Rhabdomyolysis

07/01/1992 - "The aims of this study were to create an animal model of fatal rhabdomyolysis in rats by a glycerol injection into the leg muscle, and to elucidate some of the factors affecting mortality as a result of rhabdomyolysis formation. "
06/01/2015 - "Rhabdomyolysis was induced by intramuscular glycerol injection in rats. "
06/01/2015 - "Macrophage infiltration has been observed in rat kidneys after glycerol-induced rhabdomyolysis, but the role of macrophages in rhabdomyolysis-induced AKI remains unknown. "
08/06/2014 - "To investigate a potential protective role of the kinin B2 receptor in a glycerol-induced rhabdomyolysis mouse model. "
08/06/2014 - "Kinin B2 receptor does not exert renoprotective effects on mice with glycerol-induced rhabdomyolysis."

01/01/2014 - "We aimed to: i) assess the efficacy of CRRT in removing myoglobin; ii) investigate the influence of CRRT on mortality and kidney-related outcomes; and iii) evaluate the safety of CRRT for the treatment of people with rhabdomyolysis. "
06/01/2012 - "The present study investigates myoglobin-induced apoptosis in HK-2 cells (human renal proximal tubule cells) to discover some of the mechanisms involved in rhabdomyolysis related AKI. "
01/01/2011 - "No cases of rhabdomyolysis (the breakdown of muscle fibres resulting in the release of muscle fibre contents (myoglobin) into the bloodstream) occurred in 274 patients enrolled in three studies. "
05/01/2014 - "An extended two compartment model is proposed to describe the dynamics of myoglobin in rhabdomyolysis patients undergoing dialysis. "
05/01/2014 - "Kinetic modelling of haemodialysis removal of myoglobin in rhabdomyolysis patients."

01/01/2013 - "During a 6-year study period, we retrospectively analyzed the medical charts of patients, aged 18 years or younger, with a definite diagnosis of rhabdomyolysis and serum creatinine phosphokinase (CK) levels greater than 1000IU/L. "
11/01/2015 - "Kocher-Debré-Semelaigne syndrome with rhabdomyolysis and increased creatinine."
01/01/2014 - "Severe elevation of serum CK consistent with rhabdomyolysis was noted and an elevated creatinine indicated acute renal impairment. "
07/01/2013 - "From 2006 to 2011, we retrospectively analyzed 202 patients 65 years or younger with a definite diagnosis of rhabdomyolysis and serum creatinine phosphokinase levels greater than 1000 IU/L. "
02/01/2013 - "Initial creatinine is a better predictor of ARF due to rhabdomyolysis than UM. "

01/01/2000 - "Simvastatin was discontinued, and rhabdomyolysis improved rapidly with conservative care. "
06/01/2014 - "Two randomised controlled trials have found a higher risk of rhabdomyolysis in users of 80 mg versus 20 mg simvastatin, but there is very limited information about the risk associated with other doses. "
07/01/2015 - "Simvastatin-induced rhabdomyolysis also developed in one case. "
06/01/2014 - "These findings provide reassurance that the absolute risk of rhabdomyolysis in a general population of simvastatin users is very low. "
06/01/2014 - "Current users of 40 mg simvastatin daily were about five times as likely to develop rhabdomyolysis as those taking 20mg; the adjusted odds ratio was 5.3 (95% CI 1.9-15.0). "

10/01/2011 - "We present a case of rhabdomyolysis recognized in a 68-year-old man after elevation of liver enzymes following prolonged urologic surgery. "
10/01/2011 - "Rhabdomyolysis recognized after elevation of liver enzymes following prolonged urologic surgery with lateral decubitus position -A case report-."
02/01/2011 - "Liver enzymes, LDH and CPK remained normal in all patients except for one diabetic patient who developed rhabdomyolysis. "
12/01/2009 - "Muscular enzymes are usually normal or slightly elevated, except during episodes of rhabdomyolysis. "
11/01/2009 - "The diagnosis of rhabdomyolysis was made based on myalgia localized in the bilateral upper extremities (bilateral trapezius, deltoid, biceps brachii, and teres major muscles) on magnetic resonance imaging and increased levels of muscle-derived serum enzymes. "

