Safrole (Safrol)

A member of the BENZODIOXOLES that is a constituent of several VOLATILE OILS, notably SASSAFRAS oil. It is a precursor in the synthesis of the insecticide PIPERONYL BUTOXIDE and the drug N-methyl-3,4-methylenedioxyamphetamine (MDMA).

Also Known As:

Networked: 67 relevant articles (1 outcomes, 9 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Rietjens, Ivonne M C M: 4 articles (10/2017 - 08/2012)
2.	Vervoort, Jacques: 3 articles (10/2017 - 04/2014)
3.	Jan, Chung-Ren: 3 articles (10/2015 - 07/2005)
4.	Chung, Jing-Gung: 3 articles (11/2013 - 05/2012)
5.	Yang, Jai-Sing: 3 articles (11/2013 - 05/2012)
6.	Yu, Chun-Shu: 3 articles (11/2013 - 05/2012)
7.	Chi, Chin-Wen: 3 articles (02/2009 - 04/2004)
8.	Chung, Yu-Ting: 3 articles (02/2009 - 04/2004)
9.	Liu, Tsung-Yun: 3 articles (02/2009 - 04/2004)
10.	Alajlouni, Abdalmajeed M: 2 articles (10/2017 - 03/2016)

Related Diseases

1.	Neoplasms (Cancer) 05/29/2021 - "The safrole oil may be applied for the prevention and treatment of oxidative stress, diabetes, different microbial species and cancer, and these activities could be improved by nano-carriers." 02/01/2011 - "In vivo studies also showed that safrole reduced the size and volume of an HSC-3 solid tumor on a xenograft athymic nu/nu mouse model. " 05/29/2021 - "Then the antimicrobial activity of the safrole oil and safrole nanoemulgel were performed on different microbial species, and cytotoxicity was determined against Hep3B cancer cell lines using the MTS assay. " 01/01/2014 - "These results demonstrated that safrole is potent anti-hepatoma agent and the underlying mechanism may be attributed to suppress tumor cell growth by inducing cell apoptosis. " 11/01/2013 - "We have previously reported that safrole induced apoptosis in human oral cancer cells in vitro and inhibited the human oral tumor xenograft growth in vivo. "
2.	Hepatocellular Carcinoma (Hepatoma) 01/01/2014 - "The aim of this study was to study the anti-hepatoma effect of safrole and elucidate its molecular mechanism, the human hepatoma BEL-7402 cells were incubated with various concentrations (40, 80, 160, 320 and 640 μg/ml) of safrole and the cell proliferation and apoptosis were evaluated. " 11/01/2018 - "However, safrole has been shown to be associated with the development of hepatocellular carcinoma. " 09/18/2012 - "Safrole, a naturally occurring product derived from spices and herbs, has been shown to be associated with the development of hepatocellular carcinoma in rodents. " 02/08/2000 - "Safrole in betel quid may be a risk factor for hepatocellular carcinoma: case report." 08/01/1981 - "Hepatocellular carcinomas (HPC) occurred in livers of mice exposed to safrole for 52-75 weeks. "
3.	Mouth Neoplasms (Oral Cancer) 07/01/2005 - "The present study examined whether safrole could alter Ca2+ handling and growth in human oral cancer OC2 cells. " 02/01/2011 - "Safrole induces apoptosis in human oral cancer HSC-3 cells." 04/11/2004 - "It has been recently demonstrated that safrole (4-allyl-1,2-methylenedioxybenzene)-DNA adducts are present in oral cancer tissue from patients who have chewed areca quid (AQ) containing high concentration of safrole. " 11/01/2013 - "We have previously reported that safrole induced apoptosis in human oral cancer cells in vitro and inhibited the human oral tumor xenograft growth in vivo. " 07/01/2005 - "Independent [Ca2+]i increases and cell proliferation induced by the carcinogen safrole in human oral cancer cells."
4.	Necrosis 03/01/1998 - "Conversely, safrole, tannic acid, and urethane yet hepatotoxicants did not show inflammatory reaction or necrosis under the condition of the present study, and hence their mode of action by which they induce proliferative response was not obvious. " 10/01/1996 - "Pretreatment with isosafrole, safrole, dihydrosafrole, and benzodioxole at dosages as low as 10 mg/kg significantly prevented the increase in plasma transaminase levels and histochemical changes associated with CCl4-induced liver necrosis, whereas piperonyl butoxide (PBO), eugenol, isoeugenol, sesamol, and curcumin did not prevent CCl4 hepatotoxicity even at 200 mg/kg. However, isosafrole was only partly hepatoprotective if administered 10 min after the toxicant. "
5.	Stomach Neoplasms (Stomach Cancer) 10/31/2015 - "These studies suggest that in SCM1 human gastric cancer cells, safrole induced [Ca²⁺](i) rises by inducing PLC-dependent Ca²⁺ release from the endoplasmic reticulum and Ca²⁺ influx via non-store-operated Ca²⁺ entry pathways. " 10/31/2015 - "The effect of safrole on cytosolic free Ca²⁺ concentrations ([Ca²⁺](i)) and viability in SCM1 human gastric cancer cells was explored. " 10/31/2015 - "The Mechanism of Safrole-Induced [Ca²⁺]i Rises and Non-Ca²⁺-Triggered Cell Death in SCM1 Human Gastric Cancer Cells."

Related Drugs and Biologics

1.	apiole
2.	Urethane (Ethyl Carbamate)
3.	Tannic Acid
4.	Biomarkers (Surrogate Marker)
5.	antineoplaston A10 (A 10)
6.	safrole oxide (SAFO)
7.	Carcinogens
8.	DNA Adducts
9.	DNA (Deoxyribonucleic Acid)
10.	estragole (methyl chavicol)

Related Therapies and Procedures

1.	Injections
2.	Oral Administration