Ruthenium

A hard, brittle, grayish-white rare earth metal with an atomic symbol Ru, atomic number 44, and atomic weight 101.07. It is used as a catalyst and hardener for PLATINUM and PALLADIUM.

Networked: 479 relevant articles (13 outcomes, 60 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Dyson, Paul J: 22 articles (12/2015 - 06/2005)
2.	Sava, Gianni: 21 articles (02/2015 - 07/2002)
3.	Sava, G: 17 articles (10/2015 - 04/2000)
4.	Keppler, Bernhard K: 16 articles (08/2015 - 06/2005)
5.	Chen, Tianfeng: 15 articles (07/2015 - 02/2010)
6.	Bergamo, A: 13 articles (10/2015 - 04/2000)
7.	Liu, Jie: 12 articles (10/2015 - 02/2010)
8.	Jakupec, Michael A: 12 articles (08/2015 - 08/2005)
9.	Bergamo, Alberta: 12 articles (02/2015 - 11/2002)
10.	Chao, Hui: 11 articles (10/2015 - 06/2013)

Related Diseases

1.	Neoplasms (Cancer) 01/14/2015 - "The very promising results of Na-trans-[RuCl4(1H-indazole)2] (NKP-1339) in clinical studies have fuelled renewed interest in the research and development of ruthenium(III) coordination compounds for cancer therapy. " 08/01/2015 - "The motivation to use ruthenium complexes in cancer treatment has led our research group to synthesize complexes with this metal and test them against several types of tumor cells, yielding promising results. " 06/01/2015 - "Taken together, the results of this study provide a strategy for the design of ruthenium-based radiosensitizers for use in cancer therapy." 08/01/2014 - "This study supports the potential use of some of these ruthenium complexes as adjuvants of glycolytic inhibitors in the treatment of aggressive cancers. " 07/23/2014 - "Studies have shown that ruthenium complexes have relatively strong anticancer activity, cell uptake of drugs have a crucial impact on the pharmacological activity, using autofluorescence of ruthenium complexes could effectively track cancer cells and drug distribution, transport accurately in real time. "
2.	Colorectal Neoplasms (Colorectal Cancer) 05/01/1989 - "Efficacy of new ruthenium complexes against chemically induced autochthonous colorectal carcinoma in rats." 02/01/2005 - "Colorectal tumor cell lines were used to analyze uptake of the ruthenium(III) complexes into the cells and the mechanism as well as the efficacy of their cytotoxic effects. " 02/01/2005 - "Heterocyclic complexes of ruthenium(III) induce apoptosis in colorectal carcinoma cells." 01/01/1992 - "Antineoplastic activity of three ruthenium derivatives against chemically induced colorectal carcinoma in rats." 08/26/2005 - "The heterocyclic ruthenium(III) complex KP1019 (FFC14A) causes DNA damage and oxidative stress in colorectal tumor cells."
3.	Neoplasm Metastasis (Metastasis) 01/01/2015 - "Herein, we reported that, RuPOP, a ruthenium polypyridyl complex with potent antitumor activity, was able to effectively inhibit growth and metastasis of MDA-MB-231 cells and synergistically enhance TRAIL-induced apoptosis. " 02/01/2004 - "Reduction of in vivo lung metastases by dinuclear ruthenium complexes is coupled to inhibition of in vitro tumour invasion." 11/01/2000 - "Data on ruthenium organ retention confirm lack of brain penetration and a relatively high lung concentration which might account for the remarkable effect on lung metastases." 05/01/1998 - "Pharmacological control of lung metastases of solid tumours by a novel ruthenium complex." 10/01/2014 - "The data of 22 patients with 23 eyes of choroidal metastasis undergoing ruthenium 106 radioactive applicator brachytherapy were retrospectively analyzed from the Eye Center of People Hospital of Peking University from Feb. "
4.	Carcinoma (Carcinomatosis) 12/01/2015 - "All triazenido-ruthenium complexes were highly cytotoxic against human cervical carcinoma HeLa cells with IC50 below 6μM, as determined by a spectrophotometric MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-tetrazolium bromide) method. " 06/01/2012 - "Induction of cell cycle arrest and apoptosis by ruthenium complex cis-(dichloro)tetramineruthenium(III) chloride in human lung carcinoma cells A549." 04/01/1992 - "We conclude from these data that two of six newly synthesized ruthenium complexes possess antiproliferative activity against a panel of human colon carcinoma cell lines. " 08/01/1963 - "CARCINOMA OF THE LUNG IN RATS EXPOSED TO THE BETA-RADIATION OF INTRABRONCHIAL RUTHENIUM PELLETS. " 12/05/2012 - "The in vivo study consisted in selecting the optimal arene ruthenium porphyrin photosensitizer by using an original experimental design approach on mice bearing an ectopic human oral carcinoma xenograft. "
5.	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 11/05/2012 - "Ruthenium(II/III)-based compounds with encouraging antiproliferative activity against non-small-cell lung cancer." 02/14/2006 - "Anti-tumour activity in non-small cell lung cancer models and toxicity profiles for novel ruthenium(II) based organo-metallic compounds." 12/02/2015 - "In vitro screening demonstrated that the as-prepared ruthenium complexes are anti-proliferating towards a series of cancer cell lines, in particular the non-small-cell lung cancer cell line A549. " 05/07/2013 - "A cytotoxicity assay of both ruthenium(III) compounds against two human cell lines (A549 - non-small cell lung carcinoma and T47D - breast carcinoma) was performed. " 02/01/2015 - "This phase I/II study determined the maximal tolerable dose, dose limiting toxicities, antitumor activity, the pharmacokinetics and pharmacodynamics of ruthenium compound NAMI-A in combination with gemcitabine in Non-Small Cell Lung Cancer patients after first line treatment. "

Related Drugs and Biologics

1.	imidazolium- bis(imidazole)dimethylsulfoxideimidazotetrachlororuthenate(III) (NAMI-A)
2.	DNA (Deoxyribonucleic Acid)
3.	Carrier Proteins (Binding Protein)
4.	gemcitabine
5.	Ibuprofen (Motrin)
6.	Transferrin (beta 2 Transferrin)
7.	Liposomes (Liposome)
8.	ferrocene
9.	Naphthoquinones
10.	apotransferrin

Related Therapies and Procedures

1.	Radiotherapy
2.	Brachytherapy
3.	Induced Hyperthermia (Thermotherapy)
4.	Drug Therapy (Chemotherapy)
5.	Photochemotherapy (Photodynamic Therapy)