Rocky Mountain Spotted Fever (Sao Paulo Typhus)

An acute febrile illness caused by RICKETTSIA RICKETTSII. It is transmitted to humans by bites of infected ticks and occurs only in North and South America. Characteristics include a sudden onset with headache and chills and fever lasting about two to three weeks. A cutaneous rash commonly appears on the extremities and trunk about the fourth day of illness.

Also Known As:

Networked: 158 relevant articles (6 outcomes, 7 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Fever (Fevers)
2.	Thrombocytopenia (Thrombopenia)
3.	Exanthema (Rash)
4.	Boutonneuse Fever (Mediterranean Spotted Fever)
5.	Bites and Stings (Sting)

Experts

1.	McQuiston, Jennifer H: 4 articles (05/2015 - 02/2014)
2.	Regan, Joanna J: 2 articles (05/2015 - 12/2014)
3.	Dahlgren, F Scott: 2 articles (05/2015 - 02/2014)
4.	Kato, Cecilia: 2 articles (12/2014 - 10/2014)
5.	Paddock, Christopher D: 2 articles (02/2010 - 04/2003)
6.	Buckingham, Steven C: 2 articles (11/2009 - 01/2005)
7.	Wikel, Stephen K: 2 articles (01/2009 - 01/2007)
8.	Alarcon-Chaidez, Francisco J: 2 articles (01/2009 - 01/2007)
9.	Martinez, Juan J: 1 article (12/2015)
10.	Cardwell, Marissa M: 1 article (12/2015)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Rocky Mountain Spotted Fever:

