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Rimantadine

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An RNA synthesis inhibitor that is used as an antiviral agent in the prophylaxis and treatment of influenza.

Also Known As:

Flumadine; Forest Brand of Rimantadine Hydrochloride; Riamantadine; Rimantadine Hydrochloride; Roche Brand of Rimantadine Hydrochloride; Roflual; Hydrochloride, Rimantadine; Remantadine; Tricyclo(3.3.1.13,7)decane-1-methanamine, alpha-methyl-

Networked: 343 relevant articles (50 outcomes, 36 trials/studies)

Relationship Network

Drug Context: Research Results

Organic Chemicals: 58
- Hydrocarbons: 412
  - Cyclic Hydrocarbons: 3
    - Bridged Compounds: 3
      - Adamantane: 103
        Rimantadine: 343
        adapromine: 2
        polirem: 1
    - Alicyclic Hydrocarbons: 1
      - Cycloparaffins: 5
        Adamantane: 103
        Rimantadine: 343
        adapromine: 2
        polirem: 1

Experts

1.	Demicheli, V: 7 articles (01/2006 - 01/2000)
2.	Rivetti, D: 7 articles (01/2006 - 01/2000)
3.	De Clercq, Erik: 6 articles (10/2015 - 05/2003)
4.	Burtseva, E I: 6 articles (06/2012 - 03/2007)
5.	Shevchenko, E S: 5 articles (06/2012 - 03/2007)
6.	L'vov, D K: 5 articles (01/2012 - 07/2005)
7.	Fediakina, I T: 5 articles (01/2012 - 07/2005)
8.	Hayden, F G: 5 articles (08/2002 - 03/2000)
9.	Shchelkanov, M Iu: 4 articles (03/2014 - 03/2006)
10.	Chou, James J: 4 articles (06/2013 - 03/2010)

Related Diseases

1.	Human Influenza (Influenza) 09/01/1990 - "These findings indicate that low-dose rimantadine is well tolerated and highly effective for the prevention of influenza A illness in healthy adults." 10/14/1988 - "A gas chromatographic-mass spectrometric procedure has been developed for the quantitation in plasma and urine of the enantiomers of rimantadine, an antiviral drug effective against type A influenza. " 10/01/1987 - "A GC-MS procedure has been developed for the quantitation in plasma and urine of rimantadine, an antiviral drug effective against type A influenza. " 05/01/1978 - "The therapeutic and prophylactic efficacy of rimantadine in familial foci during influenza A1 outbreaks was studied. " 05/01/1969 - "The therapeutic efficacy of rimantadine HC1 in a naturally occurring influenza A2 outbreak."
2.	Infection 12/01/2004 - "Maximum synergy against A/New Caledonia/20/99 (H1N1) virus infection was observed with <2.5 microM rimantadine paired with low concentrations of NA inhibitors. " 10/01/2003 - "Thus, rimantadine should be the preferred agent in this class for the prevention of influenza A virus infection and should be made available in Canada." 10/01/2003 - "A case for rimantadine to be marketed in Canada for prophylaxis of influenza A virus infection." 05/01/1999 - "Sensitivity to rimantadine is higher in a variant obtained similarly by cell culture infection with rimantadine-resistant FPV. " 04/01/1997 - "Combined protective effect of an immunostimulatory bacterial preparation and rimantadine in experimental influenza A virus infection."
3.	Fever (Fevers) 01/01/2014 - " treatment, rimantadine was beneficial in abating fever on day three of treatment in children: one selected study with low risk of bias, moderate evidence quality and 69 participants (RR 0.36; 95% CI 0.14 to 0.91). " 08/01/1987 - "Children receiving rimantadine showed significantly greater reduction in fever and improvement in daily scores for symptoms and severity of illness during the first three days. " 09/01/1991 - "In a family-based study, rimantadine treatment for 10 days (24 children and adults) was associated with significant decreases in the number of days to a 50% reduction in symptoms (mean difference, 2.5 days), days of fever (1.6 days), and days of restricted activity (1.5 days) compared with the results obtained with placebo-treated patients (32 children and adults). " 01/06/2000 - "73-1.29), and oral rimantadine significantly shortened duration of fever (by 1.27 days - 95%CI: 0.77-1.77). " 01/01/1994 - "Remantadine application decreased fever and complication rates and reduced the duration of intoxication symptoms and the diseases as a whole. "
4.	Influenza in Birds (Avian Flu) 05/01/2010 - "TZV was also effective against a rimantadine-resistant influenza virus strain and against avian influenza A virus H5N1 strains. " 09/01/2005 - "The fear that avian influenza could be a precursor to the next pandemic is real and inevitable, given the extremely high case-fatality ratio among confirmed cases and that genetic sequencing of influenza A (H5N1) viruses from human cases in Thailand and Vietnam show resistance to the antiviral medication amantadine and rimantadine. " 03/01/1985 - "Virion deproteinization and viral RNA transport to the isolated cell nuclei have been studied in the presence of rimantadine with rimantadine-sensitive influenza viruses fowl plague (H7N7), A/Krasnodar/101/59 (H2N2) and rimantadine-resistant influenza strains (WSN/H1N1 and A/Krasnodar/101/59-R). " 03/01/2006 - "Commercial drugs, such as rimantadine, amantadine, rivabirine, and arbidole, are effective in suppressing the in vitro reproduction of highly pathogenic avian influenza A/H5N1 viruses. " 07/01/2005 - "The antiviral agents rimantadine, ribavirine, and tamiflu were tested for the effects on the reproduction of avian influenza virus A/H5 in in vitro experiments. "
5.	Pneumonia (Pneumonitis) 09/01/1987 - "In the groups of mice infected with remantadine-resistant strain of influenza virus and Staphylococcus remantadine showed no significant effect on these parameters: the lethality decreased by 6.7% only, the average survival time increased only by 0.33 days, the incidence of pneumonia decreased by 9%, its intensity by 19.2%; influenza virus titres in the lung tissue did not change significantly." 09/01/1987 - "When the drug was injected to the mice infected with remantadine-sensitive strain of influenza A virus and Staphylococcus the lethality decreased from 93.3% to 26.7%, the survival time increased from 3.8 to 10.1 days, the incidence of pneumonia decreased from 85.7% to 48.7%, the average intensity of pneumonia decreased from 66.4% to 9.9%, and virus titres in the lungs decreased by 3.5-4.0 lg EID50 (p less than 0.05). " 01/01/1980 - "[Prevention of pneumonia in influenza A by means of a new anti-influenza drug rimantadine]." 11/01/2004 - "Six untreated patients (18%) developed pneumonia, whereas 1 (13%) of 8 patients treated with rimantadine and 0 of 9 treated with oseltamivir developed pneumonia. " 06/01/2001 - "Antiviral treatment was begun 4 +/- 3 days from initiation of symptoms in patients with pneumonia and consisted of oseltamivir (35.2%), rimantadine (5.8%), or a combination of both (17.6%). "

Related Drugs and Biologics

1.	Amantadine (Aman)
2.	Antiviral Agents (Antivirals)
3.	Zanamivir (Relenza)
4.	Oseltamivir (Tamiflu)
5.	Neuraminidase (Sialidase)
6.	arbidol
7.	Ion Channels (Ion Channel)
8.	Ribavirin (Virazole)
9.	Influenza Vaccines (FluMist)
10.	peramivir

Related Therapies and Procedures

1.	Chemoprevention
2.	Drug Therapy (Chemotherapy)
3.	Long-Term Care
4.	Transplants (Transplant)
5.	Home Nursing (Nursing, Home)