Rodent Diseases

Diseases of rodents of the order RODENTIA. This term includes diseases of Sciuridae (squirrels), Geomyidae (gophers), Heteromyidae (pouched mice), Castoridae (beavers), Cricetidae (rats and mice), Muridae (Old World rats and mice), Erethizontidae (porcupines), and Caviidae (guinea pigs).

Also Known As:

Networked: 14 relevant articles (0 outcomes, 1 trials/studies)

Disease Context: Research Results

Related Diseases

1.	Retinal Degeneration
2.	Reperfusion Injury
3.	Pulmonary Fibrosis (Hamman Rich Syndrome)
4.	Parkinson Disease (Parkinson's Disease)
5.	Neoplasms (Cancer)

Experts

1.	Bernstein, Steven L: 1 article (05/2015)
2.	Miller, Neil R: 1 article (05/2015)
3.	Seganish, Jennifer: 1 article (01/2015)
4.	Rzasa, Robert M: 1 article (01/2015)
5.	Hao, Xiaolin: 1 article (01/2015)
6.	Hungate, Randall: 1 article (01/2015)
7.	McGee, Lawrence R: 1 article (01/2015)
8.	Yu, Gang: 1 article (01/2015)
9.	Medina, Julio C: 1 article (01/2015)
10.	Mohn, Deanna: 1 article (01/2015)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Rodent Diseases:

1.	Methylnitrosourea (N-Methyl-N-nitrosourea)IBA 01/01/2013 - "To study such diseases, rodent models of N-methyl-N-nitrosourea (MNU)-induced retinal degeneration are widely used. "
2.	Lactic AcidFDA LinkGeneric 10/01/1987 - "TNF/cachectin also increases plasma lactate, a change seen in both the human and rodent diseases. "
3.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 10/01/1987 - "TNF/cachectin also increases plasma lactate, a change seen in both the human and rodent diseases. "
4.	Sucrose (Saccharose)IBA 01/01/2005 - "As a prerequisite to investigating modifications to Complex I using a rodent disease model for PD, we developed two independent rapid and mild isolation procedures based on sucrose gradient fractionation and immunoprecipitation to isolate Complex I from mouse brain and a cultured rat mesencephalic dopaminergic neuronal cell line. "
5.	Gonadal Steroid Hormones (Sex Hormones)IBA 01/01/2009 - "Here, clinical and experimental data are reviewed with respect to the effects of sex hormones or gender in the pathology or therapy of MS or its rodent disease models. "
6.	Proteins (Proteins, Gene)IBA 11/21/2013 - "Described below is ABE/SILAM, a proteomic strategy that couples acyl-biotinyl exchange (ABE) purification of palmitoyl-proteins to whole animal stable isotope labeling (SILAM) to provide an accurate tracking of palmitoylation change within rodent disease models. "
7.	Protein Kinases (Protein Kinase)IBA 01/08/2015 - "This medicinal chemistry effort led to the identification of 1 (AMG319), a compound with an IC50 of 16 nM in a human whole blood assay (HWB), excellent selectivity over a large panel of protein kinases, and a high level of in vivo efficacy as measured by two rodent disease models of inflammation. "
8.	NADP (NADPH)IBA 01/01/2014 - "An inhibitor of NADPH oxidase-4 attenuates established pulmonary fibrosis in a rodent disease model."
9.	Metformin (Glucophage)FDA LinkGeneric 05/01/2010 - "Metformin administration in rodent disease models has been shown to delay cancer incidence and progression, reduce cardiovascular disease and extend life span. "
10.	Leucine (L-Leucine)FDA Link 10/21/2011 - "Leucine-rich repeat kinase-2 (LRRK2) mutations are the most important cause of familial Parkinson's disease, and non-selective inhibitors are protective in rodent disease models. "

Therapies and Procedures

1.	Homologous Transplantation (Allograft) 08/01/2003 - "Administration of CO, biliverdin, bilirubin or iron-binding compounds is protective in rodent disease models of ischemia-reperfusion injury, allograft and xenograft survival, intimal hyperplasia following balloon injury or as seen in chronic graft rejection and others. "
2.	Heterologous Transplantation (Xenotransplantation) 08/01/2003 - "Administration of CO, biliverdin, bilirubin or iron-binding compounds is protective in rodent disease models of ischemia-reperfusion injury, allograft and xenograft survival, intimal hyperplasia following balloon injury or as seen in chronic graft rejection and others. "
3.	Transplantation (Transplant Recipients) 02/01/2011 - "However, in a rodent disease model, the transplantation of differentiated cells derived from iPS cells ameliorated their symptoms. "
4.	Anesthesia 02/01/2012 - "However, ppTMS protocols in rodent disease models, where mechanistic insight into the ppTMS physiology and into disease processes may be obtained, have been limited due to the requirement for anesthesia and needle electromyography. "