1.	VaccinesIBA 04/01/1986 - "rickettsii identified in this study may be important candidates for vaccines against Rocky Mountain spotted fever." 09/01/1976 - "New assay of protective activity of Rocky Mountain spotted fever vaccines." 02/01/1972 - "Preparation of vaccines for Rocky Mountain spotted fever from rickettsiae propagated in cell culture." 10/01/1948 - "Comparison of the immunogenic and anaphylactogenic properties of Rocky Mountain spotted fever vaccines prepared from infected yolk sacs and from infected tick tissue." 04/01/1984 - "Because the killed Rickettsia vaccines have failed to provide protection against Rocky Mountain spotted fever, we approached the problem of protective immunity to Rickettsia rickettsii with a closely related, live, less pathogenic spotted fever Rickettsia. "
2.	AntibodiesIBA 03/01/1991 - "Even though these sera did not contain antibodies to R rickettsii detectable by indirect fluorescent antibody testing, such false-positive results from serologic tests for Rocky Mountain spotted fever can obscure the patient's correct diagnosis. " 10/01/2014 - "Among 13 suspected Rocky Mountain spotted fever (RMSF) cases identified through an enhanced surveillance program in Tennessee, antibodies to Rickettsia rickettsii were detected in 10 (77%) patients using a standard indirect immunofluorescent antibody (IFA) assay. " 01/01/1988 - "All bobcats tested negative for serum antibodies to Rocky Mountain spotted fever (Rickettsia rickettsii). " 01/01/1986 - "This verifies the presence of this etiologic agent in ticks in an area where 6 people had clinical signs and symptoms of Rocky Mountain spotted fever (RMSF) and antibodies to R. " 05/01/1985 - "The prevalence of antibodies to Rickettsia rickettsii in an area endemic for Rocky Mountain spotted fever."
3.	Chloramphenicol (Chloromycetin)FDA Link 05/01/1979 - "He was treated with chloramphenicol for Rocky Mountain spotted fever, and recovered. " 09/01/1950 - "Further experience in the treatment of Rocky Mountain spotted fever with chloramphenicol." 12/01/1949 - "Chloromycetin therapy in Rocky Mountain spotted fever; report of two cases." 08/01/1949 - "Rocky Mountain spotted fever treated with chloromycetin; report of two cases." 10/01/1948 - "The treatment of Rocky Mountain spotted fever with chloromycetin."
4.	Doxycycline (Vibramycin)FDA LinkGeneric 05/01/2015 - "To evaluate whether cosmetically relevant dental effects occurred among children who had received doxycycline for treatment of suspected Rocky Mountain spotted fever (RMSF). " 05/01/2015 - "No visible dental staining in children treated with doxycycline for suspected Rocky Mountain Spotted Fever." 02/01/2014 - "Among 2012 Docstyle survey respondents, 80% identified doxycycline as the appropriate treatment for Rocky Mountain spotted fever in patients ≥ 8 years old, but only 35% correctly chose doxycycline in patients <8 years old. " 01/01/2005 - "Doxycycline is the antimicrobial treatment of choice for all patients, regardless of age, with Rocky Mountain spotted fever, human monocytic ehrlichiosis, or human granulocytic ehrlichiosis. " 12/01/1998 - "Empiric treatment with doxycycline can be lifesaving for Rocky Mountain spotted fever and ehrlichiosis. "
5.	Tetracycline (Achromycin)FDA LinkGeneric 07/01/1990 - "Should tetracycline be contraindicated for therapy of presumed Rocky Mountain spotted fever in children less than 9 years of age?" 02/01/1988 - "Rocky Mountain spotted fever is usually treated with the rickettsiostatic agents chloramphenicol or tetracycline, but few comparative data on these agents in patients with the disease are available. " 06/15/2005 - "Treatment with doxycycline or tetracycline is indicated for Rocky Mountain spotted fever, Lyme disease, ehrlichiosis, and relapsing fever. " 11/01/1991 - "Efficacy of chloramphenicol, enrofloxacin, and tetracycline for treatment of experimental Rocky Mountain spotted fever in dogs." 11/01/1991 - "Dogs were experimentally inoculated with Rickettsia rickettsii to characterize the comparative efficacies of chloramphenicol, enrofloxacin, and tetracycline for the treatment of Rocky Mountain spotted fever (RMSF). "
6.	SodiumIBA 11/01/1977 - "Experience with 138 cases of Rocky Mountain spotted fever indicates that the major clinical features of characteristic rash, fever, and tick bite, in combination with low serum sodium concentration and thrombocytopenia, are helpful in recognizing this serious and potentially lethal infectious disease." 11/01/1953 - "Reaction to diphenyl hydantoin sodium; report of a case simulating Rocky Mountain spotted fever and review of literature."
7.	PristinamycinIBA 12/01/1989 - "Roxithromycin and pristinamycin could be useful in the treatment of Rocky Mountain spotted fever and Mediterranean spotted fever."
8.	Azithromycin (Zithromax)FDA LinkGeneric 04/01/1999 - "Efficacy of doxycycline, azithromycin, or trovafloxacin for treatment of experimental Rocky Mountain spotted fever in dogs." 04/01/1999 - "Dogs were experimentally inoculated with Rickettsia rickettsii (canine origin) in order to compare the efficacies of azithromycin and trovafloxacin to that of the current antibiotic standard, doxycycline, for the treatment of Rocky Mountain spotted fever. "
9.	RoxithromycinIBA 12/01/1989 - "Roxithromycin and pristinamycin could be useful in the treatment of Rocky Mountain spotted fever and Mediterranean spotted fever."
10.	trovafloxacinIBA 04/01/1999 - "Efficacy of doxycycline, azithromycin, or trovafloxacin for treatment of experimental Rocky Mountain spotted fever in dogs." 04/01/1999 - "Dogs were experimentally inoculated with Rickettsia rickettsii (canine origin) in order to compare the efficacies of azithromycin and trovafloxacin to that of the current antibiotic standard, doxycycline, for the treatment of Rocky Mountain spotted fever. "

Therapies and Procedures

1.	Antibiotic Prophylaxis 01/01/1964 - "ANTIBIOTIC PROPHYLAXIS AND THERAPY OF ROCKY MOUNTAIN SPOTTED FEVER INITIATED IN MONKEYS VIA THE RESPIRATORY ROUTE."
2.	Elective Surgical Procedures 09/01/1997 - "We describe two patients who had Rocky Mountain spotted fever after they were admitted to the hospital for emergency and elective surgical procedures. "
3.	Heart Transplantation (Grafting, Heart) 06/01/1993 - "Rocky Mountain spotted fever following cardiac transplantation."
4.	Microspheres (Microsphere) 08/01/1980 - "A latex test for immunodiagnosis of Rocky Mountain spotted fever, using erythrocyte-sensitizing substance from Rickettsia rickettsii adsorbed to latex particles, has been developed. "
5.	Drug Therapy (Chemotherapy) 10/01/2002 - "To review the data regarding the pharmacotherapy of Lyme disease, Rocky Mountain spotted fever (RMSF), and the human ehrlichioses. "