Rutin (Rutoside)

A flavonol glycoside found in many plants, including BUCKWHEAT; TOBACCO; FORSYTHIA; HYDRANGEA; VIOLA, etc. It has been used therapeutically to decrease capillary fragility.

Also Known As:

Rutoside; 3-Rhamnosyl-Glucosyl Quercetin; Quercetin-3-Rutinoside; Quercetin 3 Rutinoside; Quercetin, 3-Rhamnosyl-Glucosyl; 4H-1-Benzopyran-4-one, 3-((6-O-(6-deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranosyl)oxy)-2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-

Networked: 1021 relevant articles (139 outcomes, 271 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrans: 130
    - Benzopyrans: 195
      - Chromones: 159
        Flavonoids: 9773
        Flavonols: 321
        Rutin: 1021
        Wobenzym: 16
        Phlogenzym: 15
        Hydroxyethylrutoside: 11
        rutoside drug combination esculoside dihydroergotoxine mesylate: 7
        volatile oil drug combination rutin resin coumarin: 6
        rutoside drug combination ascorbic acid: 4
        theo-esberiven: 3
        rutin sulfate: 2
        allantoin - escin - esculoside - hamamelis - methol - vitamin B1 - vitamin E: 1
        antigrippen: 1
        digoxigenin-3-O-rutin: 1
        Ercevit fort: 1
        monoglucosyl-rutin: 1
        Rutin Forte: 1
        rutin-N-mustard: 1
        theophylline-rutozide: 1
        2-hydroxyethylorutin
        4'-methyl-7-mono-O-(beta-hydroxyethyl)rutoside
        4(G)-alpha-glucopyranosyl-rutin
        7-mono-O-(beta-hydroxyethyl)rutoside
        alpha-oligoglucosyl rutin
        Fleboplex
        nirurin
        Psorival
        rutacil
        rutin decasulfonate sodium
        Vasoforte
        Venescin
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Benzopyrans: 195
      - Chromones: 159
        Flavonoids: 9773
        Flavonols: 321
        Rutin: 1021
        Wobenzym: 16
        Phlogenzym: 15
        Hydroxyethylrutoside: 11
        rutoside drug combination esculoside dihydroergotoxine mesylate: 7
        volatile oil drug combination rutin resin coumarin: 6
        rutoside drug combination ascorbic acid: 4
        theo-esberiven: 3
        rutin sulfate: 2
        allantoin - escin - esculoside - hamamelis - methol - vitamin B1 - vitamin E: 1
        antigrippen: 1
        digoxigenin-3-O-rutin: 1
        Ercevit fort: 1
        monoglucosyl-rutin: 1
        Rutin Forte: 1
        rutin-N-mustard: 1
        theophylline-rutozide: 1
        2-hydroxyethylorutin
        4'-methyl-7-mono-O-(beta-hydroxyethyl)rutoside
        4(G)-alpha-glucopyranosyl-rutin
        7-mono-O-(beta-hydroxyethyl)rutoside
        alpha-oligoglucosyl rutin
        Fleboplex
        nirurin
        Psorival
        rutacil
        rutin decasulfonate sodium
        Vasoforte
        Venescin

Experts

1.	Kandemir, Fatih Mehmet: 6 articles (07/2022 - 04/2015)
2.	Flaumenhaft, Robert: 6 articles (04/2022 - 06/2012)
3.	Nassiri-Asl, Marjan: 6 articles (03/2020 - 05/2008)
4.	Verma, Savita: 5 articles (02/2022 - 01/2017)
5.	Khan, Fahad: 5 articles (10/2021 - 01/2020)
6.	Pandey, Pratibha: 5 articles (10/2021 - 01/2020)
7.	Ren, Liqun: 5 articles (07/2021 - 11/2013)
8.	Kurt, Nezahat: 5 articles (01/2020 - 01/2018)
9.	Zhang, Yang: 4 articles (06/2022 - 01/2017)
10.	Caglayan, Cuneyt: 4 articles (11/2021 - 07/2019)

