Riboflavin (Vitamin B2)

Nutritional factor found in milk, eggs, malted barley, liver, kidney, heart, and leafy vegetables. The richest natural source is yeast. It occurs in the free form only in the retina of the eye, in whey, and in urine; its principal forms in tissues and cells are as FLAVIN MONONUCLEOTIDE and FLAVIN-ADENINE DINUCLEOTIDE.

Also Known As:

Networked: 1345 relevant articles (90 outcomes, 171 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Hafezi, Farhad: 12 articles (11/2015 - 10/2006)
2.	Wollensak, Gregor: 11 articles (08/2010 - 05/2003)
3.	Seiler, Theo: 10 articles (10/2015 - 05/2003)
4.	Spoerl, Eberhard: 9 articles (01/2015 - 05/2003)
5.	Mazzotta, Cosimo: 9 articles (01/2014 - 05/2006)
6.	Kymionis, George D: 9 articles (05/2013 - 11/2007)
7.	Powers, Hilary J: 9 articles (06/2011 - 06/2003)
8.	Caporossi, Aldo: 8 articles (01/2015 - 05/2006)
9.	Baiocchi, Stefano: 8 articles (05/2012 - 05/2006)
10.	McNulty, Helene: 7 articles (03/2015 - 10/2002)

Related Diseases

1.	Keratoconus 01/01/2015 - "Riboflavin/UVA corneal cross-linking is considered a safe procedure and is extremely effective in halting keratoconus' progression. " 03/01/2012 - "The study demonstrated significant and rapid functional improvement in pediatric patients younger than 18 years with progressive keratoconus, undergoing riboflavin-UVA–induced cross-linking. " 01/01/2012 - "Application of transepithelial CXL using riboflavin with substances added to enhance epithelial permeability was safe, seemed to be moderately effective in keratoconic eyes with ultrathin corneas, and applications of the procedure could be extended to patients with advanced keratoconus." 01/01/2014 - ""Epithelium-on" and "epithelium-off" CXL using hypotonic 0.5% riboflavin were equally safe and effective in stabilization of keratoconus. " 10/01/2010 - "Partial topography-guided PRK followed by riboflavin/UVA CXL is a safe and effective therapy that halts the progression of keratoectasia and reduces the spherocylindrical refraction and aberrations to improve the visual function of patients with progressive keratoconus. "
2.	Migraine Disorders (Migraine) 02/01/1998 - "We found in a previous open study that high-dose riboflavin was effective in migraine prophylaxis. " 05/01/2014 - "RCT studies in adult confirmed that riboflavin is safe and probably effective in migraine prophylaxis, based on level B evidence. " 03/01/2014 - "Is riboflavin, an alternative to traditional pharmacologic agents, effective and safe for prevention of migraine in children? " 11/01/2008 - "This is the first study to evaluate the efficacy of riboflavin for migraine prophylaxis in children. " 07/01/2004 - "The aim of this study was to investigate the efficacy of riboflavin for the prevention of migraine. "
3.	Keratitis 08/01/2008 - "Riboflavin/UVA was effective against SA, SE, PA, MRSA, MDRPA, and DRSP, but was ineffective on CA and has the potential for use in treatment of microbial keratitis in the future." 08/01/2008 - "Antimicrobial efficacy of riboflavin/UVA combination (365 nm) in vitro for bacterial and fungal isolates: a potential new treatment for infectious keratitis." 02/01/2012 - "To evaluate the efficacy of corneal cross-linking (CXL) (riboflavin-UV-A) as a simple therapy in Fusarium keratitis. " 02/01/2010 - "To evaluate the antibacterial efficacy of photo-activated riboflavin using Ultraviolet A (UVA) on three bacterial strains commonly detected in keratitis. " 07/01/2015 - "Riboflavin-UVA photodynamic inactivation is a potential treatment alternative in therapy resistant infectious keratitis. "
4.	Headache (Headaches) 07/01/2004 - "We could demonstrate a significant reduction of headache frequency following riboflavin treatment. " 10/01/2008 - "There are no trials to indicate the safety or efficacy of riboflavin or feverfew for pediatric headache." 12/01/2010 - "However, a significant difference in reduction of mean frequency of headaches with a tension-type phenotype was found in favour of the riboflavin treatment (P = 0.04). " 11/01/2008 - "A 50% or greater reduction in headaches was seen in 14/21 patients in the placebo group and 12/27 patients in the riboflavin group (not significant P = .125). " 02/01/1998 - "Using an intention-to-treat analysis, riboflavin was superior to placebo in reducing attack frequency (p = 0.005) and headache days (p = 0.012). "
5.	Anemia 01/01/2014 - "The aim of the study was to determine the relationship between riboflavin intake and the risk of anemia in a Chinese cohort. " 01/01/2014 - "Cross-sectional population studies show a relationship between riboflavin intake and anemia but prospective population studies are limited. " 01/01/2014 - "Inadequate riboflavin intake and anemia risk in a Chinese population: five-year follow up of the Jiangsu Nutrition Study." 01/01/2014 - "Inadequate riboflavin intake is common and increases the risk of anemia in Chinese adults. " 01/01/2014 - "In the multivariate model, adjusting for demographic and lifestyle factors and dietary patterns, the relative risk and 95% confidence interval for anemia at follow-up, across quartiles of riboflavin intake were: 1, 0.82(0.54-1.23), 0.56(0.34-0.93), 0.52(0.28-0.98) (p for trend 0.021). "

Related Drugs and Biologics

1.	Collagen
2.	Magnesium
3.	Vitamins
4.	Ascorbic Acid (Vitamin C)
5.	coenzyme Q10 (CoQ10)
6.	Vitamin A (Retinol)
7.	Iron
8.	Niacin (Nicotinic Acid)
9.	Folic Acid (Vitamin M)
10.	Carotenoids (Carotene)

Related Therapies and Procedures

1.	Photorefractive Keratectomy
2.	Lasers (Laser)
3.	Drug Therapy (Chemotherapy)
4.	Chemoprevention
5.	Radial Keratotomy