HOME PRODUCTS SERVICES COMPANY CONTACT FAQ

Rheumatic Fever (Acute Articular Rheumatism)

Subscribe to New Research on Rheumatic Fever

A febrile disease occurring as a delayed sequela of infections with STREPTOCOCCUS PYOGENES. It is characterized by multiple focal inflammatory lesions of the connective tissue structures, such as the heart, blood vessels, and joints (POLYARTHRITIS) and brain, and by the presence of ASCHOFF BODIES in the myocardium and skin.

Also Known As:

Acute Articular Rheumatism; Arthritis, Acute Rheumatic; Inflammatory Rheumatism; Polyarthritis Rheumatica; Rheumatic Arthritis; Rheumatism, Acute Articular; Acute Articular Rheumatisms; Acute Rheumatic Arthritides; Acute Rheumatic Arthritis; Acute Rheumatic Fevers; Arthritides, Acute Rheumatic; Articular Rheumatism, Acute; Articular Rheumatisms, Acute; Fever, Acute Rheumatic; Fever, Rheumatic; Fevers, Acute Rheumatic; Fevers, Rheumatic; Polyarthritis Rheumaticas; Rheumatic Arthritides, Acute; Rheumatic Arthritis, Acute; Rheumatic Fever, Acute; Rheumatic Fevers; Rheumatic Fevers, Acute; Rheumatisms, Acute Articular; Acute Rheumatic Fever; Arthritis, Rheumatic, Acute; Rheumatism, Articular, Acute

Networked: 1745 relevant articles (36 outcomes, 171 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Infection
2.	Pharyngitis (Sore Throat)
3.	Rheumatic Heart Disease (Rheumatic Heart Diseases)
4.	Myocarditis (Carditis)
5.	Glomerulonephritis

Experts

1.	Chhatwal, Gursharan S: 7 articles (01/2012 - 06/2003)
2.	Kalil, Jorge: 7 articles (06/2008 - 05/2004)
3.	Guilherme, Luiza: 7 articles (06/2008 - 05/2004)
4.	Shulman, Stanford T: 7 articles (01/2008 - 01/2003)
5.	Tani, Lloyd Y: 7 articles (01/2008 - 12/2002)
6.	Cunningham, Madeleine W: 5 articles (07/2014 - 01/2002)
7.	Rohde, Manfred: 5 articles (12/2009 - 06/2003)
8.	Dinkla, Katrin: 5 articles (12/2009 - 06/2003)
9.	Hill, Harry R: 5 articles (03/2008 - 11/2002)
10.	Newburger, Jane W: 5 articles (01/2008 - 06/2005)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Rheumatic Fever:

1.	Penicillins (Penicillin)FDA Link 02/04/1988 - "Penicillin and the marked decrease in morbidity and mortality from rheumatic fever in the United States." 03/01/1987 - "Regular monthly parenteral penicillin was found to be effective in reducing recurrence of rheumatic fever and maintaining good health in these children." 03/01/2003 - "Intramuscular penicillin is more effective than oral penicillin in secondary prevention of rheumatic fever--a systematic review." 08/02/2013 - "The aim of the study was to compare utilisation of the New Zealand guidelines for the diagnosis of acute rheumatic fever (ARF) compared to the American Heart Association Jones criteria in a cohort of children Retrospective review of 79 consecutive hospital diagnosed cases of ARF referred for secondary penicillin prophylaxis. " 12/01/2003 - "The results of this study suggest that penicillin values may be inadequate for prevention of rheumatic fever by Week 3 of administration in a majority of children."
2.	Penicillin G Benzathine (LPG)FDA Link 03/01/2015 - "Secondary prophylaxis with monthly injection of benzathine penicillin is effective in preventing recurrence of acute rheumatic fever and worsening of RHD, but adherence rates are poor in Uganda. " 03/01/2000 - "Benzathine penicillin G (BPG) is effective for secondary prophylaxis of rheumatic fever (RF). " 12/01/2004 - "(4) Comparative trials done in the 1950s showed that benzathine benzylpenicillin helped prevent acute rheumatic fever, reducing the risk by about 75%. " 08/01/2004 - "Previous in vivo studies using sister chromatid exchange (SCE) frequency and comet assay, had showed that long-term administration of benzathine penicillin G may cause some degree of DNA damage in children with rheumatic fever. " 06/01/2001 - "Thirty-five children with confirmed rheumatic fever under benzathine penicillin prophylaxis were enrolled in the study and 35 healthy children with similar ages and socioeconomic backgrounds served as controls. "
3.	Anti-Bacterial Agents (Antibiotics)IBA 01/01/2013 - "Several studies found antibiotics reduced acute rheumatic fever by more than two-thirds within one month (risk ratio (RR) 0.27; 95% confidence interval (CI) 0.12 to 0.60). " 01/01/2006 - "Several studies found antibiotics reduced acute rheumatic fever by more than two thirds (relative risk (RR) 0.22; 95% CI 0.02 to 2.08). " 01/01/2004 - "Several studies found that antibiotics reduced acute rheumatic fever, to less than one third (odds ratio (OR) = 0.30; 95% confidence interval (CI) = 0.20 to 0.45). " 01/01/2000 - "Several studies found benefit from antibiotics for acute rheumatic fever, which reduced this complication to less than one third (OR = 0.30; 95% CI = 0.20-0.45). " 01/01/2000 - "Several studies found benefit from antibiotics for acute rheumatic fever, which reduced this complication to less than one third (OR = 0.30; 95% CI = 0.20-0.45). "
4.	AntigensIBA 07/15/2003 - "Rheumatic fever has become uncommon in the United States while rapid diagnostic test technology for streptococcal antigens has improved. " 10/01/1992 - "We report the results of research on human leukocyte allo-antigen (HLA) and rheumatic fever (RF), the first published study to be carried out among Turkish children with RF. " 09/01/1990 - "Immunogenetic study of the response to streptococcal carbohydrate antigen of the cell wall in rheumatic fever." 07/01/1989 - "Our study examines the distribution of cells bearing these "rheumatic" antigens in 23 subjects with rheumatic fever/RHD of Maori, Polynesian and Caucasian ancestry and 182 members of their families (rheumatic fever/RHD families) as well as in 46 members of families in which no member had been demonstrated to have had rheumatic fever/RHD (control families). " 10/01/1988 - "This assumption needs a detailed study in view of the hypothesis about the important role of cross-reactive antigens of group A streptococci in generating autoimmune process during rheumatic fever and other streptococcal diseases. "
5.	Antistreptolysin (Antistreptolysin O)IBA 05/01/1957 - "Further studies on rheumatic fever epidemiology; comparative incidence of rheumatic fever, streptococcal carriers, and antistreptolysin titers in the tropics and in Mexico City." 05/01/1954 - "[Serological research in chronic inflammatory rheumatism; study of antistreptolysin O]." 08/01/1946 - "Immunologic studies in rheumatic fever; antistreptolysin patterns in rheumatic children." 03/01/2012 - "High antistreptolysin-O titres were found in 58.3%, and family history of rheumatic fever, in 14.5%. " 01/02/2012 - "Over diagnosis of acute rheumatic fever (ARF) based on a raised antistreptolysin O titer (ASOT) is not uncommon in endemic areas. "
6.	Adrenocorticotropic Hormone (ACTH)FDA Link 11/01/1949 - "REPORT adrenocorticotrophic hormone produces definite improvement in rheumatic fever." 02/01/1952 - "[Study of the effect of the pituitary adrenocorticotrophic hormone (ACTH) on the clinical picture, metabolic and hormonal state and histological lesions of rheumatic fever]." 11/01/1949 - "Immunologic and biochemical studies in infants and children with special reference to rheumatic fever; response to pituitary adrenocorticotropic hormone." 05/22/1958 - "[Treatment of rheumatic fever with ACTH]." 05/06/1956 - "[ACTH therapy in rheumatic fever]."
7.	Immunoglobulins (Immunoglobulin)IBA 01/23/2001 - "Intravenous immunoglobulin in acute rheumatic fever: a randomized controlled trial." 07/01/1972 - "Immunological remarks on rheumatic fever in children with reference to heart-reactive serum factors, immunoglobulins and 1C -globulin levels." 07/01/1968 - "Immunoglobulins in rheumatic fever." 09/01/1967 - "[The immunoglobulins in rheumatic fever in childhood]." 02/01/1987 - "Serum levels of immunoglobulins in acute rheumatic fever and rheumatic heart disease."
8.	Immunoglobulin A (IgA)IBA 01/01/1987 - "A combination of two variables (artificial subcutaneous nodules and IgA) had a sensitivity of 84% and a specificity of 100% for rheumatic fever." 01/01/1987 - "A combination of three variables (artificial subcutaneous nodules, IgA, and C3) had a sensitivity of 87% and a specificity of 100% for rheumatic fever. " 07/01/1982 - "However, its presence in rheumatic fever patients did not correlate directly with amounts of serum IgA present (r = 0.0507). " 07/01/1982 - "Serum immunoglobulin A and antibody to M-associated protein in patients with acute glomerulonephritis or rheumatic fever." 06/01/1982 - "Skin infections and immunoglobulin A in serum, sweat, and saliva of patients recovered from poststreptococcal acute glomerulonephritis or acute rheumatic fever and their siblings."
9.	VaccinesIBA 03/01/1978 - "Prevention of rheumatic fever, with or without vaccines." 03/15/1986 - "These studies hold promise for the development of safe and effective vaccines against group A streptococci, especially against the strains giving rise to rheumatic fever and rheumatic heart disease." 06/15/2010 - "The findings underscore the potential health and economic burden of acute rheumatic fever and RHD and support the need for more effective measures of prevention, which may include safe, effective, and affordable vaccines to prevent the streptococcal infections that trigger the disease." 01/01/2006 - "Advances in potential M-protein peptide-based vaccines for preventing rheumatic fever and rheumatic heart disease." 03/01/1999 - "Also discussed are future strategies for the development of broadly protective vaccines, and their potential impact on the incidence of streptococcal infections, and acute rheumatic fever."
10.	Erythromycin (Erycette)FDA LinkGeneric 01/01/1957 - "A trial of erythromycin in rheumatic fever prophylaxis." 11/08/2013 - "A 9-year-old girl, with rheumatic heart disease, on secondary prophylaxis with erythromycin 250 mg BD, presented with acute rheumatic fever. " 01/01/1968 - "Occurrence and erythromycin susceptibility of penicillin-resistant Viridans streptococci in rheumatic fever patients on oral penicillin prophylaxis." 10/01/1977 - "Erythromycin may be used as prophylactic therapy for subacute bacterial endocarditis and for recurrence of acute rheumatic fever in patients who are allergic to penicillin. " 07/01/1959 - "The prophylaxis of streptococcal infections in patients with rheumatic fever; a comparison between sulfadiazine and erythromycin."