Related Diseases

1.	Inflammation (Inflammations) 03/01/2016 - "The aim of this study was to evaluate the protective effects of rutin against B(a)P-induced genotoxicity, oxidative stress, apoptosis and inflammation in Swiss albino mice. " 09/01/2012 - "Barrier protective effects of rutin in LPS-induced inflammation in vitro and in vivo." 01/01/2022 - "Rutin ameliorates inflammation and improves metabolic function: A comprehensive analysis of scientific literature." 08/01/2019 - "These findings clearly demonstrate that rutin ameliorates CFZ-induced oxidative stress and inflammation in nephrotoxicity via the NOS-mediated NF-κB signaling pathway." 10/27/2023 - "Previous studies have indicated that rutin can alleviate the injury of tissues and cells by inhibiting oxidative stress and ameliorating inflammation. "
2.	Neoplasms (Cancer) 11/01/2023 - "The anti-cancer activity of the rutin-loaded nanoliposomes was found to be concentration-dependent and significantly improved compared to free rutin. " 09/12/2021 - "Hence, we hypothesized that rutin could exhibit strong inhibitory efficacy against Jab1 and, thereby, induce significant growth arrest in SiHa cancer cells in a dose-dependent manner. " 01/01/2021 - "Over the recent few years rutin has gained wider attention in exhibiting inhibitory potential against several oncotargets for inducing apoptotic and antiproliferative activity in several human cancer cells. " 11/01/2023 - "PEGylated nanoliposomes with rutin (1.8 mg/ml) showed the highest encapsulation efficiency and drug loading ability, along with improved selectivity against cancer cells. " 07/20/2023 - "Our study provides a proof of concept for rutin as an emerging natural senomorphic agent, and presents an effective therapeutic avenue for alleviating age-related pathologies including cancer."
3.	Body Weight (Weight, Body) 03/30/2023 - "Dietary rutin significantly reversed HS-induced decrease in body weight, average daily feed intake, average daily gain, and feed efficiency. " 11/01/2022 - "Group 2, 3, 4 and 5 were orally administered with LCT (7.6 mg/kg body weight), rutin (200 mg/kg body weight) LCT and rutin (at the same doses as in Group 2 and Group 3), and LCT and a mixture of rutin with β-CD (400 mg/kg body weight), respectively. " 01/01/2022 - "Transition Hu sheep (2-3 years old with 62.90 ± 2.80 kg) were randomly divided into three groups, the control group was fed a diet without rutin, while rutin (50 and 100 mg/kg body weight/day) was administered to the two treatment groups (-28 day to +28 day relative to parturition). " 01/01/2021 - "Cu only treatment significantly decreased body weight gain, while rutin cotreatment reversed this decrease. " 01/01/2020 - "Groups IV to VII were treated with AM, DP but co-administered with 100, 200 mg rutin/kg body weight while groups VIII and IX received rutin (100 and 200 mg/kg body weight). "
4.	Colitis 08/30/2023 - "W-ZnRT was superior to rutin alone in chronic colitis (n = 9), although they were equally effective in acute colitis (n = 7). " 12/01/2014 - "Treatment with rutin improved colitis at the dose of 57mg/kg/day, while no effect was noted with 28.5mg/kg/day. " 12/01/2014 - "Our aim was to study the antiinflamatory effect of rutin in the CD4+ CD62L+ T cell transfer model of colitis, one of the closest to the human disease. " 01/17/2012 - "Preparation of coated pellets intended for rutin colon delivery, their evaluation in vitro and in vivo in experimental colitis in rats was the purpose of this study. " 11/01/2023 - "Moreover, a novel mechanism was elucidated by which rutin, the primary active component of MDGP, alleviates DSS-induced colitis. "
5.	Fibrosis (Cirrhosis) 06/01/2016 - "Rutin ameliorates kidney interstitial fibrosis in rats with obstructive nephropathy." 11/25/2023 - "The molecular docking analyses in this study predict that rutin occludes the active site of TβRI and inhibits SMAD-mediated fibrotic signaling pathways in lung fibrosis. " 07/01/2020 - "In conclusion, rutin can be proposed to be a potential therapeutic agent for the management of lung fibrosis." 01/01/2015 - "Rutin ameliorates renal fibrosis and proteinuria in 5/6-nephrectomized rats by anti-oxidation and inhibiting activation of TGFβ1-smad signaling." 05/01/2022 - "Quercetin-3-Rutinoside alleviates radiation-induced lung inflammation and fibrosis via regulation of NF-κB/TGF-β1 signaling."

Related Drugs and Biologics

1.	Quercetin
2.	Flavonoids
3.	Antioxidants
4.	Hesperidin
5.	Enzymes
6.	Curcumin
7.	Glucose (Dextrose)
8.	Cytokines
9.	Catechin (Z 7300)
10.	Resveratrol

Related Therapies and Procedures

1.	Therapeutics
2.	Oral Administration
3.	Aftercare (After-Treatment)
4.	Drug Therapy (Chemotherapy)
5.	Intraperitoneal Injections