Rickettsia Infections

01/01/2011 - "Antibiotic treatment remains effective in the management of Rickettsia infection."
01/01/1951 - "[Contribution to the study of rickettsial diseases in Oubangui-Chari following brush fire; 4 new cases in Bangui; clinical cases, serological behavior, isolation of strains; spectacular results of antibiotics]."
10/01/2022 - "Early clinical diagnosis of rickettsial disease, while awaiting laboratory test results, is essential for prompt initiation of appropriate antibiotic treatment to prevent systemic and ocular morbidity. "
10/01/2019 - "Familiarizing clinicians with the presentation of rickettsiosis-associated septic syndromes and its early and appropriate antibiotic treatment can provide lifesaving care and reduce health-care costs through prevention of the morbidity associated with FBT."
03/06/2018 - "There is a need to emphasize the screening of rickettsioses to medical personnel and to encourage the use of appropriate antibiotics as early treatment for nonspecific febrile illnesses in this region. "

07/15/2007 - "This led to the evaluation of chloramphenicol for the treatment of rickettsial diseases and typhoid fever. "
07/01/1948 - "Chloromycetin; an antibiotic effective in the treatment of rickettsial diseases."
11/01/1949 - "Aureomycin and chloromycetin have now been used in a number of viral and rickettsial diseases and have gone far toward fulfilling their original promise. "
09/08/1949 - "Clinical use of aureomycin and chloromycetin in rickettsia infections."
03/01/1949 - "Chloromycetin has been demonstrated to be an effective antibiotic agent for the treatment of rickettsial diseases and typhoid fever. "

06/01/2022 - "Further serological studies using other Rickettsia spp. antigens, as well as molecular studies that search for Rickettsia spp. in humans, animals and arthropods are needed to obtain more comprehensive data on rickettsiosis in northern Cyprus."
06/01/1978 - "The method is recommended for detection at the territory under study of circulation of the causative agent of tick-borne rickettsiosis by revealing the specific antigen in bird pellets."
08/01/2017 - "Weil Felix test is useful in diagnosis; however, there is cross reactivity between various antigens of the test, hence differentiation into various groups of rickettsiosis should not be done based on Weil Felix test alone."
07/01/2009 - "conorii, and the truncated recombinant antigens could be used for development of diagnostic tools for rickettsial disease."
05/01/2004 - "Definite microbiological confirmation of tick-borne rickettsioses by isolation or antigen detection is only available at reference laboratories and diagnosis must in most cases rely on clinical and epidemiological data supported by serology. "

01/01/2005 - "RMSF is an important rickettsial disease and is effectively treated with doxycycline. "
02/01/2023 - "felis rickettsiosis is self-limiting and easily treated with doxycycline, but its diagnosis remains a challenge. "
01/01/2023 - "Thorough history, examination, and timely treatment with doxycycline should be considered if there is suspicion of Rickettsia infection before testing."
11/01/2022 - "Doxycycline is recommended for use in rickettsial diseases. "
01/27/2022 - "Doxycycline remains the key treatment of rickettsiosis. "

11/15/2004 - "Tetracyclines are the drugs of first choice and should be prescribed whenever a case of rickettsiosis is suspected. "
12/01/1992 - "Ehrlichiosis in humans, a rickettsial disease recently discovered in the United States, is generally treated successfully with tetracyclines; however treatment with these agents is usually avoided with children and pregnant women. "
01/01/2004 - "As the infection was treated easily with tetracyclines, clinical diagnosis was considered to be rickettsiosis or ehrlichiosis. "
01/01/2020 - "Although the antibiotic sensitivity profile of Trichorickettsia seems to resemble that of other representatives of Rickettsiaceae, causative agents of severe diseases in humans, neither of the antibiotic treatments used in this study resulted in an aposymbiotic cell line, apparently, due to the protists' sensitivity to tetracyclines, the drugs of preference in rickettsiosis treatment. "
01/01/1982 - " of the rickettsioses is based on the use of specific antibiotics, including the tetracyclines and chloramphenicol, but antibiotics should not be used routinely for prophylaxis. "

02/01/2018 - "Detection of causative agents of tick-borne rickettsioses in Western Siberia, Russia: identification of Rickettsia raoultii and Rickettsia sibirica DNA in clinical samples."
04/01/2017 - "To evaluate the epidemiology and clinical features of rickettsial disease in pediatric patients in Ghana, we screened blood samples from febrile children aged less than 15 years presenting to an outpatient department in Ghana's Ashanti Region for the presence of rickettsial DNA. "
09/22/2014 - "To evaluate the possible circulation of Rickettsia spp. in Comorian cattle, genomic DNA was extracted from 512 ticks collected either in the Union of the Comoros or from animals imported from Tanzania and subsequently tested for Rickettsia infection by quantitative PCR. "
08/01/2004 - "We used this "suicide" PCR with DNA from 103 skin biopsy specimens from patients who definitely had a rickettiosis, 109 skin biopsy specimens from patients who possibly had a rickettsiosis, and 50 skin biopsy specimens from patients with nonrickettsial diseases. "
01/01/2020 - "Because replication of SFGR and TGR in endothelial cells results in very low bacteremia, optimal sensitivity of qPCR for these rickettsioses will require use of larger volumes of input DNA, which could be achieved by improved extraction of DNA from blood and/or extraction of DNA from a larger initial volume of blood."