Therapies and Procedures

1.	Injections 01/01/1983 - "Rheumatic fever prophylaxis in developing countries--why earlier injections needed." 03/01/2008 - "In similar cases with recurrences of either arthritis or carditis, instead of long-term corticosteroid therapy, we suggest a regimen of BPG prophylaxis every two weeks rather than every three weeks or monthly BPG injections because of the superiority of the every two weeks schedule in the adequate control of rheumatic fever recurrences, as shown in some previous studies." 01/01/1960 - "[The treatment of acute inflammatory rheumatism (Bouillaud's disease and Fiessinger-Leroy-Reiter syndrome) by diacetylpyrocatecholcarboxylic acid and its injectable derivative]." 09/01/2009 - "The efficacy of injectable penicillin, in high rheumatic fever incidence military environments is indisputable. " 05/29/2015 - "Long-term benzathine penicillin G (BPG) injections are effective in preventing recurrent acute rheumatic fever attacks and are recommended to be administered every 3-4 weeks for 10 years or until age 21 years to children who receive a diagnosis of acute rheumatic fever. "
2.	Chemoprevention 01/26/1956 - "Studies of bacterial throat flora during chemoprophylaxis of rheumatic fever." 01/01/1966 - "Chemoprevention of rheumatic fever." 10/10/1965 - "Chemoprophylaxis of relapse of rheumatic fever]." 11/01/1966 - "Rheumatic fever without clinical evidence of carditis: the necessity and efficacy of chemoprophylaxis." 12/01/1959 - "Chemoprophylaxis of infectious diseases, I. General considerations and application to streptococcal infections, rheumatic fever, glomerulonephritis and bacterial endocarditis."
3.	Baths 01/01/1984 - "The paper discusses the efficacy of rehabilitation of 108 patients with rheumatic fever with the use of radon baths, of them in 36 in conjunction with homologous immunoglobulin. "
4.	Nursing Care 03/30/1978 - "Nursing care study: rheumatic fever." 07/01/1977 - "Nursing care study (rheumatic fever)." 01/01/1949 - "Nursing care study on acute and convalescent rheumatic fever." 01/01/1978 - "Chosen example: nursing care in rheumatic fever]." 06/01/1952 - "The nursing care of children with acute rheumatic fever."
5.	Tonsillectomy 06/01/1990 - "No association between the disease and antecedents of tonsillectomy, rheumatic fever, educational level, place of residence, or marital status was found." 04/04/1970 - "Tonsillectomy after rheumatic fever." 12/16/1967 - "Tonsillectomy and rheumatic fever." 04/01/1967 - "[Effect of tonsillectomy on the frequency of recurrences of rheumatic fever]." 03/01/1966 - "["Slow" or "rapid" tonsillectomy in rheumatic fever of tonsillar origin, in childhood?]."