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RNA Precursors (Precursor, mRNA)

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RNA transcripts of the DNA that are in some unfinished stage of post-transcriptional processing (RNA PROCESSING, POST-TRANSCRIPTIONAL) required for function. RNA precursors may undergo several steps of RNA SPLICING during which the phosphodiester bonds at exon-intron boundaries are cleaved and the introns are excised. Consequently a new bond is formed between the ends of the exons. Resulting mature RNAs can then be used; for example, mature mRNA (RNA, MESSENGER) is used as a template for protein production.

Also Known As:

Precursor, mRNA; Pre-mRNA; Pre-rRNA; Pre-snRNA; Pre-tRNA; Primary Transcript, RNA; RNA Precursor; mRNA Precursor; rRNA Precursor; snRNA Precursor; tRNA Precursor; Pre mRNA; Pre rRNA; Pre snRNA; Pre tRNA; Precursor, RNA; Precursor, rRNA; Precursor, snRNA; Precursor, tRNA; Precursors, RNA; RNA Primary Transcript; RNA Transcript, Primary; RNA, Precursor; Transcript, Primary RNA; Transcript, RNA Primary; Precursor RNA; Primary RNA Transcript; RNA, Messenger, Precursors; RNA, Ribosomal, Precursors; RNA, Small Nuclear, Precursors; RNA, Transfer, Precursors

Networked: 597 relevant articles (6 outcomes, 36 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Nucleic Acids, Nucleotides, and Nucleosides: 1
- Nucleic Acids: 1996
  - RNA: 31229
    - RNA Precursors: 597
- Nucleic Acid Precursors: 31
  - RNA Precursors: 597

Experts

1.	Kole, Ryszard: 10 articles (07/2012 - 09/2002)
2.	Liu, Ying: 5 articles (09/2014 - 05/2011)
3.	Thornton, Charles A: 5 articles (01/2013 - 07/2002)
4.	Mayeda, Akila: 5 articles (09/2012 - 02/2004)
5.	Manabe, Takayuki: 5 articles (12/2010 - 04/2003)
6.	Zhao, Chen: 4 articles (01/2015 - 04/2005)
7.	Bhattacharya, Shomi S: 4 articles (10/2014 - 01/2002)
8.	He, Johnny J: 4 articles (09/2014 - 05/2011)
9.	Corcos, Laurent: 4 articles (01/2014 - 01/2004)
10.	Manley, James L: 4 articles (11/2013 - 05/2005)

Related Diseases

1.	Duchenne Muscular Dystrophy (Muscular Dystrophy, Becker) 08/01/2007 - "Cell-penetrating peptide-morpholino conjugates alter pre-mRNA splicing of DMD (Duchenne muscular dystrophy) and inhibit murine coronavirus replication in vivo." 05/01/1996 - "Modulation of pre-mRNA splicing in the Duchenne muscular dystrophy gene." 02/01/2014 - "In particular, the use of AONs for exon skipping, by targeting pre-mRNA, is proving to be a highly promising therapy for some genetic disorders like Duchenne muscular dystrophy and spinal muscular atrophy. " 10/01/2006 - "Antisense oligonucleotide (AO) manipulation of pre-mRNA splicing of the dystrophin gene is showing promise in overcoming Duchenne muscular dystrophy (DMD)-causing mutations. " 01/01/2015 - "Studies to date have focused on the delivery of a single SSO conjugated to a CPP, but here we describe the conjugation of two phosphorodiamidate morpholino oligonucleotide (PMO) SSOs to a single CPP for simultaneous delivery and pre-mRNA targeting of two separate genes, exon 23 of the Dmd gene and exon 5 of the Acvr2b gene, in a mouse model of Duchenne muscular dystrophy. "
2.	Neoplasms (Cancer) 02/01/2015 - "Recent studies have established the importance of pre-mRNA alternative splicing (AS) in cancer biology. " 01/01/2015 - "Here we review recent studies on the role of SAM68 in splicing regulation and we discuss its contribution to aberrant pre-mRNA processing in cancer." 01/01/2013 - "Accordingly, this study demonstrates an extensive AS of REST pre-mRNA which redefines REST gene boundary and structure, along with a general but differential link between REST pre-mRNA splicing and various types of cancer. " 05/01/2012 - "In this study, we examined the elusive prosurvival signaling pathways that regulate the 5'SS selection of Bcl-x pre-mRNA in cancer cells. " 11/01/2011 - "We present here a study of AhR gene polymorphism in normal and cancer human tissues affecting pre-mRNA splicing in the AhR gene-coding transactivation domain region (exon 10, intron 10, exon 11 region), previously shown to be associated with AhR dysfunction. "
3.	Carcinoma (Carcinomatosis) 01/05/2015 - "In human colon carcinoma cells, HCT116, the production rate of 47S rRNA precursor transcripts was dramatically reduced as an early event after drug treatment. " 11/15/2015 - "BCAS2 (breast carcinoma amplified sequence 2), a core component of the PRP19 complex involved in pre-mRNA splicing, plays an important role in the DNA damage response through the RPA complex, a key regulator in the maintenance of genome integrity. " 01/11/2001 - "PRCC, the commonest TFE3 fusion partner in papillary renal carcinoma is associated with pre-mRNA splicing factors." 01/01/1979 - "The nature of the 5'-termini in pre-mRNA isolated from Ehrlich carcinoma cells has been investigated. " 03/01/1974 - "Isolation of oligonucleotide fragments containing the 5'-ends of nuclear pre-mRNA of Ehrlich carcinoma cells."
4.	Hypercholesterolemia 05/01/2015 - "For this purpose, a new RNA therapeutic approach for hypercholesterolemia based on SSOs was developed for modulation of the splice pattern of human PCSK9 pre-mRNA. " 01/01/2016 - "Antisense oligonucleotide (AON)-mediated splice modulation appears to be a powerful approach to correct the consequences of such mutations at the pre-mRNA level , as demonstrated by promising results in clinical trials for several inherited disorders like Duchenne muscular dystrophy, hypercholesterolemia and various types of cancer. "
5.	Spinal Muscular Atrophy (Progressive Muscular Atrophy) 03/01/2011 - "Prevention of skipping of exon 7 during pre-mRNA splicing of Survival Motor Neuron 2 (SMN2) holds the promise for cure of spinal muscular atrophy (SMA), a leading genetic cause of infant mortality. " 07/01/2010 - "Repair of pre-mRNA splicing: prospects for a therapy for spinal muscular atrophy." 11/25/1998 - "A novel function for SMN, the spinal muscular atrophy disease gene product, in pre-mRNA splicing." 02/01/2014 - "In particular, the use of AONs for exon skipping, by targeting pre-mRNA, is proving to be a highly promising therapy for some genetic disorders like Duchenne muscular dystrophy and spinal muscular atrophy. " 08/11/2015 - "In this report, we show that U2AF(65) stimulates alternative exon skipping in spinal muscular atrophy (SMA)-related survival motor neuron (SMN) pre-mRNA. "

Related Drugs and Biologics

1.	Dystrophin
2.	Sepharose (Agarose)
3.	Messenger RNA (mRNA)
4.	RNA (Ribonucleic Acid)
5.	RNA Splice Sites
6.	Proteins (Proteins, Gene)
7.	Protein Isoforms (Isoforms)
8.	Arginine (L-Arginine)
9.	Serine (L-Serine)
10.	Amyloid (Amyloid Fibrils)

Related Therapies and Procedures

1.	Sutures (Suture)
2.	Heterologous Transplantation (Xenotransplantation)
3.	Immunomodulation
4.	Therapeutics
5.	Surgical Instruments (Clip)