2- Ethyl- 1,3,4,6,7,11b- hexahydro- 3- isobutyl- 9,10- dimethoxy- 2H-Benzo(a)quinolizin-2-ol

Proposed catecholamine depletor.

Also Known As:

2H-Benzo(a)quinolizin-2-ol, 2-Ethyl-1,3,4,6,7,11b-hexahydro-3-isobutyl-9,10-dimethoxy-; Ro 4-1284; Ro 41284; Ro4-1284; 2H-Benzo(a)quinolizin-2-ol, 2-ethyl-1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-

Networked: 10 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Quinolizines: 1
      - 2-Ethyl-1,3,4,6,7,11b-hexahydro-3-isobutyl-9,10-dimethoxy- 2H-Benzo(a)quinolizin-2-ol: 10
        GPA 1734: 1
        Ro 1-9564

Experts

1.	Cholanians, Aram B: 1 article (01/2015)
2.	Herndon, Joseph M: 1 article (01/2015)
3.	Lau, Serrine S: 1 article (01/2015)
4.	Lizarraga, Lucina E: 1 article (01/2015)
5.	Monks, Terrence J: 1 article (01/2015)
6.	Phan, Andy V: 1 article (01/2015)

Related Diseases

1.	Hypothermia 08/15/1979 - "The hypothermia was greater than that observed after reserpine or Ro 4-1284 and was not antagonized by imipramine at doses which significantly reduced immobility. " 01/15/1999 - "Ro4-1284 (2-Ethyl-1,3,4,6,7,11b-hexahydro-3-isobutyl-9,10-dimethoxy-2H-benzo[a] quinolizin-2-ol hydrochloride), a benzoquinolizine, is a potent dopamine depletion agent whose acute and chronic administration results in a (1) deterioration of learning in the Morris Water Maze and passive avoidance tasks, (2) decrease in locomotion and rearing, (3) intense hypothermia, and (4) decrease in the percentage of polyunsaturated fatty acids and an increase in the level of cholesterol in neuronal membranes. "
2.	Epilepsy (Aura) 05/04/1981 - "Effect of Ro 4-1284 on audiogenic seizure susceptibility and intensity in epilepsy-prone rats." 01/01/1988 - "Brain norepinephrine and convulsions in the genetically epilepsy-prone rat: sex-dependent responses to Ro 4-1284 treatment."
3.	Seizures (Absence Seizure) 12/01/1977 - "The data show that a significant decrease in spinal cord NE levels and a facilitating effect on spinal cord seizures are apparent 15 minutes after Ro 4-1284 (10 mg/kg s.c.) and that both of these effects persist for at least 24 hours. " 12/01/1977 - "The time course effects of the benzoquinolizine Ro 4-1284 on spinal cord norepinephrine (NE) and 5-hydroxytryptamine (5-HT) levels were compared to the effects of this same drug on electrically-induced spinal cord seizures. " 12/01/1977 - "Effects of Ro 4-1284 on electrically-induced spinal cord seizures and on spinal cord norepinephrine and 5-hydroxytryptamine levels."
4.	Hyperkinesis 04/01/1968 - "The effect of lithium and amphetamine on desmethylimipramine-Ro 4-1284 induced motor hyperactivity."
5.	Catalepsy 01/01/1976 - "However, the same dose of L-Dopa quickly reversed catalepsy when given at a time of dopamine depletion but in the absence of Ro 4-1284. " 01/01/1976 - "It was found that the injection of a small dose of L-Dopa did not reverse the catalepsy produced by the short-acting dopamine depleter, Ro 4-1284, either when the depleter was given alone or was given after tyrosine hydroxylase blockade by alpha-methyltyrosine, provided that the L-Dopa was given at a time when Ro 4-1284 was present. "

Related Drugs and Biologics

1.	Norepinephrine (Noradrenaline)
2.	Dopamine (Intropin)
3.	Amines
4.	alpha-Methyltyrosine (Metirosine)
5.	N-Methyl-3,4-methylenedioxyamphetamine (MDMA)
6.	Veratridine
7.	Tyrosine 3-Monooxygenase (Tyrosine Hydroxylase)
8.	Tyramine
9.	Serotonin (5 Hydroxytryptamine)
10.	Reserpine (Serpasil)