Rhodamines

A family of 3,6-di(substituted-amino)-9-benzoate derivatives of xanthene that are used as dyes and as indicators for various metals; also used as fluorescent tracers in histochemistry.

Also Known As:

Networked: 311 relevant articles (3 outcomes, 23 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Choyke, Peter L: 14 articles (01/2015 - 11/2006)
2.	Kobayashi, Hisataka: 14 articles (01/2015 - 11/2006)
3.	Urano, Yasuteru: 8 articles (01/2015 - 11/2006)
4.	Hama, Yukihiro: 8 articles (08/2008 - 11/2006)
5.	Koyama, Yoshinori: 7 articles (11/2007 - 11/2006)
6.	Kosaka, Nobuyuki: 5 articles (11/2011 - 08/2008)
7.	Storm, Gert: 4 articles (02/2012 - 04/2011)
8.	Ogawa, Mikako: 4 articles (11/2011 - 08/2008)
9.	Kamiya, Mako: 3 articles (01/2015 - 03/2007)
10.	Lammers, Twan: 3 articles (02/2012 - 04/2011)

Related Diseases

1.	Neoplasms (Cancer) 03/01/2011 - "Microscopic studies revealed that the vascular constrained, rhodamine-labeled α(v)β(3)-GNBs homed specifically to immature neovasculature (PECAM(+), Tie-2(-)) along the immediate tumor periphery, but not to nearby mature microvasculature (PECAM(+), Tie-2(+)). " 01/01/2015 - "We previously developed γ-glutamyl hydroxymethyl rhodamine green (gGlu-HMRG) as a tool to detect viable cancer cells, based on the fact that the enzyme γ-glutamyltranspeptidase (GGT) is overexpressed on membranes of various cancer cells, but is not expressed in normal tissue. " 06/01/2013 - "A t(½) of 39.3 h and 69.7 h in cargo release in serum was observed before and after PEG decoration, and incorporation of SV119 led to selective delivery of rhodamine-labeled spherulites to PC-3 tumor cells. " 03/01/2013 - "For example, gGlu-HMRG, a novel spirocyclized rhodamine-based fluorescence probe for γ-glutamyltranspeptidase(GGT), which is well-known to be upregulated in various cancer cells, was successfully developed. " 11/23/2011 - "We synthesized a rapidly activatable, cancer-selective fluorescence imaging probe, γ-glutamyl hydroxymethyl rhodamine green (gGlu-HMRG), with intramolecular spirocyclic caging for complete quenching. "
2.	Hepatolenticular Degeneration (Wilson's Disease) 12/01/2004 - "Investigation regarding Wilson's disease gave positive results, since the use of rhodamine staining, which is specific to detect the presence of copper in tissues, resulted in red-brown grains at light microscopy. "
3.	Tuberculosis (Tuberculoses) 04/01/2003 - "The aim of this study was to compare auramin-rhodamine (A-R) and Erlich-Ziehl-Neelsen (EZN) staining techniques for the diagnosis of tuberculosis. " 09/01/2014 - "Here, we aimed to assess the feasibility of anti-ESAT-6 monoclonal antibody (mAb) coupling with IR783 and rhodamine fluorescent probe in the detection of ESAT-6 expression in tuberculosis tissue of mice using near-infrared fluorescence imaging. " 05/01/2007 - "The membrane potential of M.tuberculosis was determined by flow-cytometry with Rhodamine to investigate the mechanism of PZA activity. " 07/01/2014 - "To overcome the cumbersome process involved in collection and processing of the sputum specimen, the time consumed for reporting of sputum by Ziehl Neelsen (ZN) method and to introduce a routine screening test in suspected, symptomless tuberculosis patients, the present study was designed using saliva as diagnostic medium and Auramine Rhodamine (AR) as staining method. " 07/01/2003 - "A total of 300 sputum samples obtained from suspected cases of Tuberculosis were collected and were subjected to staining by rhodamine auramine at 37 degrees C and also at room temperature (conventional method). "
4.	Breast Neoplasms (Breast Cancer) 06/07/2014 - "Visible light excitable ON fluorescence and naked eye detection of Cu²⁺ via hydrolysis of rhodamine-thiophene conjugate: human breast cancer cell (MCF7) imaging studies." 01/01/2009 - "Microscopy and flow cytometry studies show higher uptake in MDA-MB-231 breast cancer cells when exposed to rhodamine-loaded nanoparticles than to rhodamine in solution." 01/01/2011 - "In order to follow their release and uptake in breast tumor cells in real time, cell-derived exosomes were tagged with green fluorescent protein (GFP)-CD63 while human serum exosomes were rhodamine isothiocynate-labeled. " 01/01/2009 - "Rhodamine-loaded poly(lactic-co-glycolic acid) nanoparticles for investigation of in vitro interactions with breast cancer cells." 07/01/2008 - "To demonstrate the versatility of our experimental approach, we use rhodamine 123-labeled mitochondria in breast cancer cells (Hs578T), verified using differential interference contrast (DIC) and fluorescence (confocal and two-photon) microscopy, as a model system. "
5.	Ovarian Neoplasms (Ovarian Cancer) 10/01/2011 - "A mouse xenograft model of ovarian cancer with an activatable imaging probe based on rhodamine green was used to test the device. " 08/01/2008 - "Herein, we demonstrate that the rhodamine-fluorophore, TAMRA, is the most robust of the 4 common rhodamine fluorophores for in vivo optical imaging of ovarian cancer metastases to the peritoneum." 11/01/2006 - "While fluorescein demonstrated the highest signal outside the cell, among the four fluorophores, internalized Av-rhodamine green emitted the most light from SHIN3 ovarian cancer cells both in vitro and in vivo. " 11/01/2007 - "The D-galactose receptor on ovarian cancer cells has been used to target self-quenched avidin-rhodamineX conjugates in which the avidin component binds to D-galactose receptor and the rhodamines are optically activated by dequenching only after cellular internalization. " 03/01/2014 - "Galactosyl serum albumin-rhodamine green (GSA-RhodG), which bound to the D-galactose receptor and was internalized thereafter, was administered intraperitoneally to peritoneal ovarian cancer-bearing mice with various degrees of bloody ascites. "

Related Drugs and Biologics

1.	Folic Acid (Vitamin M)
2.	Copper
3.	Argon
4.	Hematoporphyrins
5.	Benzophenoneidum (Auramine O)
6.	Fluorescent Dyes (Fluorescent Probes)
7.	Avidin
8.	Fluorescein (Funduscein)
9.	Liposomes (Liposome)
10.	Serum Albumin

Related Therapies and Procedures

1.	Lasers (Laser)
2.	Intraperitoneal Injections
3.	Microspheres (Microsphere)
4.	Heterologous Transplantation (Xenotransplantation)
5.	Dye Lasers