Retinitis

01/01/2001 - "Ganciclovir (GCV) implants are highly effective in delaying the progression of cytomegalovirus (CMV) retinitis. "
06/01/2008 - "Four months after presentation, gancyclovir was intravitreously injected a total of 5 times, and the retinitis resolved completely. "
07/01/2005 - "The retinitis resolved completely with systemic ganciclovir. "
02/01/2000 - "High-dose intravitreous ganciclovir induces a prolonged remission of CMV retinitis and is well tolerated. "
04/01/1996 - "Use of NPEM2 led to identification of a subset of patients with CMV retinitis who had a more rapid clearance of ganciclovir of 0.51 to 0.54 L/hr/kg/100 mL/min Cl(cr). "

02/14/1992 - "Foscarnet was well tolerated and effective in delaying progression of CMV retinitis in these patients. "
05/01/1989 - "A pharmacokinetic study was carried out as part of a clinical trial designed to evaluate the safety and efficacy of intermittently administered intravenous foscarnet for the treatment of CMV retinitis. "
01/01/1991 - "Trials with intravenous foscarnet in CMV retinitis have reported favorable results using initial daily doses of 180-230 mg/kg/d given as intermittent infusions every eight hours, followed by maintenance regimens of 60-90 mg/kg/d given as single daily one- or two-hour infusions. "
11/16/2022 - "Active retinitis regressed in both the eye treated with intravitreal foscarnet and the un-injected eye. "
02/01/2014 - "Intravitreal foscarnet for recurring CMV retinitis in a congenitally infected premature infant."

11/01/1999 - "Cidofovir has proved to be highly effective in treatment of CMV retinitis. "
05/01/1997 - "Intravitreal cidofovir has been shown to be a long acting and highly efficacious treatment for CMV retinitis; however decrease in IOP is an adverse effect. "
01/01/1996 - "Two company studies suggest cidofovir is effective against CMV retinitis progression. "
07/28/2000 - "Although effective for the treatment of CMV retinitis, cidofovir has potential toxicity. "
04/01/1995 - "The authors previously conducted a pilot, dose-escalating study which suggested that a 20-micrograms dose of intravitreal cidofovir (HPMPC) may be safe and effective in treating cytomegalovirus (CMV) retinitis in humans. "

01/01/1994 - "The results of the studies suggest three ways CD4+ T cells might contribute to the pathogenesis of herpes simplex virus type 1 retinitis in the uninoculated contralateral eye: (1) accumulation of massive inflammatory cell infiltrates in the retina, (2) induction of retinal destruction, and (3) clearance of herpes simplex virus type 1 from the contralateral eye. "
06/01/1998 - "Twenty-one eyes of 20 patients presented with retinal lesions, and on average, those treated for active retinitis had improvement in vision."
02/01/2022 - "In all study eyes, HMLs were preceded by an area of retinitis-like retinal infiltration and evolved into elevated hemorrhagic masses. "
07/10/2019 - "The purpose of this study was to determine whether autophagy plays a significant role in the death of retinal cells during MCMV retinitis. "
02/01/2015 - "Retinal photography with the camera used in this study was not highly sensitive in detecting CMV retinitis but may identify disease with an immediate threat to vision. "

04/05/2018 - "Combined intravenous and intravitreal antiviral treatment led to rapid improvement with settled retinitis, no vascular occlusion and good recovery of vision. "
07/01/1999 - "To date no antiviral agent has proved effective in preventing reactivation of retinitis. "
01/01/1993 - "This model may be used to evaluate the therapeutic efficacy of new antiviral agents and modalities in the treatment of herpes family viral retinitis. "
04/01/2007 - "The necrotising retinitis responded well to intravitreal antiviral agents. "
01/01/1992 - "Experience in a number of studies not designed to assess mortality has suggested that specific antiviral treatment for CMV retinitis is associated with prolongation of survival. "

11/01/2004 - "Six months after discontinuation of immunosuppressive therapy, CMV retinitis of the left eye occurred but was treated successfully with a second course of oral valganciclovir. "
11/01/2022 - "Development and pharmacokinetic evaluation of osmotically controlled drug delivery system of Valganciclovir HCl for potential application in the treatment of CMV retinitis."
04/03/2021 - "There was no recurrence of retinitis/endotheliitis with a maintenance dose of oral valganciclovir. "
06/01/2020 - "Her retinitis gradually resolved after 3 months of treatment with valganciclovir, with no recurrence 4 months after discontinuing the valganciclovir. "
11/24/2011 - "Valganciclovir is an essential drug for developing successful programs for management of CMV retinitis in China and throughout SE Asia."

