5S Ribosomal RNA

Constituent of the 50S subunit of prokaryotic ribosomes containing about 120 nucleotides and 34 proteins. It is also a constituent of the 60S subunit of eukaryotic ribosomes. 5S rRNA is involved in initiation of polypeptide synthesis.

Also Known As:

Networked: 57 relevant articles (0 outcomes, 3 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Zhong, Shuping: 7 articles (01/2020 - 01/2013)
2.	Shi, Ganggang: 4 articles (08/2017 - 11/2013)
3.	Levy, Daniel: 4 articles (02/2015 - 01/2013)
4.	Zhong, Qian: 4 articles (02/2015 - 01/2013)
5.	Zhang, Yanmei: 3 articles (08/2017 - 11/2013)
6.	Zhang, Qingsong: 3 articles (12/2014 - 01/2013)
7.	White, Robert J: 2 articles (05/2022 - 04/2008)
8.	Huang, Chenghao: 2 articles (01/2020 - 08/2017)
9.	Xia, Ningshao: 2 articles (01/2020 - 08/2017)
10.	Chen, Songlin: 2 articles (09/2017 - 08/2017)

Related Diseases

1.	Polyploidy 11/14/2017 - "The complex polyploid nature of the genome of bread wheat, Triticum aestivum, and the technically difficult task of sequencing clusters of tandem repeats mean that the detailed organization of extended genomic regions containing 5S rRNA genes remains unclear. " 05/25/2013 - "Species-genomic relationships among the tribasic diploid and polyploid Carthamus taxa based on physical mapping of active and inactive 18S-5.8S-26S and 5S ribosomal RNA gene families, and the two tandemly repeated DNA sequences." 06/01/2004 - "Data is presented on the evolutionary dynamics of non-transcribed spacers (NTSs) of 5S rRNA genes in some diploid and polyploid Triticum and Aegilops species. " 03/01/1989 - "[Nucleotide sequences of 5S rRNA genes of polyploid species of wheat and Aegilops species]." 03/01/2010 - "To complete our study of the genus Hordeum and to elaborate a phylogeny of species based upon 5S rDNA sequences, we have cloned and sequenced PCR amplicons from seven American polyploid species to generate 164 new 5S rRNA gene sequences. "
2.	Tetraploidy 01/01/2021 - "In this study, the chromosomal organizations and distributions of six repetitive DNA sequences (including three SSR motifs (TTC, AAC, CAG), one 5S rRNA gene fragment, and two oat A and C genome specific repeats) were investigated using non-denaturing fluorescence in situ hybridization (ND-FISH) in the three tetraploid species mentioned above and in two hexaploid oat species. " 06/01/1997 - "The positions of the 18S-5.8S-26S and 5S rRNA genes have been physically mapped on the chromosomes of diploid, tetraploid, and hexaploid Festuca species by in situ hybridization. " 08/01/2005 - "We used the intergenic spacer sequences of the 5S ribosomal RNA genes (5S rDNA) to obtain insights into the genomic origin of putative amphidiploid/tetraploid species with 2n = 48 and their descendants in Nicotiana. "
3.	Esophageal Squamous Cell Carcinoma 12/21/2015 - "In this study, we found that 5S rRNA is a direct target of miR-150 and miR-383 in esophageal squamous cell carcinoma (ESCC). " 01/01/2017 - "However, expression levels of 18s rRNA, GAPDH, P4HB, 5s rRNA, U6, and RNU6B varied greatly between esophageal normal and squamous cell carcinoma samples, indicating that they are not suitable for use as references in the qRT-PCR analysis of esophageal squamous cell carcinoma."
4.	Neoplasms (Cancer) 02/21/2017 - "Perturbation of RRP15 induces nucleolar stress that activates RPL5/RPL11/5S rRNA (RP)-Mdm2-p53 axis checkpoint response and arrests cells at G1-G1/S in p53-proficient non-transformed RPE1 cells but not in p53-deficient HeLa and MCF7 tumor cells. " 12/21/2015 - "5S rRNA plays an important part in ribosome biology and is over-expression in multiple cancers. " 01/01/2020 - "Our results shed light on the so-far enigmatic role of cancer-associated mutations in genes encoding ribosomal proteins, with implications for our understanding of the tumor suppressive role of the RPL5/RPL11/5S rRNA complex in human malignancies." 08/30/2017 - "RNA polymerase III-dependent genes (Pol III genes) deregulation elevates cellular production of tRNAs and 5S rRNA, resulting in an increase in translational capacity, which promote cell transformation and tumor formation. " 12/15/2014 - "Deregulation of RNA polymerase III-dependent (Pol III) transcription enhances cellular tRNAs and 5S rRNA production, leading to an increase in translational capacity to promote cell transformation and tumor formation. "
5.	Infections 01/01/2018 - "Using next-generation RNA sequencing (RNAseq), we found that host-derived RNAs, most prominently 5S ribosomal RNA pseudogene 141 (RNA5SP141), bound to RIG-I during infection with herpes simplex virus 1 (HSV-1). " 10/01/1998 - "However, as observed during wt VSV infection, M protein enhanced endogenous 5S rRNA transcription, indicating that the inhibition of transcription by RNAPIII was dependent on the nature of the promoter." 01/01/2019 - "In addition, TBEV infection resulted in a specific decrease of RNA polymerase I (POLR1) transcripts, 18S and 28S rRNAs and their precursor, 45-47S pre-rRNA, but had no effect on the POLR3 transcribed 5S rRNA levels. " 10/01/1998 - "Nuclear runoff analysis showed that VSV inhibited transcription of 18S rRNA and alpha-tubulin genes, which was dependent on RNAPI and RNAPII, respectively, but infection with wt virus enhanced transcription of 5S rRNA by RNAPIII. " 05/01/1998 - "Adenovirus type 12 (Ad12) infection of human cells induces four chromosomal fragile sites corresponding to the U1 small nuclear RNA (snRNA) genes (the RNU1 locus), the U2 snRNA genes (RNU2), the U1 snRNA pseudogenes (PSU1), and the 5S rRNA genes (RN5S). "

Related Drugs and Biologics

1.	Ribosomal DNA (rDNA)
2.	RNA Polymerase III
3.	DNA-Directed RNA Polymerases (RNA Polymerase)
4.	RNA (Ribonucleic Acid)
5.	Transfer RNA (tRNA)
6.	18S Ribosomal RNA
7.	Proteins (Proteins, Gene)
8.	DNA (Deoxyribonucleic Acid)
9.	Leu Transfer RNA
10.	Small Nuclear RNA (snRNA)

Related Therapies and Procedures

1.	Lasers (Laser)