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Salivary Gland Neoplasms (Salivary Gland Cancer)

Subscribe to New Research on Salivary Gland Neoplasms

Tumors or cancer of the SALIVARY GLANDS.

Also Known As:

Salivary Gland Cancer; Cancer of the Salivary Gland; Neoplasms, Salivary Gland; Cancer, Salivary Gland; Cancers, Salivary Gland; Gland Neoplasm, Salivary; Gland Neoplasms, Salivary; Neoplasm, Salivary Gland; Salivary Gland Cancers; Salivary Gland Neoplasm; Cancer of Salivary Gland

Networked: 180 relevant articles (5 outcomes, 32 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Salivary Gland Neoplasms (Salivary Gland Cancer)
2.	Neoplasms (Cancer)
3.	Adenocarcinoma
4.	Adenoid Cystic Carcinoma (Cylindroma)
5.	Carcinoma (Carcinomatosis)

Experts

1.	Hamakawa, Hiroyuki: 6 articles (02/2009 - 03/2002)
2.	Kawamata, H: 5 articles (09/2004 - 06/2000)
3.	Licitra, Lisa: 4 articles (06/2014 - 05/2004)
4.	Uchida, Daisuke: 4 articles (03/2014 - 03/2002)
5.	Nakashiro, Koh-Ichi: 4 articles (06/2008 - 03/2002)
6.	Shintani, Satoru: 4 articles (06/2008 - 03/2002)
7.	Kawamata, Hitoshi: 4 articles (03/2008 - 03/2002)
8.	Sato, Mitsunobu: 4 articles (10/2004 - 03/2002)
9.	Hino, S: 4 articles (03/2003 - 06/2000)
10.	Uchida, D: 4 articles (03/2003 - 06/2000)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Salivary Gland Neoplasms:

