Rhinosporidiosis

Chronic, localized granulomatous infection of mucocutaneous tissues, especially the NOSE, and characterized by HYPERPLASIA and the development of POLYPS. It is found in humans and other animals and is caused by the mesomycetozoean organism RHINOSPORIDIUM SEEBERI.

Also Known As:

Networked: 48 relevant articles (3 outcomes, 3 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Infections
2.	Polyps
3.	Nasal Obstruction
4.	Cysts
5.	Inverted Papilloma

Experts

1.	Arseculeratne, S N: 5 articles (10/2011 - 07/2002)
2.	Eriyagama, N B: 3 articles (10/2011 - 01/2005)
3.	Atapattu, D N: 2 articles (04/2006 - 01/2005)
4.	Abraham, Zephania Saitabau: 1 article (06/2022)
5.	Kahinga, Aveline Aloyce: 1 article (06/2022)
6.	Zerd, Francis: 1 article (06/2022)
7.	Doddawad, Vidya G: 1 article (03/2022)
8.	S, Shivananda: 1 article (03/2022)
9.	Singh, Ranbir: 1 article (03/2022)
10.	Benito-León, Julián: 1 article (01/2021)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Rhinosporidiosis:

1.	DapsoneFDA Link 06/01/1981 - "Our experience with this case suggest that Dapsone may be a successful drug in cutaneous rhinosporidiosis." 06/01/1981 - "Disseminated cutaneous rhinosporidiosis treated with dapsone." 02/01/1979 - "Clinical trial of diaminodiphenylsulfone (DDS) in nasal and nasopharyngeal rhinosporidiosis." 01/01/2014 - "Comments on 'novel multidrug therapy for disseminated rhinosporidiosis, refractory to dapsone - case report'." 07/01/2013 - "Novel multidrug therapy for disseminated rhinosporidiosis, refractory to dapsone – case report."
2.	AntigensIBA 09/01/1982 - "Detection of circulating antigen in patients with rhinosporidiosis." 09/01/1982 - "A study was undertaken to demonstrate antibodies or antigen in the serum or plasma of 69 patients with rhinosporidiosis. "
3.	AntibodiesIBA 09/01/1982 - "A study was undertaken to demonstrate antibodies or antigen in the serum or plasma of 69 patients with rhinosporidiosis. "
4.	Ketoconazole (Nizoral)FDA LinkGeneric 01/01/2017 - "A multidrug regimen of systemic cycloserine, ketoconazole, and dapsone was administered to treat disseminated rhinosporidiosis, in addition to antiretroviral therapy. " 07/01/2013 - "Here we report a case of disseminated rhinosporidiosis in an immunocompromised individual on antiretroviral drugs, non-responsive to Dapsone and therefore treated with a multidrug therapy of Cycloserine, Dapsone and Ketoconazole with good response." 01/01/2021 - "We herein report a case of an immunocompetent person with primary disseminated dermato-pulmonary rhinosporidiosis, which created significant diagnostic dilemma at the beginning, got complicated due to dapsone-induced direct anti-globulin test-positive autoimmune hemolytic anemia, and finally responded to prolonged multidrug therapy with liposomal amphotericin B, ketoconazole and cycloserine. "
5.	Cycloserine (Seromycin)FDA Link 01/01/2017 - "A multidrug regimen of systemic cycloserine, ketoconazole, and dapsone was administered to treat disseminated rhinosporidiosis, in addition to antiretroviral therapy. " 07/01/2013 - "Here we report a case of disseminated rhinosporidiosis in an immunocompromised individual on antiretroviral drugs, non-responsive to Dapsone and therefore treated with a multidrug therapy of Cycloserine, Dapsone and Ketoconazole with good response." 01/01/2021 - "We herein report a case of an immunocompetent person with primary disseminated dermato-pulmonary rhinosporidiosis, which created significant diagnostic dilemma at the beginning, got complicated due to dapsone-induced direct anti-globulin test-positive autoimmune hemolytic anemia, and finally responded to prolonged multidrug therapy with liposomal amphotericin B, ketoconazole and cycloserine. "
6.	Amphotericin B (Amphotericin)FDA LinkGeneric 01/01/1986 - "This paper reports a case of rhinosporidiosis which presented with widespread subcutaneous nodular lesions which failed to respond to surgical excision or to intravenous amphotericin B. " 06/01/2007 - "Second case presented with recurrence of rhinosporidiosis even after nine times surgical intervention with systemic Amphotericin-B. " 07/01/2016 - "A patient with disseminated rhinosporidiosis did not respond to conventional therapy with dapsone and surgical excision, and treatment with amphotericin B also proved futile. "
7.	Fluorodeoxyglucose F18 (Fludeoxyglucose F 18)FDA Link 10/01/2020 - "18F-FDG PET/MRI of Rhinosporidiosis of the Upper Airways."
8.	Fluconazole (Zonal)FDA LinkGeneric 06/01/2022 - "Nasal rhinosporidiosis masquerading as pyogenic granuloma in a pediatric patient at a Zonal Referral Hospital in Central Tanzania: Case report."
9.	Tuberculin (PPD)IBA 01/01/2010 - "Mantoux positivity to PPD was found in 65% of normal Sri Lankans, by only 35% of patients with rhinosporidiosis. "
10.	Silver NitrateIBA 04/01/2006 - "Anti-rhinosporidial antiseptics that could be used in surgery on rhinosporidial patients include povidone-iodine in nasal packs for nasal and naso-pharyngeal surgery, chlorhexidine and cetrimide-chlorhexidine on the skin, while povidone-iodine and silver nitrate could have application in ocular rhinosporidiosis."