01/15/2014 - "We report rhabdomyolysis in an elderly patient, in multitreatment with different potentially myotoxic medications, taking place seven months after atorvastatin discontinuation. "
02/01/2012 - "Acute rhabdomyolysis is a rare but recognized side effect of atorvastatin occurring within a few weeks of initiation. "
03/01/2011 - "Using 10 mg atorvastatin per day as the reference dose, the odds ratios of rhabdomyolysis were 3.8 (95% CI 2.3-6.6) for 40 mg/day atorvastatin dose equivalent and 11.3 (95% CI 6.4-20.4) for 80 mg/day atorvastatin dose equivalent. "
04/01/2007 - "A case of early-onset rhabdomyolysis in a patient treated with atorvastatin is described. "
01/01/2003 - "A few case studies have reported rhabdomyolysis when the pharmacokinetics of atorvastatin have been affected by interacting drugs. "

11/01/2015 - "Rhabdomyolysis (RB) is a syndrome characterised by decomposition of skeletal muscle that could be life threatening, so the identification of biomarkers of its severity could help us in its treatment. "
07/01/2014 - "The patient developed raised cardiac biomarkers without any obvious cardiac issues, a phenomenon that has been linked to rhabdomyolysis previously. "
03/01/2012 - "Laboratory markers used to diagnose both ER and rhabdomyolysis are very sensitive, but not very specific, and imperfectly distinguish "subclinical" or asymptomatic from severe, life-threatening illness. "
03/10/2005 - "Biochemical markers of rhabdomyolysis did not subside until after repeat hemodialysis and normalized after 2 months in conjunction with improved renal function. "
09/01/2009 - "Using a laboratory marker such as CK can aid diagnosis of rhabdomyolysis and identify adverse drug events."

11/01/2003 - "The efficacy of dantrolene sodium in controlling exertional rhabdomyolysis in the Thoroughbred racehorse."
06/01/2011 - "Dantrolene is a skeletal muscle relaxant used commonly in performance horses to prevent exertional rhabdomyolysis. "
11/01/2010 - "Dantrolene sodium is used to prevent exertional rhabdomyolysis in predisposed horses. "
06/01/1995 - "These results indicate that an acute episode of rhabdomyolysis is associated with elevation in [Ca2+]i in skeletal muscles, and that dantrolene might be of benefit in treating this disease."
06/01/1988 - "The delay in making the diagnosis of acute rhabdomyolysis may have contributed to the outcome as the use of dantrolene may be of benefit in such patients."

07/01/2013 - "This study had three components: (a) resequencing the SLCO1B1 gene in 122 patients who developed rhabdomyolysis while on cerivastatin; (b) functional evaluation of the identified SLCO1B1 nonsynonymous variants and haplotypes in in-vitro HEK293/FRT cells stably transfected with pcDNA5/FRT empty vector, SLCO1B1 reference, variants, and haplotypes; and (c) in-vitro screening of 15 drugs commonly used among the rhabdomyolysis cases for inhibition of OATP1B1-mediated uptake of cerivastatin in HEK293/FRT cells stably transfected with reference SLCO1B1. "
04/17/2006 - "For statins other than cerivastatin, the incidence of rhabdomyolysis in 2 cohort studies was 3.4 (1.6 to 6.5) per 100,000 person-years, an estimate supported by data from 20 randomized controlled trials. "
12/01/2004 - "The company continued to conduct safety studies, some of them inadequately designed to assess the risk of rhabdomyolysis, until cerivastatin was removed from the market in August 2001. "
07/01/2013 - "Reduced function of OATP1B1 related to genetic variation and drug-drug interactions likely contributed to cerivastatin-induced rhabdomyolysis. "
07/01/2013 - "We investigated whether patients exhibiting rhabdomyolysis who were taking cerivastatin possess functional genetic variants in SLCO1B1 and whether they were on concomitant medications that inhibit OATP1B1, resulting in accumulation of cerivastatin. "