01/01/1995 - " 2 Recurrence rate of CMV retinitis in patients following pars plana vitrectomy and silicone oil injection. "
02/01/1994 - "The authors performed a retrospective review of 35 eyes in 30 immunocompromised patients with CMV retinitis and RD who underwent pars plana vitrectomy with the use of silicone oil injection. "
09/01/2012 - "The purpose of this study is to evaluate the results of silicone oil removal (SOR) in post-cytomegalovirus (CMV) retinitis-related retinal detachment in Indian eyes. "
11/01/2005 - "The study cohort consisted of a series of 15 eyes in 14 patients with HIV and CMV retinitis with a retinal detachment (RD) repaired with silicone oil at a single center and followed from the time of the CMV retinitis diagnosis through the time of silicone oil removal. "
01/01/2001 - "These results support the use of combined GCV implants and silicone oil tamponade in patients with CMV retinitis and associated retinal detachment."

04/01/2002 - "Both regimens of intravitreous fomivirsen can be effective treatment for patients with CMV retinitis that has not been controlled by other anti-CMV drugs. "
04/01/1998 - "Clinical trials indicate that Isis Pharmaceuticals' Fomivirsen (ISIS 2922) is a promising treatment for cytomegalovirus (CMV) retinitis. "
01/01/1995 - "Two new trials are studying treatment of CMV retinitis with an antisense drug called ISIS 2922. "
09/01/2006 - "An anti-sense therapeutic, ISIS 2922, is also approved specifically as in intravitreal treatment for CMV retinitis. "
04/01/2002 - "A multicenter, prospective, and randomized clinical trial compared immediate treatment of CMV retinitis with fomivirsen (165 microg administered intravitreously) to deferral of treatment until CMV retinitis lesions progressed by standard definitions. "

12/01/2005 - "Based on this study, the use of steroids systemically elevated the risk of CMV retinitis."
04/18/2023 - "It is imperative to follow-up closely after intravitreal steroid implantation, to look for the possible rare complication of infectious retinitis/retinochoroiditis, as timely antimicrobial treatment can lead to a good visual outcome."
01/01/2023 - "The patient responded to oral steroids, leading to resolution of active retinitis. "
08/11/2021 - "A middle-aged man had been diagnosed as retinitis and treated with steroids previously. "
09/01/2017 - "Here, we report a case of CMV retinitis in a young immunocompetent male who presented with history of progressive loss of vision in both eyes despite receiving oral and intra-vitreal steroids. "

01/01/2010 - "The use of systemic antibiotics in cat scratch neuroretinitis, although proven beneficial in our patients, remains controversial and should probably be reserved for the more severe forms of the disease."
07/01/2023 - "Lack of antibiotics may delay the resolution of retinitis. "
07/01/2023 - "Oral antibiotics were given in five patients (two post-medical termination of pregnancy [MTP]) for the retinitis. "
04/09/2013 - "This evolved into neuroretinitis that resolved upon introducing antitoxoplasma antibiotics."
05/01/2004 - "She had retinitis involving the fovea, subretinal fluid, thickening of the retinal pigment epithelium, and a few vitreous cells; the retinitis resolved with antitoxoplasma antibiotic treatment. "