1.	Protein Isoforms (Isoforms)IBA 05/23/2008 - "Role of Akt isoforms in HGF-induced invasive growth of human salivary gland cancer cells." 07/01/2005 - "To determine the association between the expression of p63 gene isoforms (TA and DeltaN) and salivary gland tumorigenesis, we performed reverse transcription-polymerase chain reaction analysis of these markers in 71 benign and malignant salivary gland neoplasms. " 05/23/2008 - "Our findings suggest that all of the Akt isoforms are required for the HGF-stimulated invasive growth of human salivary gland cancer cells, and that targeting a single Akt isoform could be effective in treating salivary gland cancers." 07/01/2005 - "We conclude that (1) p63 isoforms are differentially expressed in most benign and malignant tumors and may play distinct biological roles in certain salivary gland neoplasms; (2) p63 immunostaining do not correlate with the isoforms expression; and (3) isoform-specific antibodies are required for better cellular localization and biological correlations."
2.	Sulindac (Copal)FDA LinkGeneric 06/01/2009 - "Inhibition of the oncogenic Stat3-survivin pathway in these cells can be achieved by selective targeting techniques or treatment with the NSAID sulindac and holds promise for the treatment of salivary gland cancer." 12/01/2014 - "Retracted: The oncogenic effects of constitutive Stat3 signaling in salivary gland cancer cells are mediated by survivin and modulated by the NSAID sulindac." 06/01/2009 - "The oncogenic effects of constitutive Stat3 signaling in salivary gland cancer cells are mediated by survivin and modulated by the NSAID sulindac."
3.	trastuzumab (Herceptin)FDA Link 02/01/2004 - "Our overall results suggest that trastuzumab will not have a major role in treatment of salivary gland cancers of intercalated duct origin. " 02/01/2015 - "It is recommended that further work involves a large series of HER2/neu positive salivary gland cancers (randomized control trial) treated with chemotherapy with and without Herceptin. " 01/01/2005 - "Herceptin plus chemotherapy in relapsed and/or metastatic salivary gland cancer." 02/01/2004 - "As part of a Phase II trial of trastuzumab for treatment of incurable salivary gland cancer, we screened 137 tumors for HER2 expression. " 04/01/2003 - "Palliative chemotherapy in patients with salivary gland neoplasms and preliminary reports of 2 recent phase II studies with trastuzumab and gemcitabine."
4.	HormonesIBA 05/01/2011 - "The use of the hormone treatment in salivary gland cancers is controversial. " 10/01/2012 - "This paper reviewed exhaustively the studies investigating the role of systemic therapies (chemotherapy, targeted therapy, hormone therapy) in salivary gland cancers." 01/01/2012 - "This paper reviewed exhaustively the studies investigating the role of systemic therapies (chemotherapy, targeted therapy, hormone therapy) in salivary gland cancers."
5.	gefitinib (Iressa)FDA Link 05/01/2015 - "Phase II study of gefitinib in patients with advanced salivary gland cancers." 05/01/2015 - "We did not observe significant clinical activity of gefitinib in advanced salivary gland cancer. " 05/01/2015 - "The purpose of this study was to determine the antitumor activity of the epidermal growth factor receptor (EGFR) inhibitor gefitinib in patients with recurrent/metastatic salivary gland cancer. " 09/01/2007 - "ErbB1 and ErbB2 are also frequently overexpressed in salivary gland cancers and this has provided the rationale for clinical trials with trastuzumab, cetuximab, gefitinib, lapatinib. "
6.	gemcitabine FDA Link 01/15/2010 - "A phase 2 study of platinum and gemcitabine in patients with advanced salivary gland cancer: a trial of the NCIC Clinical Trials Group." 04/01/2003 - "Palliative chemotherapy in patients with salivary gland neoplasms and preliminary reports of 2 recent phase II studies with trastuzumab and gemcitabine."
7.	Messenger RNA (mRNA)IBA 08/01/2003 - "FHIT mRNA splicing does not appear to be involved in the genesis of salivary gland neoplasms. " 10/01/2013 - "HBD-2 mRNA and protein expressions are significantly increased in salivary gland benign tumor tissues and inflammation tissues compared with those in normal salivary gland tissues, but are significantly decreased in salivary gland cancer. " 10/01/2013 - "RT-PCR results showed that HBD-2 mRNA expression in salivary gland benign tumors, salivary gland cancer, and inflammation tissues was 6.468-, 0.334-, and 10.563-fold higher than that in normal tissues, respectively (P < 0.05). " 02/01/2004 - "The aim of this study was to analyse the mRNA expression of mdm2 in salivary gland neoplasms and to correlate it to immunoexpression of p53 and p21 proteins. " 03/01/2013 - "The absolute mRNA content of paraffin embedded samples of salivary gland cancer was determined by quantitative reverse transcription-polymerase chain reaction (qRT-PCR) using specific primers for NFkB1, GADD45A and JNK1. "
8.	ParaffinIBA 03/01/2013 - "The absolute mRNA content of paraffin embedded samples of salivary gland cancer was determined by quantitative reverse transcription-polymerase chain reaction (qRT-PCR) using specific primers for NFkB1, GADD45A and JNK1. " 09/01/2012 - "Detection of HPV types 16 & 18 was done on 34 formalin-fixed, paraffin-embedded archival material of different salivary gland neoplasms using Digene HPV types 16 & 18 probe using in situ hybridization technique. " 01/01/1989 - "Archival paraffin sections from normal salivary gland tissue and salivary gland neoplasms were stained by immunoperoxidase technique with a well characterized cytokeratin antibody (PKK1). " 05/01/2003 - "Formalin-fixed paraffin-embedded sections of 49 salivary gland neoplasms (17 monomorphic adenomas, 17 PLGAs, and 15 ACCs) accessioned between 1989 and 2002 were retrieved from the files of the Department of Pathology, Long Island Jewish Medical Center, and were stained with an anti-c-kit polyclonal antibody. " 10/01/2013 - "Formalin-fixed, paraffin-embedded tissue samples of different salivary gland neoplasms were processed for antibodies to ER-α and PR using the specifications of the manufacturer. "
9.	DNA (Deoxyribonucleic Acid)IBA 09/01/2011 - "Impact of WWOX alterations on p73, ΔNp73, p53, cell proliferation and DNA ploidy in salivary gland neoplasms." 05/01/2009 - "Abnormal DNA content is a common finding in salivary gland cancers. " 08/01/1997 - "Chromosomal and DNA ploidy characterization of salivary gland neoplasms by combined FISH and flow cytometry." 04/01/2014 - "We tested the hypothesis that aneuploid salivary gland tumours lose immunoexpression of STAG2 compared with diploid tumours using image cytometry to determine DNA ploidy and immunohistochemistry to assess STAG2 protein expression in 30 malignant salivary gland neoplasms. " 08/01/1997 - "Concurrent DNA ploidy by flow cytometry and interphase FISH analysis of chromosomes 6 through 12, 17, 18, X, and Y were prospectively performed on 22 salivary gland neoplasms (four benign and 18 malignant) to investigate the diagnostic and biological implications of their alterations in these neoplasms. "
10.	vesnarinoneIBA 10/21/2002 - "We previously demonstrated that a differentiation inducing drug, vesnarinone induced the growth arrest and p21(waf1) gene expression in a human salivary gland cancer cell line, TYS. " 10/21/2002 - "Vesnarinone, a differentiation inducing drug, directly activates p21(waf1) gene promoter via Sp1 sites in a human salivary gland cancer cell line." 01/01/1998 - "We undertook the present study to clarify the molecular mechanism of the effect of a new anti-cancer drug, vesnarinone, on a human salivary gland cancer cell line, TYS. " 01/01/1998 - "Induction of TSC-22 by treatment with a new anti-cancer drug, vesnarinone, in a human salivary gland cancer cell." 03/01/2003 - "Vesnarinone significantly suppressed the growth of TYS (salivary gland cancer cells), PC3 (prostate cancer cells), and A431 (squamous cell cancer cells). "

