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Rutin (Rutoside)

A flavonol glycoside found in many plants, including BUCKWHEAT; TOBACCO; FORSYTHIA; HYDRANGEA; VIOLA, etc. It has been used therapeutically to decrease capillary fragility.

Also Known As:

Rutoside; 3-Rhamnosyl-Glucosyl Quercetin; Quercetin-3-Rutinoside; Quercetin 3 Rutinoside; Quercetin, 3-Rhamnosyl-Glucosyl; 4H-1-Benzopyran-4-one, 3-((6-O-(6-deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranosyl)oxy)-2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-

Networked: 436 relevant articles (37 outcomes, 93 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 60
- Pyrans: 5
  - Benzopyrans: 11
    - Chromones: 27
      - Flavonoids: 2256
        Flavonols: 176
        Rutin: 436
        Phlogenzym: 14
        Wobenzym: 13
        Hydroxyethylrutoside: 10
        melilot: 6
        sandoven: 6
        rutoside drug combination ascorbic acid: 3
        Ercevit P: 2
        rutin sulfate: 2
        theo-esberiven: 2
        aescorin: 1
        antigrippen: 1
        Ercevit fort: 1
        rutin-N-mustard: 1
        theophylline-rutozide: 1
        trihydroxyethylrutin: 1
        2-hydroxyethylorutin
        4(G)-alpha-glucopyranosyl-rutin
        Fleboplex
        nirurin
        Psorival
        rutacil
        rutin decasulfonate sodium
        Vasoforte
        Venescin
- 2-Ring Heterocyclic Compounds
  - Benzopyrans: 11
    - Chromones: 27
      - Flavonoids: 2256
        Flavonols: 176
        Rutin: 436
        Phlogenzym: 14
        Wobenzym: 13
        Hydroxyethylrutoside: 10
        melilot: 6
        sandoven: 6
        rutoside drug combination ascorbic acid: 3
        Ercevit P: 2
        rutin sulfate: 2
        theo-esberiven: 2
        aescorin: 1
        antigrippen: 1
        Ercevit fort: 1
        rutin-N-mustard: 1
        theophylline-rutozide: 1
        trihydroxyethylrutin: 1
        2-hydroxyethylorutin
        4(G)-alpha-glucopyranosyl-rutin
        Fleboplex
        nirurin
        Psorival
        rutacil
        rutin decasulfonate sodium
        Vasoforte
        Venescin

Experts

1.	Nassiri-Asl, Marjan: 6 articles (09/2014 - 05/2008)
2.	Flaumenhaft, Robert: 4 articles (09/2015 - 06/2012)
3.	Wang, Wei: 4 articles (07/2015 - 09/2002)
4.	Khan, Rahmat Ali: 4 articles (11/2012 - 03/2010)
5.	Sahreen, Sumaira: 4 articles (11/2012 - 03/2010)
6.	Wolffram, S: 3 articles (01/2016 - 09/2012)
7.	Furie, Bruce: 3 articles (09/2015 - 06/2012)
8.	Abbasi, Esmail: 3 articles (01/2014 - 05/2010)
9.	Hu, Qing-Hua: 3 articles (01/2013 - 10/2009)
10.	Kong, Ling-Dong: 3 articles (01/2013 - 10/2009)

