014 - "These results suggest that quinoa saponins may be used as functional food components for prevention and treatment of inflammation. "

Related Drugs and Biologics

1.	Antigens
2.	Fluorometholone (FML)
3.	QS 21 (QS21)
4.	Flavonoids
5.	Ginsenosides
6.	Vaccines
7.	Immunoglobulin G (IgG)
8.	Saponins
9.	panaxatriol
10.	GPI0100

Related Therapies and Procedures

1.	Ligation
2.	Oral Administration
3.	Injections
4.	Chinese Traditional Medicine (Traditional Chinese Medicine)
5.	Heterologous Transplantation (Xenotransplantation)