Therapies and Procedures

1.	Therapeutics 01/01/2014 - "Disseminated rhinosporidiosis can be successfully treated with multidrug therapy. " 01/01/2014 - "Comments on 'novel multidrug therapy for disseminated rhinosporidiosis, refractory to dapsone - case report'." 07/01/2013 - "Novel multidrug therapy for disseminated rhinosporidiosis, refractory to dapsone – case report." 05/01/2011 - "Disseminated cutaneous with nasopharyngeal rhinosporidiosis: Light microscopy changes following dapsone therapy." 12/01/1997 - "Morphological findings in serial nasal mucosal biopsies from three cases of rhinosporidiosis on dapsone therapy were compared with biopsies from 33 patients taken before dapsone or surgical treatment was initiated. "
2.	Osteotomy 10/01/2018 - "Through this study we hope to prove the efficacy of Le Fort I osteotomy in the definitive management of nasopharyngeal rhinosporidiosis." 10/01/2018 - "At our center, excision of the lesion with a Le Fort I osteotomy is carried out in patients (1) in whom two or more previous attempts at excision of biopsy-proven rhinosporidiosis arising from the nasal mucosa was carried out or (2) in whom the rhinosporidiosis arises from the nasophayrngeal mucosa and/or extranasal sites. " 10/01/2018 - "Long-term use of Le Fort I osteotomy for the management of nasopharyngeal rhinosporidiosis: A case series."
3.	Dacryocystorhinostomy 07/01/2022 - "Five patients (45.4%) with lacrimal sac rhinosporidiosis underwent dacryocystectomy and modified dacryocystorhinostomy (DCR). " 01/01/2019 - "To describe the outcome of external dacryocystorhinostomy (DCR) as a suitable alternative to dacryocystectomy (DCT) in cases of isolated lacrimal sac rhinosporidiosis. " 01/01/2019 - "External dacryocystorhinostomy for isolated lacrimal sac rhinosporidiosis - A suitable alternative to dacryocystectomy." 02/01/2014 - "Lacrimal sac rhinosporidiosis: clinical profile and surgical management by modified dacryocystorhinostomy." 07/01/2019 - "A variety of surgical procedures have been used to treat rhinosporidiosis of lacrimal sac like dacryocystorhinostomy, Dacryocystectomy, lateral rhinotomy and local lesion excision with a success rate varying from 28.5% to 92.3%. "
4.	Cautery 12/02/2020 - "Histological examination is thus necessary for the definitive diagnosis of rhinosporidiosis, and the first line of treatment is usually total surgical excision and electro-cauterization of the polyp base. " 09/01/2018 - "Surgical excision of all lesions along with cauterization of the base and long-term dapsone therapy is the current standard of care for multicentric rhinosporidiosis." 05/01/2015 - "We report a case of Rhinosporidiosis at the lateral pharyngeal wall which is a very rare site for Rhinosporidiosis to occur; was treated by diathermy excision of the mass and cauterization of the base and oral Dapsone to prevent recurrence of the disease. "
5.	Lasers (Laser) 10/01/2005 - "KTP-532 laser in the management of rhinosporidiosis." 03/01/2022 - "Because chemotherapy has not been proven to be effective, Laser-assisted endoscopic excision, in combination with Dapsone is the recommended treatment for Rhinosporidiosis. "