Ribosomal RNA

The most abundant form of RNA. Together with proteins, it forms the ribosomes, playing a structural role and also a role in ribosomal binding of mRNA and tRNAs. Individual chains are conventionally designated by their sedimentation coefficients. In eukaryotes, four large chains exist, synthesized in the nucleolus and constituting about 50% of the ribosome. (Dorland, 28th ed)

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Networked: 537 relevant articles (9 outcomes, 39 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Hannan, Ross D: 6 articles (01/2020 - 02/2011)
2.	Diaz, Jean-Jacques: 4 articles (03/2021 - 01/2020)
3.	Marcel, Virginie: 4 articles (03/2021 - 01/2020)
4.	Hannan, Katherine M: 4 articles (01/2020 - 11/2013)
5.	Pearson, Richard B: 4 articles (01/2020 - 11/2013)
6.	Sanij, Elaine: 4 articles (01/2020 - 02/2011)
7.	Nomoto, Koji: 4 articles (01/2017 - 07/2010)
8.	Ibaragi, Soichiro: 4 articles (05/2014 - 05/2011)
9.	Kishimoto, Koji: 4 articles (05/2014 - 09/2006)
10.	Yoshioka, Norie: 4 articles (05/2014 - 09/2006)

Related Diseases

1.	Neoplasms (Cancer) 04/15/2019 - "Based on the morphological study of the cultured organelle obtained by tumor enucleation and the internal transcribed spacer sequence of ribosomal RNA, the pathogen was identified as C. " 09/01/1975 - "Studies on isolated nucleoli showed that the in vitro addition of polyinosinate and several other compounds actively inhibited tumor ribosomal RNA methylases but were devoid of inhibitory effect against liver ribosomal RNA methylases; these results augment other studies in the literature in suggesting a selective effect of the polyinosinate moiety on tumor cells. " 01/01/1966 - "[Studies on the structure of ribosomal RNA from normal and tumor tissues. " 01/01/1965 - "[STUDIES ON THE STRUCTURE OF RIBOSOMAL RNA IN NORMAL AND TUMOR TISSUES. " 12/01/1964 - "[STUDIES ON THE STRUCTURE OF RIBOSOMAL RNA FROM NORMAL AND TUMOR TISSUES. "
2.	Infections 03/01/2011 - "Time to clearance of Chlamydia trachomatis ribosomal RNA in women treated for chlamydial infection." 11/01/1991 - "To confirm and study such infections, we developed a hybridization screening system directed toward chlamydial ribosomal RNA (rRNA). " 04/30/2021 - "Blood samples were collected from 227 cattle and tested for infection with trypanosomes using microscopy and Ribosomal RNA Internal Transcribed Spacers (ITS)-PCR. " 01/01/2020 - "This activity is likely directed towards both viral and ribosomal RNA, explaining the almost complete abolition of infection when virus and RIP enter together into the cells." 01/01/2020 - "Unexpected features in Tupanviruses is the cytotoxic effect observed during infection, where the virus degrades the ribosomal RNA (rRNA) of its amoebal host. "
3.	Malaria 07/01/2010 - "Malaria parasite detection was made by the gold standard (microscopy) and also nested-PCR assay, using 18S small sub-unit ribosomal RNA (ssrRNA) gene. " 04/01/1996 - "To study the mechanisms involved in this striking difference in the infectivity of these closely related species of malaria parasites, we have developed a quantitative PCR targeted to parasite-specific ribosomal RNA. " 01/01/2021 - "Conclusion: Malaria detection in areas of low transmission and LDMI can benefit from the increased sensitivity of ribosomal RNA detection by RT-PCR, especially where sample volume is limited. " 01/01/2021 - "Conclusion: Malaria detection in areas of low transmission and LDMI can benefit from the increased sensitivity of ribosomal RNA detection by RT-PCR, especially where sample volume is limited. " 01/01/2021 - "Conclusion: Malaria detection in areas of low transmission and LDMI can benefit from the increased sensitivity of ribosomal RNA detection by RT-PCR, especially where sample volume is limited. "
4.	Mycoses (Diseases, Fungus) 12/01/2009 - "We established a nested PCR assay that uses two pairs of PCR primers to amplify the internal transcribed spacer (ITS) region of a ribosomal RNA cassette to detect mild fungal infections from as little as 0.001 pg (1 fg) of B. " 09/01/2006 - "Single-stranded conformation polymorphism of large subunit of ribosomal RNA is best suited to diagnosing fungal infections and differentiating fungi at species level." 09/01/1995 - "The controversy about the appropriate taxonomic placement of agents of subcutaneous and systemic mycoses in either Cladosporium or Xylohypha, both genera characterized by conidia being produced in dry, acropetal chains, was addressed with partial sequencing of LS ribosomal RNA. " 08/01/2004 - "Improved laboratory diagnosis of bacterial and fungal infections in patients with hematological malignancies using PCR and ribosomal RNA sequence analysis." 01/01/2013 - "In this study, we investigated (99m)Tc labeled MORF oligomers targeting fungal ribosomal RNA (rRNA) for the imaging detection of fungal infections. "
5.	Cicatrix (Scar) 07/01/2012 - "For example, recent studies with ribosomal RNA-based nucleic acid amplification tests (NAATs) have demonstrated improved sensitivities compared to DNA-based NAATs; and the progression of scarring has now been characterized with confocal microscopy. "

Related Drugs and Biologics

1.	CX 5461
2.	DNA (Deoxyribonucleic Acid)
3.	Nucleic Acids
4.	Anti-Bacterial Agents (Antibiotics)
5.	Aminoglycosides
6.	Azithromycin (Zithromax)
7.	Methyltransferases
8.	Proteins (Proteins, Gene)
9.	Paraffin
10.	RNA (Ribonucleic Acid)

Related Therapies and Procedures

1.	Oral Administration
2.	Therapeutics
3.	Resistance Training
4.	Neoadjuvant Therapy
5.	Esophagectomy