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RNA Replicase (RNA Dependent RNA Polymerase)

Subscribe to New Research on RNA Replicase

An enzyme that catalyses RNA-template-directed extension of the 3'- end of an RNA strand by one nucleotide at a time, and can initiate a chain de novo. (Enzyme Nomenclature, 1992, p293)

Also Known As:

RNA Dependent RNA Polymerase; RNA-Directed RNA Polymerase; RNA Directed RNA Polymerase; RNA Polymerase, RNA-Dependent; RNA Polymerase, RNA-Directed; Replicase, RNA; RNA-Dependent RNA Polymerase; Nucleoside-triphosphate:RNA nucleotidyltransferase (RNA-directed)

Networked: 258 relevant articles (1 outcomes, 11 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Jiang, Daohong: 6 articles (02/2015 - 05/2003)
2.	Cheng, Jiasen: 5 articles (02/2015 - 05/2003)
3.	Fu, Yanping: 5 articles (02/2015 - 05/2003)
4.	Ogino, Tomoaki: 5 articles (10/2014 - 01/2007)
5.	Xie, Jiatao: 4 articles (02/2015 - 09/2011)
6.	Valles, Steven M: 4 articles (01/2014 - 09/2007)
7.	Digiaro, Michele: 4 articles (03/2013 - 05/2011)
8.	Elbeaino, Toufic: 4 articles (03/2013 - 05/2011)
9.	Ghabrial, Said A: 4 articles (09/2011 - 05/2003)
10.	Banerjee, Amiya K: 4 articles (02/2010 - 04/2002)

Related Diseases

1.	Infection 01/01/2014 - "Incidence of and factors associated with false positives in laboratory diagnosis of norovirus infection by amplification of the RNA-dependent RNA polymerase gene." 04/01/2013 - "SCE1, the SUMO-conjugating enzyme in plants that interacts with NIb, the RNA-dependent RNA polymerase of Turnip mosaic virus, is required for viral infection." 02/01/2013 - "The major clinical symptoms associated with HCoV-HKU1 infection were examined statistically and sequence variations of the RNA-dependent RNA polymerase (RdRp), spike, and nucleocapsid genes were also analyzed. " 06/10/2012 - "Genome-wide identification of Dicer-like, Argonaute and RNA-dependent RNA polymerase gene families and their expression analyses in response to viral infection and abiotic stresses in Solanum lycopersicum." 03/01/2012 - "Filibuvir (PF-00868554) is an investigational nonnucleoside inhibitor of the hepatitis C virus (HCV) nonstructural 5B (NS5B) RNA-dependent RNA polymerase currently in development for treating chronic HCV infection. "
2.	Neoplasms (Cancer) 04/01/2012 - "In the present study, the feasibility of further improving the anti-tumor activity of the RNA replicase-based plasmid by targeting it into tumors cells was evaluated. " 04/01/2012 - "Tumor-targeted RNA replicase-based plasmids hold a strong potential in tumor therapy." 04/01/2012 - "Previously, it was shown that treatment of tumor-bearing mice with an RNA replicase-based plasmid that produces dsRNA when transfected into tumor cells significantly inhibited the tumor growth. " 07/01/2011 - "These include an RNA-dependent RNA polymerase (RdRp), a coat protein, an undefined replication-related protein and an ovarian tumor domain peptidase. " 01/01/2011 - "RNA replicase-based plasmid may be exploited to generate intracellular dsRNA to control tumor growth."
3.	Gastroenteritis 12/01/2006 - "In this study, we assessed the prevalence of human NoV in Italian children with gastroenteritis by using a reverse-transcription nested polymerase chain reaction (RT-PCR) assay specific for the RNA-dependent RNA polymerase (RdRp) on faecal samples collected throughout the 2004 surveillance activity in Palermo, Italy. " 12/01/1995 - "This technique, using primers directed to the RNA-dependent RNA polymerase region within the ORF1 of NV, was used to characterise SRSVs associated with epidemic gastroenteritis in adults and sporadic paediatric gastroenteritis in South Africa. " 03/01/2004 - "This study describes the application of a reverse transcription-polymerase chain reaction (RT-PCR) assay using random primers (PdN6) and specific Ni and E3 primers, directed at a small region of the RNA-dependent RNA polymerase-coding region of the norovirus genome, and DNA sequencing for the detection and preliminary characterisation of noroviruses in outbreaks of gastroenteritis in children in Brazil. " 01/01/2012 - "Transmissible gastroenteritis coronavirus RNA-dependent RNA polymerase and nonstructural proteins 2, 3, and 8 are incorporated into viral particles." 10/01/2011 - "We show that Akt, an important signaling kinase involved in cell survival, phosphorylates the RNA-dependent RNA polymerase (RdRp) from norovirus, the major cause of gastroenteritis outbreaks worldwide. "
4.	Human Influenza (Influenza) 04/03/2015 - "The influenza RNA-dependent RNA polymerase is a core enzyme required for both transcription and replication of the virus RNA genome, making it a potential drug target for the influenza virus. " 12/12/2013 - "Influenza RNA-Dependent RNA Polymerase (RdRp) Inhibitors: Potential New Therapy for Influenza Treatment." 05/01/2013 - "Although the nucleic acid-based techniques are highly sensitive and specific, the high mutation rate of the influenza RNA-dependent RNA polymerase could limit the utility of the techniques. " 11/09/2010 - "Several antiinfluenza compounds were inhibitory to the influenza RNA-dependent RNA polymerase (RdRP), including nucleozin and its analogs. " 11/09/2010 - "High-throughput identification of compounds targeting influenza RNA-dependent RNA polymerase activity."
5.	Vesicular Stomatitis 12/01/2002 - "The large (L) protein of vesicular stomatitis virus (VSV), catalytic subunit of RNA-dependent RNA polymerase is responsible for the transcription and replication of VSV. " 09/13/2002 - "Transcriptional control of the RNA-dependent RNA polymerase of vesicular stomatitis virus." 02/01/1992 - "The phosphoprotein (P) and the large protein (L) constitute the RNA-dependent RNA polymerase of vesicular stomatitis virus (VSV). " 05/25/1978 - "The RNA-dependent RNA polymerase associated with vesicular stomatitis virus has been found to be markedly inhibited at high concentrations of virus. " 03/01/1974 - "The presence of a virion-associated RNA-dependent RNA polymerase in five serologically distinct rhabdovirus isolates (vesicular stomatitis virus [VSV] Indiana, VSV New Jersey, Cocal, Chandipura, and Piry viruses) has been demonstrated. "

Related Drugs and Biologics

1.	Antiviral Agents (Antivirals)
2.	Serine Proteases (Serine Protease)
3.	DNA (Deoxyribonucleic Acid)
4.	Complementary RNA (cRNA)
5.	Antisense RNA (Anti-Sense RNA)
6.	RNA Polymerase I (Polymerase I, RNA)
7.	Luciferases
8.	Chikungunya virus infection
9.	ethyl acetate
10.	RNA (Ribonucleic Acid)

Related Therapies and Procedures

1.	Therapeutics
2.	Dilatation and Curettage (D&C)
3.	Canes (Cane)