Therapies and Procedures

1.	Drug Therapy (Chemotherapy) 09/01/1986 - "Because of the scarcity of such lesions, little is known about the efficacy of chemotherapy for advanced salivary gland cancers. " 03/01/1982 - "This study reveals which drugs seem to be effective and provides some rational basis for future chemotherapy trials for salivary gland cancers." 03/01/1982 - "A total of 85 cases of salivary gland cancers treated with chemotherapy were felt to be evaluable for this study. " 03/01/1982 - "In an effort to arrive at a rational basis for recommending specific drug regimens for specific histologic types of salivary gland cancers, a two-part study was undertaken to determine which chemotherapy drugs seem to be effective or ineffective. " 02/01/2014 - "[Retrospective analysis of clinical and pathological factors that influence patient survival in salivary gland cancer - could chemotherapy improve survival ?]."
2.	Radiotherapy 09/01/2003 - "Neuron radiotherapy is an effective treatment for patients with salivary gland neoplasms who have gross residual disease and achieves excellent local-regional control in patients without evidence of gross disease." 09/01/2003 - "To evaluate the efficacy of fast neutron radiotherapy for the treatment of salivary gland neoplasms. " 03/01/2011 - "This study was designed to identify the factors associated with the outcome after standard treatment with surgery and postoperative radiotherapy (RT) for locally advanced salivary gland cancers. " 08/01/2014 - "A rationale for chemoradiation (vs radiotherapy) in salivary gland cancers? " 03/01/2014 - "From 1990 to 2009, 27 patients with unresectable salivary gland cancer underwent definitive photon radiotherapy at our institution. "
3.	Oral Surgery (Maxillofacial Surgery) 03/01/1998 - "We believe that day-case oral and maxillofacial surgery is safe and effective, but that caution should be exercised when operating on benign submandibular salivary gland neoplasms under general anaesthesia." 08/15/2004 - "This study was aimed at establishing the prevalence, sex, age, and site distribution of salivary gland neoplasms as seen in the Department of Oral Surgery Mulago Hospital Uganda. "
4.	Neck Dissection (Radical Neck Dissection) 01/01/2004 - "In conclusion neck dissection should be considered as an integral part of the surgical concept in major salivary gland cancer patients." 07/01/2003 - "Neck dissections should be considered as an integral part of the surgical approach in patients with major salivary gland cancer, especially if no postoperative radiation therapy is planned." 08/01/2002 - "A retrospective study of 40 patients who underwent surgery, including neck dissection, for major salivary gland cancer between 1975 and 1997 was performed. " 05/01/2015 - "All 87 patients with high-grade salivary gland cancers underwent curative surgery combined with neck dissection and most of them received postoperative radiotherapy or chemoradiotherapy. " 01/01/2004 - "b) To ascertain the incidence of clinically apparent and occult lymph node metastases in patients with major salivary gland cancers we analyzed 160 consecutive patients that underwent parotidectomy and neck dissection. "
5.	Molecular Targeted Therapy 09/01/2007 - "Recent advances in the treatment of salivary gland cancers: emphasis on molecular targeted therapy." 06/01/2008 - "Basic evidence of molecular targeted therapy for oral cancer and salivary gland cancer."