Related Diseases

1.	Inflammation 09/01/2012 - "Barrier protective effects of rutin in LPS-induced inflammation in vitro and in vivo." 09/01/2011 - "Efficacy of rutin against the nephrotoxicity was evaluated in terms of biochemical estimation of antioxidant enzyme activities, histopathological changes and expression levels of molecular markers of inflammation and apoptosis. " 04/25/2015 - "Therefore, our study revealed that rutin may be a promising modulator in attenuating CP induced oxidative stress, inflammation and hepatotoxicity via targeting NFκB and MAPK pathway." 11/01/2014 - "The results of the study revealed that rutin can reduce inflammation in pancreas probably by influencing the down regulation of ASC-NLRP3 which might result in the reduced activation of caspase-1 and controlled cytokine production." 10/01/2014 - "The present study was aimed to investigate the effects of rutin on UVB-induced inflammation in mouse skin in vivo. "
2.	Body Weight (Weight, Body) 09/01/2015 - "Supplementation with rutin reduced body weight and adipose tissue mass, despite equivalent energy intake (p < 0.05). " 01/01/2015 - "Separate groups of neonatal mice (C57BL/6) were administered with rutin at 25 or 50 mg/kg body weight (b.wt) from post natal day 2 (P1) to P21. " 11/01/2014 - "In addition, groups 2 and 4 rats received daily 100 mg/kg body weight of rutin from third week. " 09/01/2014 - "In addition, rats also received 100 mg rutin/kg body weight orally from 31st day till the experimental period. " 01/01/2014 - "Rutin (100 and 200 mg/kg) could prevent decrease of body weight in rats. "
3.	Colitis 12/01/2014 - "Treatment with rutin improved colitis at the dose of 57mg/kg/day, while no effect was noted with 28.5mg/kg/day. " 12/01/2014 - "Our aim was to study the antiinflamatory effect of rutin in the CD4+ CD62L+ T cell transfer model of colitis, one of the closest to the human disease. " 01/17/2012 - "Preparation of coated pellets intended for rutin colon delivery, their evaluation in vitro and in vivo in experimental colitis in rats was the purpose of this study. " 12/01/2014 - "Rutin has intestinal antiinflammatory effects in the CD4+ CD62L+ T cell transfer model of colitis." 01/17/2012 - "After colitis induction and development, the rats were treated with pellets and rutin solution administered orally, solution also rectally. "
4.	Venous Insufficiency 01/01/1981 - "A double-blind trial of O-(beta-hydroxyethyl)-rutoside in patients with chronic venous insufficiency." 04/01/2001 - "The aim of this comparative clinical study was to evaluate the efficacy of the association of alphatocopherol, rutin, melilotus officinalis, and centella asiatica with oral administration in patients with chronic venous insufficiency. " 01/01/1987 - "Venous insufficiency of the lower limbs in oral contraceptive users was treated with Venoruton 1000 (o-(beta-hydroxyethyl)-rutoside) at a high dose of 3 g/day in a double-blind, placebo controlled trial. " 04/01/2001 - "[Effectiveness of the combination of alpha tocopherol, rutin, melilotus, and centella asiatica in the treatment of patients with chronic venous insufficiency]." 01/01/2015 - "The first one compared a phlebotonic (rutoside) with placebo for the reduction in symptoms of varicose veins; the second study evaluated the efficacy of troxerutin in comparison to placebo among 30 pregnant women in their second trimester with symptomatic vulvar varicosities and venous insufficiency in their lower extremities. "
5.	Ischemia 07/01/2013 - "The present study was to examine the protective effects of rutin on gastric mucosal damage induced by gastric ischemia-reperfusion (I/R) in rats. " 04/15/2014 - "Rutin treatment starting 1h after injury attenuated BBB disruption during photothrombotic focal ischemia, which was partly, at least, achieved through inhibitory effects on MMP-9 expression and activity. " 07/01/2013 - "Rutin (50, 100, 200 mg/kg) was administered intragastrically for five consecutive days before ischemia. " 07/01/2013 - "Protective effect of rutin against acute gastric mucosal lesions induced by ischemia-reperfusion." 03/29/2013 - "Plasma availability of rutin was detected from 2h to at least 8h after ischemia. "

Related Drugs and Biologics

1.	Quercetin
2.	Curcumin
3.	Flavonoids
4.	Glucose (Dextrose)
5.	Hesperidin
6.	Reactive Oxygen Species (Oxygen Radicals)
7.	Cytokines
8.	troxerutin
9.	isoquercitrin
10.	tert-Butylhydroperoxide

Related Therapies and Procedures

1.	Oral Administration
2.	Aftercare (After-Treatment)
3.	Radiotherapy
4.	Intravenous Injections
5.	Drug Therapy (Chemotherapy)