01/01/2009 - "Statins are effective in lowering cholesterol levels, but cause fatal rhabdomyolysis in susceptible individuals. "
12/01/2013 - "[Massive rhabdomyolysis: an uncommon complication of cholesterol embolization syndrome]."
12/08/2001 - "Rhabdomyolysis is a rare but potentially fatal complication associated with the use of cholesterol synthesis inhibitors (statins). "
05/08/1993 - "With the exception of rhabdomyolysis and symptomatic liver damage the adverse effects of cholesterol synthesis inhibitors appear to be fairly innocuous. "
03/01/1989 - "The role of cholesterol-lowering agents in drug-induced rhabdomyolysis and polymyositis."

01/01/2014 - "We observed rhabdomyolysis in 6 patients (3.03% of the total 198 patients group) using other types of statins (three of them undergo chronic hemodialysis). "
09/01/2011 - "All four cases of rhabdomyolysis which occurred after such positional urogenital surgeries were treated with conservative management for prolonged period with hemodialysis. "
05/20/2011 - "He presented with pronounced rhabdomyolysis and had to be treated by repeated hemodialysis. "
03/01/2010 - "Perioperative complications include 1 patient with rhabdomyolysis requiring temporary hemodialysis, 1 patient with subsidence, and 1 patient with hardware failure. "
12/01/2007 - "Excessive muscle training may result in severe, hemodialysis-dependent rhabdomyolysis. "

03/01/2005 - "In contrast to a traditional wait-and-see strategy, plasma exchange seems to be a safe and effective treatment in addition to supportive care for rhabdomyolysis in such clinical scenarios."
01/01/1989 - "The effect of plasma exchange (PE) was evaluated in 4 patients with rhabdomyolysis. "
01/01/1989 - "Plasma exchange in rhabdomyolysis."
11/01/1981 - "Successful treatment of fulminating complications associated with extensive rhabdomyolysis by plasma exchange."
01/01/1993 - "Plasma-exchange was effective in improving the signs of rhabdomyolysis and renal failure. "

03/01/2009 - "Thyroid hormone replacement therapy improved thyroid and renal function with involution of rhabdomyolysis. "
01/04/1992 - "Thyroid hormone replacement therapy improved thyroid and renal function, and reversal rhabdomyolysis. "

12/01/2014 - "The last 10 years have seen significant progression and improvement in the treatment of rhabdomyolysis, from minor supportive care to use of continuous renal replacement therapy. "
12/01/2008 - "Studies of risk factors associated with ARF and the need for renal replacement therapy (RRT) in children with rhabdomyolysis-associated pigment nephropathy consist of retrospective case series with variable inclusion criteria. "
05/01/2015 - "Four patients with rhabdomyolysis required a short period of renal replacement therapy. "
01/01/2014 - "Continuous renal replacement therapy (CRRT) for rhabdomyolysis."
05/01/2013 - "We sought to determine the impact of rhabdomyolysis on AKI (defined by the AKI Network classification), renal replacement therapy (RRT), and death. "

05/01/1991 - "Subsequently, he received a liver transplant with remarkable improvement in his mental status, although the rhabdomyolysis continued. "
01/01/2015 - "Rhabdomyolysis is a rare complication of therapy with this drug and is commonly seen in immunocompromised patients or those with an allogenic stem cell transplant. "
09/01/2013 - "Transplant of kidneys from a small pediatric donor with severe rhabdomyolysis."
11/01/2005 - "Between April 1991 and December 2003, we retrospectively evaluated 336 heart transplant patients (including 55 women) with regard to the occurrence of possible adverse effects of statins (rhabdomyolysis, myalgia, hepatotoxicity, high CK without muscle symptoms, and others). "
10/01/2002 - "She subsequently required a heart transplant but developed rhabdomyolysis early in the postoperative period and required ventilatory support for more than 3 weeks. "