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Sulfasalazine (Azulfidine)

Subscribe to New Research on Sulfasalazine

A drug that is used in the management of inflammatory bowel diseases. Its activity is generally considered to lie in its metabolic breakdown product, 5-aminosalicylic acid (see MESALAMINE) released in the colon. (From Martindale, The Extra Pharmacopoeia, 30th ed, p907)

Also Known As:

Azulfidine; Pleon; Salazopyrin; Sulphasalazine; Ucine; Salicylazosulfapyridine; Alphapharm Brand of Sulfasalazine; Ashbourne Brand of Sulfasalazine; Asulfidine; Azulfadine; Azulfidine EN; Colo-Pleon; FNA Brand of Sulfasalazine; Henning Berlin Brand of Sulfasalazine; Heyl Brand of Sulfasalazine; Pfizer Brand of Sulfasalazine; Pyralin EN; Ratiopharm Brand of Sulfasalazine; Salazosulfapyridine; Sanofi Synthelabo Brand of Sulfasalazine; Sulfasalazin medac; Sulfasalazin-Heyl; Sulfasalazine FNA; Ulcol; medac Brand of Sulfasalazine; ratio-Sulfasalazine; Colo Pleon; EN, Azulfidine; Sulfasalazin Heyl; Sulfasalazine Pfizer Brand; ratio Sulfasalazine; Benzoic acid, 2-hydroxy-5-((4-((2-pyridinylamino)sulfonyl)phenyl)azo)-

Networked: 2038 relevant articles (286 outcomes, 305 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Boers, Maarten: 9 articles (06/2015 - 02/2002)
2.	Braun, J: 9 articles (12/2013 - 01/2002)
3.	Sieper, J: 9 articles (04/2011 - 01/2002)
4.	van der Heijde, Désirée: 7 articles (01/2014 - 01/2003)
5.	O'Dell, James R: 7 articles (08/2013 - 05/2002)
6.	Sontheimer, Harald: 7 articles (08/2012 - 08/2005)
7.	Gout, Peter W: 7 articles (03/2010 - 01/2003)
8.	Smolen, J S: 7 articles (07/2009 - 06/2000)
9.	Lems, Willem F: 6 articles (06/2015 - 07/2004)
10.	Dhaneshwar, Suneela S: 6 articles (04/2014 - 04/2007)

Related Diseases

1.	Ulcerative Colitis 12/01/1985 - "Sulfasalazine is of proven efficacy as maintenance therapy in ulcerative colitis. " 09/01/1990 - "Since the development of sulfasalazine about a half century ago, the prognosis for patients with ulcerative colitis has improved significantly. " 04/01/1985 - "In the case of sulphasalazine, adult slow acetylators require a lower daily dose of the drug than fast acetylators in order to maintain ulcerative colitis in remission without significant side effects. " 08/01/1985 - "The disparity of the therapeutic efficacy and effects on NK activity of sulphasalazine and its derivatives in vitro may suggest that NK activity is not a major pathogenic mechanism in ulcerative colitis. " 05/01/1983 - "Sulfasalazine is of major benefit in preventing relapses in patients with ulcerative colitis in remission. "
2.	Rheumatoid Arthritis 03/01/1985 - "However, its safety profile is far superior, and very long-term treatment with sulphasalazine is a safe option for treatment of rheumatoid arthritis." 09/01/2014 - "Sulfasalazine (SSZ) and tofacitinib are effective for treating rheumatoid arthritis, however, their effects on chondrocytes have not been fully understood. " 08/01/1993 - "We conclude that sulphasalazine is equally effective in rheumatoid arthritis in the elderly as in the young. " 01/01/1993 - "Sulfasalazine is an efficient treatment for rheumatoid arthritis (RA), but its mode of action is not known. " 01/01/1992 - "The influence of acetylator status on the therapeutic efficacy and the toxicity of sulphasalazine (SASP) was assessed in 106 patients with rheumatoid arthritis (RA). "
3.	Crohn Disease (Crohn's Disease) 04/01/1986 - "Crohn's disease was associated with a significant reduction in family size independent of steroid or sulphasalazine treatment." 02/01/1985 - "It is also suggested that Salazopyrin is more effective in cases with short duration of symptoms, i.e., in cases previously untreated for Crohn's disease. " 05/01/1991 - "Sulfasalazine has not been uniformly effective in preventing relapse in Crohn's disease, although many clinicians continue its use in patients who respond initially. " 12/01/1983 - "In treatment of Crohn's disease, sulfasalazine has been shown to be effective when disease involves the colon or the colon and small intestine. " 01/01/2010 - "In conclusion, sulfasalazine shows modest efficacy for the treatment of active Crohn's disease. "
4.	Colitis 01/01/2010 - "Sulfasalazine was more likely to induce remission (RR 1.38; 95% CI 1.02 to 1.87; n = 263) compared to placebo with benefit confined mainly to patients with colitis. " 11/01/1987 - "In haemorrhagic recto-colitis, these various preparations have, in the whole, a similar effectiveness to that of Salazopyrin in controlling moderately active forms or in keeping the patient in remission. " 08/01/1984 - "A second trial with sulfasalazine was, again, followed by a rapid and sever relapse of the colitis. " 11/06/2015 - "Amelioration of colitis by either of the drug candidates was comparable to that achieved by orally administered sulfasalazine or 5-ASA. " 06/01/2015 - "Rats from the non-colitis and non-treated colitis groups were administered vehicle (saline, 5 ml/kg) orally and another group received sulfasalazine (50mg/kg/day). "
5.	Inflammatory Bowel Diseases (Inflammatory Bowel Disease) 08/01/1992 - "Sulfasalazine is an important therapeutic agent in the management of chronic inflammatory bowel disease (CIBD). " 08/01/2001 - "5-ASA, sulfasalazine and 6-MP, while beneficial in inflammatory bowel disease, do not directly control MAdCAM-1, and are beneficial through inhibition of other inflammatory processes." 10/01/1991 - "Sulphasalazine and 5-ASA, at concentrations of 10(-5)-10(-3) M significantly inhibit lipid peroxidation, suggesting an antioxidant action that may explain the efficacy of these drugs in treating inflammatory bowel disease. " 12/01/1981 - "On the contrary, sulphasalazine resulted in a reduced response which was significantly greater for the group with inflammatory bowel disease than the control group (P less than 0.05). " 01/01/2001 - "Since its synthesis in the 1930s and subsequent introduction, sulfasalazine has been an effective treatment for inflammatory bowel disease. "

Related Drugs and Biologics

1.	Mesalamine (Mesalazine)
2.	Methotrexate (Mexate)
3.	Adrenal Cortex Hormones (Corticosteroids)
4.	olsalazine (Dipentum)
5.	Hydroxychloroquine (Plaquenil)
6.	Prednisone (Sone)
7.	Azathioprine (Imuran)
8.	Sulfapyridine
9.	Steroids
10.	Sulfasalazine (Azulfidine)

Related Therapies and Procedures

1.	Enema (Enemas)
2.	Drug Therapy (Chemotherapy)
3.	Remission Induction
4.	Oral Administration
5.	Aftercare (After-Treatment)