Safflower Oil

An oily liquid extracted from the seeds of the safflower, Carthamus tinctorius. It is used as a dietary supplement in the management of HYPERCHOLESTEROLEMIA. It is used also in cooking, as a salad oil, and as a vehicle for medicines, paints, varnishes, etc. (Dorland, 28th ed & Random House Unabridged Dictionary, 2d ed)

Also Known As:

Oil, Safflower; Oils, Safflower; Safflower Oils; Safflower oil

Networked: 230 relevant articles (11 outcomes, 32 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Ezaki, Osamu: 4 articles (02/2012 - 12/2007)
2.	Belury, Martha A: 4 articles (08/2011 - 01/2003)
3.	Yamazaki, Tomomi: 3 articles (02/2012 - 12/2007)
4.	Akbari, Abolfazl: 2 articles (01/2022 - 07/2021)
5.	Mohamadian, Alireza: 2 articles (01/2022 - 07/2021)
6.	Nimrouzi, Majid: 2 articles (01/2022 - 07/2021)
7.	Ruyvaran, Maede: 2 articles (01/2022 - 07/2021)
8.	Halade, Ganesh V: 2 articles (01/2022 - 01/2019)
9.	Kain, Vasundhara: 2 articles (01/2022 - 01/2019)
10.	Connelly, Philip W: 2 articles (01/2018 - 07/2014)

Related Diseases

1.	Insulin Resistance 11/01/2009 - "Safflower oil increased hepatic beta-oxidation, was beneficial in terms of circulating TG-rich VLDL particles, but led to reduced hepatic insulin sensitivity. " 03/01/2010 - "When fed with a high-fat safflower oil diet for 3 wk, wild-type mice develop hepatic insulin resistance, whereas mice lacking glycerol-3-phosphate acyltransferase-1 retain insulin sensitivity. " 01/10/2022 - "Safflower oil without lifestyle modification improved abdominal obesity, blood pressure, and insulin resistance in patients with MetS." 11/01/2009 - "The aim of this study was to compare the effects of cocoa butter and safflower oil on hepatic transcript profiles, lipid metabolism and insulin sensitivity in healthy rats. " 03/01/2010 - "We examined early changes in the development of insulin resistance via liver and plasma metabolome analyses that compared wild-type and glycerol-3-phosphate acyltransferase-deficient mice fed with either a low-fat or the safflower oil diet for 3 wk. We reasoned that diet-induced changes in metabolites that occurred only in the wild-type mice would reflect those metabolites that were specifically related to hepatic insulin resistance. "
2.	Stroke (Strokes) 06/01/1992 - "Perilla oil has been found to be beneficial for the suppression of carcinogenesis, allergic hyperreactivity, thrombotic tendency, apoplexy, hypertension, and aging in animals, as compared with soybean oil and safflower oil. " 12/01/1998 - "For 15.6 months, SHRSP (stroke-prone spontaneously hypertensive strain) rats were fed a diet supplemented with lard, safflower oil, perilla oil or fish oil/soybean oil, the peroxidizability of which increases in this order. " 01/03/2000 - "Dietary docosahexaenoic acid ameliorates, but rapeseed oil and safflower oil accelerate renal injury in stroke-prone spontaneously hypertensive rats as compared with soybean oil, which is associated with expression for renal transforming growth factor-beta, fibronectin and renin." 01/03/2000 - "We have noted that n-3 fatty acid-rich oils, such as fish oil, perilla oil and flaxseed oil as well as ethyl docosahexaenoate (DHA) prolonged the survival time of stroke-prone spontaneously hypertensive rats (SHRSP) rats by approximately 10% as compared with linoleate (n-6)-rich safflower oil. "
3.	Neoplasms (Cancer) 11/01/1987 - "The growth rate of tumors from mice fed the high safflower oil diet was significantly greater than the growth rate of tumors for mice fed all other diets including the one which contained the minimal EFA. " 01/01/1997 - "Tumor weights were highest in animals fed 10% safflower oil and treated with saline, intermediate in animals fed oil containing DHA and 5% safflower oil and treated with saline, and lowest in araC-treated animals from all diets. " 08/01/1989 - "Marine oil tumors were smaller than safflower oil tumors (P less than 0.005 by analysis of variance; P less than 0.01 by Scheffe test). " 08/01/1989 - "At each time period animals fed safflower oil had larger tumors than those fed marine oil. " 12/01/1987 - "High fat diets (20%, w/w) that contained either 1, 2, 4, 8, or 12% 18:2 by weight, were prepared by using mixtures of coconut and safflower oil and fed to female BALB/c mice that were subsequently inoculated with 10(4) 4526 tumor cells s.c., either at the lateral abdominal wall (LAW) or in the mammary fat pad (MFP). "
4.	Obesity 03/15/2010 - "The aim of this study was to investigate the prevention of diet-induced obesity by a high safflower oil diet and adipocytic gene expression in mice. " 03/01/2008 - "Remarkably, safflower oil did not induce obesity in female UCP2 knockout mice, an unexpected phenotype for which we presently have no explanation. " 10/01/2020 - "This study investigated the potential protective effects of perilla, olive, and safflower oils on high-fat diet-induced obesity and colon inflammation. " 03/01/2008 - "UCP2 knockout and wild-type mice fed fish oil had lower rates of obesity than mice fed safflower oil. " 03/01/2008 - "UCP2 transgenic and wild-type mice fed a high-fat diet (safflower oil or lard) developed obesity to a similar degree. "
5.	Carcinogenesis 04/15/1997 - "Lack of promotion of colon carcinogenesis by high-oleic safflower oil." 01/01/1990 - "Dietary olive and safflower oils in promotion of DMBA-induced mammary tumorigenesis in rats." 07/10/2001 - "Site-dependent modulating effects of conjugated fatty acids from safflower oil in a rat two-stage carcinogenesis model in female Sprague-Dawley rats." 07/10/2001 - "Modifying effects of dietary administration of conjugated fatty acids from safflower oil (CFA-S), rich in conjugated linoleic acid, on major organs were examined in the post-initiation stage of a two-stage carcinogenesis model in female rats. " 03/01/2000 - "Rats were examined for the effect of dietary level of fat (beef tallow or safflower oil) on colonic activity of inducible nitric oxide synthase (iNOS) which has been suggested to be associated with colon carcinogenesis. "

Related Drugs and Biologics

1.	Soybean Oil
2.	Fish Oils
3.	Linoleic Acid (Linoleate)
4.	Oleic Acid (Oleate)
5.	Conjugated Linoleic Acids
6.	perilla seed oil
7.	Docosahexaenoic Acids
8.	Paclitaxel (Taxol)
9.	Emulsions
10.	Rapeseed Oil

Related Therapies and Procedures

1.	Fat-Restricted Diet (Diet, Fat Restricted)
2.	Therapeutics
3.	Transplantation
4.	Injections
5.	Caloric Restriction