01/02/2012 - "Highly active anti-retroviral therapy, introduced in 1996, dramatically decreased the incidence of CMV retinitis. "
09/01/1998 - "This increase in CD4+ cells creates a natural protection against CMV in most cases, allowing patients to discontinue maintenance therapy for CMV retinitis. "
01/01/1996 - "Comparison of retinitis progression, as evaluated in a masked fashion by the centralized Fundus Photograph Reading Center (FPRC), revealed that combination therapy was the most effective regimen for controlling the retinitis. "
01/01/1996 - "The cost, toxicity, and limited efficacy of currently available therapy of CMV retinitis make the need for an effective prophylactic drug even more important."
10/01/2001 - "There is evidence to suggest that it is as effective as intravenous GCV for the treatment of CMV retinitis, and it is currently being studied as a pre-emptive therapy in patients at high risk for CMV disease. "

06/01/2002 - "The minimum HIV viral load level reached after the initiation of HAART treatment appears to be more important than other clinical variables in the prediction of favorable CMV retinitis remission status. "
09/01/2001 - "Six months after the initial episode while still under successful HAART, the patient developed an acute episode of retinitis despite a persistent significant improvement in the immunological picture and a very low level of CMV reactivation. "
06/16/2000 - "The introduction of HAART has had a major impact on the natural history of CMV retinitis with improved survival time and decreased risk of progression following diagnosis. "
06/01/2002 - "Proportional hazards analysis was performed to assess the correlation of the nine potential clinical predictors (baseline CD4 count, post-HAART CD4 count, post-HAART rise in CD4 count, baseline weight, post-HAART rise in weight, post-HAART percentage rise in weight, log of baseline HIV viral load, log of minimum post-HAART HIV viral load, and post-HAART log unit reduction in HIV viral load) with the duration of CMV retinitis remission. "
03/01/2008 - "The introduction of highly active antiretroviral therapy (HAART) has markedly reduced the incidence of cytomegalovirus (CMV) retinitis, but has not eliminated new cases altogether. "

06/01/2011 - "After 5 injections, the retinitis was dramatically improved. "
12/01/2022 - "After 3 injections, clinical signs of CMV retinitis started to resolve in all eyes (100%). "
09/01/2013 - "Local immunosuppression, the dose and the frequency of injections may explain the occurrence of this severe retinitis. "
03/01/2010 - "Our high reported incidence for this potentially devastating complication can be attributed to multiple factors, including coexisting medical immunocompromising comorbidities, a higher dose with a longer duration of local immunosuppression in the vitreous, multiple injections, as well as previous viral retinitis. "
11/01/2005 - "The number of eyes achieved inactive retinitis and corresponded to the number of injections, number of relapses and corresponded duration, visual acuity during the injection, and complications of the injection. "

06/01/2013 - "Compared with systemic treatment only, regimens containing intravitreal injections had greater rates of retinitis progression (adjusted HR, 3.4; P = 0.004) and greater visual field loss (for loss of one half of the normal field, adjusted HR, 5.5; P < 0.01). "
09/01/2005 - "Intravitreal injections were discontinued once CMV retinitis healed if there was a significant increase in CD4+ count (any increase of > or 50 cells/microL to levels over 100 cells/microL sustained for at least 3 months). "
05/01/2000 - "In order to determine the possible mechanisms leading to bilateral retinitis, we studied the pathways by which herpes simplex virus type 1 (HSV-1) is propagated from one retina to the other after intravitreal injection in mice. "
12/01/1996 - "The CMV antigenemia assay may be a simple and rapid means of identifying those patients with unilateral retinitis at highest risk of developing CMV retinitis of the fellow eye or of visceral CMV disease if intravitreal injections or implants are used as sole treatment for CMV retinitis."
07/01/1996 - "To assess the evolution of cytomegalovirus (CMV) retinitis and evaluate the possible complications associated with the use of intravitreal injections to treat this disease. "

09/01/2020 - "Pars plana vitrectomy revealed necrotizing retinitis with poor visual prognosis. "
12/01/2005 - "A presumptive diagnosis of viral retinitis was made, and a vitrectomy was performed. "
08/01/1986 - "[Preventive vitrectomy in acute necrotizing retinitis]."
10/01/2010 - "After therapeutic vitrectomy for intercurrent vitreous hemorrhage, and while still under treatment, the retinitis resolved completely with final visual acuity of 20/25. "
09/23/2019 - "Vision improved after implantation, however, due to retinitis a vitrectomy was performed proving infection with cytomegalovirus. "