12/01/2011 - "White blood cell count, erythrocyte sedimentation rate, C-reactive protein, and liver function tests were not helpful in differentiating rickettsioses from CGF. "
01/01/2017 - "In this case, both the C-reactive protein and white blood cell count levels were lower than the ranges of these parameters for patients diagnosed with rickettsiosis. "
04/10/2015 - "The most common clinical findings of dogs with Rickettsia infection diagnosed by seroconversion and/or PCR were fever, myalgia, lameness, elevation of C-reactive protein, thrombocytopenia and hypoalbuminemia. "
05/12/2020 - "Although C-reactive protein (CRP) and procalcitonin (PCT) are widely used inflammatory markers for infectious diseases, their role and potential application for rickettsioses were rarely studied. "
02/01/2017 - "Multivariate analysis revealed the following six important factors for differentiating the rickettsial diseases and Q fever group from the dengue fever group: fever ≥8 days, alanine aminotransferase > aspartate aminotransferase, platelets >63,000/mL, C-reactive protein >31.9 mg/L, absence of bone pain, and absence of a bleeding syndrome. "

04/01/1953 - "Q FEVER, rickettsial disease, can be cured by terramycin."

07/01/1982 - "Chloramphenicol is useful in the treatment of invasive Haemophilus influenzae infections resistant to ampicillin, in selected anaerobic and ocular infections, and for rickettsioses in patients under the age of eight years. "

01/01/2018 - "Amoxicillin is the local standard treatment for AFI, but would not be effective for Bartonella spp. infections, SFG rickettsiosis, Q fever infections, or the viral infections. "

02/01/2010 - "As antimicrobials effective for rickettsial disease are usually not included in empirical therapy of nonspecific febrile illnesses, treatment of rickettsial disease is not provided unless they are suspected. "
01/15/2002 - "Until now, there has not been a gold-standard therapy for this rickettsial disease in children. "
11/01/2020 - "Early clinical suspicion, timely diagnosis followed by institution of specific antimicrobial therapy shortens the course of the disease, lowers the risk of complications and reduces morbidity and mortality due to rickettsial diseases. "
05/13/2016 - "Tickborne rickettsial diseases continue to cause severe illness and death in otherwise healthy adults and children, despite the availability of low-cost, effective antibacterial therapy. "
10/01/2013 - "Although the growing number of rickettsial species may be daunting to the clinician, recognition of the patterns of rickettsial disease will ensure prompt and effective therapy."

07/01/1963 - "[REVIEW OF THE ACTION OF CHEMOTHERAPY IN THE RICKETTSIOSES]."
01/01/1957 - "Chemotherapy of viral and rickettsial diseases."
04/01/1951 - "[Progress in the chemotherapy of rickettsial diseases]."
01/01/1951 - "[Investigations on chemotherapy of experimental rickettsial diseases]."
11/01/1949 - "Chemotherapy in viral and rickettsial disease."

09/01/1998 - "[Rickettsioses: their chemoprophylaxis and chemotherapy]."
01/01/2011 - "[Present stage of chemotherapy and chemoprophylaxis of rickettsiosis and Q fever]."
08/01/2015 - "The pretravel medical consultation includes immunizations, malaria chemoprophylaxis, self-treatment for traveler's diarrhea, and advice on the prevention of a myriad of other infectious causes including dengue, chikungunya, rickettsiosis, leptospirosis, schistosomiasis, and strongyloidiasis. "
11/01/2013 - "Doxycycline chemoprophylaxis against malaria in travelers to sub-Saharan Africa also protects against rickettsioses; thus, empirical treatment strategies for febrile illness for travelers and residents in sub-Saharan Africa may require reevaluation. "
01/01/2011 - "The analysis of the published experimental and clinical data on chemoprophylaxis and chemotherapy of rickettsiosis and Q fever confirmed the preserved role of doxycycline, the main drug of choice in the treatment of the diseases, then followed chloramphenicol. "

05/01/1991 - "Such surveillance data would promote awareness of rickettsioses among local physicians and increase the probability that individual patients with rickettsioses would be identified promptly and receive appropriate therapy early in the course of their illness."

01/01/1983 - "Excluding iatrogenic arteritis, particularly after vascular surgery, and some vasculitis in which an infectious agent may play a role, only the classical but now rare causes are described: rickettsial disease, syphilis and typhoid. "