Retinal Diseases

01/01/2022 - "The datasets we generated constitute an excellent resource for the continued improvement of retinal organoid technology and have the potential to inform and accelerate regenerative medicine approaches to retinal diseases."
11/01/2019 - "biloba extracts might be a good option to improve certain neurodegenerative retinal diseases, but more research is needed to determine the safety and efficacy of G. biloba in these retinal degenerative processes."
04/07/2004 - "The facility to image with several different wavelengths simultaneously offers the potential for spectral imaging of retinal tissue with the aim of revealing those early changes in tissue perfusion that indicate the onset of retinal disease, so increasing the probability of successful therapy."
03/15/2023 - "These automated techniques can provide ophthalmologists with valuable tools for improved interpretation and quantification of retinal features, leading to more accurate diagnosis and informed treatment decisions for retinal diseases. "
01/01/2023 - "The unique metabolic phenotype of different retinal regions is likely due to the differential distribution of different cell types in these regions reflecting the specific metabolic requirements of each cell type. Our results may help to better understand the pathobiology of retinal diseases with region specificity."

12/01/2022 - "-vascular endothelial growth factor (anti-VEGF) and its longer-acting agents have dramatically improved visual outcomes and have become a mainstay treatment in various retinal diseases.Gene"
01/01/2022 - "The first-line treatment for these exudative retinal diseases consists of anti-vascular endothelial growth factor (VEGF) agents; however, the high treatment burden and the percentage of 'non responder' patients have highlighted the need for other approaches. "
02/01/2021 - "Targeting the vascular endothelial growth factor (VEGF)/its receptor-2 (VEGFR-2) system has become a mainstay of treatment for many human diseases, including retinal diseases. "
10/08/2010 - "Over the past decade, anti-VEGF therapeutic agents have entered the clinic for the treatment of neovascular retinal disease, and these agents have been effective for slowing and preventing the progression of neovascularization. "
01/01/2019 - "Anti-VEGF medication use is now considered first-line treatment for numerous retinal diseases globally. "

03/12/2023 - "Ginkgo biloba extracts (GBE) have been reported to possess antioxidant property, beneficial in treating human retinal diseases. "
11/17/2023 - "In this respect, the antioxidant treatment approach is effective against neuronal oxidative damage and represents a challenge for retinal diseases. "
01/01/2021 - "This oxidative stress has been implicated in the pathogenesis of several retinal diseases and the role of antioxidants as a therapeutic treatment shows promise in slowing the progression of certain diseases. "
01/01/2021 - "This study assessed the anti-oxidant effects of 19 natural compounds isolated from GBE to provide a rational basis for their use in preventing retinal diseases. "
01/01/2022 - "When ROS exceeds the body's natural antioxidants, the retina is in a state of oxidative stress, which is recognized as the pathogenesis of retinal diseases. "

01/01/2019 - "The reconstitution of large therapeutic proteins using this approach improved the phenotype of two mouse models of inherited retinal diseases. "
01/01/2023 - "However, due to the posterior location and chronic nature of retinal diseases, a safe and effective intraocular protein delivery system is currently lacking. "
01/01/2023 - "This study aimed to develop a prediction model to classify RPE65-mediated inherited retinal disease (IRDs) based on protein secondary structure and to analyze phenotype-protein structure correlations of RPE65 missense variants in a Chinese cohort. "
05/18/2022 - "The overexpression and knockout studies of UCP2 in mice have established the ability of this protein to provide neuroprotection in a number of animal models of neurological disease, including retinal diseases. "
08/01/2017 - "These cultures were used to study autofluorescence and barrier formation, as well as activities such as outer-segment internalisation/trafficking and directional secretion of key proteins; the impairment of which underlies retinal disease. "

03/31/2023 - "However, improved imaging resolution could aid diagnosis and monitoring of retinal diseases and identify potential new imaging biomarkers. "
01/01/2024 - "Applications of AO show great promise in advancing our understanding of the etiology of inherited retinal disease (IRDs) and discovering new imaging biomarkers. "
01/01/2021 - "Increasing studies have suggested that EVs may be biomarkers for liquid biopsy of retinal diseases due to the ability to transfer through the blood-retinal barrier. "
11/01/2019 - "In this way, reflectance properties of photoreceptor substructures are highlighted, enabling physicians to study their orientation, which is potentially an interesting biomarker for retinal diseases. "
05/01/2018 - "Studies involving mass spectrometry (MS) and nuclear magnetic resonance (NMR) spectroscopy have shown that individuals suffering from retinal diseases exhibit metabolic profiles that markedly differ from those of control individuals, supporting the notion that metabolites may serve as easily identifiable biomarkers for specific conditions. "

04/01/2011 - "Intravitreal bevacizumab appears to be a well-tolerated treatment for pediatric age group with various exudative retinal diseases. "
09/11/2021 - "The sample size was calculated and the study enrolled all patients who received intravitreal Bevacizumab for retinal diseases using convenience sampling technique. "
09/11/2021 - "This study aims to find out the prevalence of the use of intravitreal Bevacizumab for retinal diseases at the tertiary eye hospital. "
10/01/2019 - "Accordingly, despite its off-label status, bevacizumab is frequently used for a variety of disabling retinal diseases. "
09/11/2019 - "Costs and benefits of bevacizumab vial sharing for the treatment of retinal diseases."

10/01/2017 - "Long-term safety and efficacy of ziv-aflibercept in retinal diseases."
09/01/2021 - "Over the years, a number of studies have evaluated the use of intravitreal aflibercept in different retinal diseases. "
01/01/2019 - "Systemic pharmacokinetic/pharmacodynamic analysis of intravitreal aflibercept injection in patients with retinal diseases."
01/01/2019 - "Using TAE regimen, intravitreal ziv-aflibercept appeared efficacious at managing retinal disease through month 30 using the TAE regimen."
10/01/2017 - "Consecutive patients with retinal disease receiving six or more of intravitreal 0.05 mL ziv-aflibercept (1.25 mg) injections were followed monthly in three centres. "

11/01/2013 - "The ability to use the clinical history and examination along with additional ancillary testing including OCT, electrophysiology, and fluorescein angiography to differentiate optic nerve from retinal disease can be very helpful in formulating a differential and ultimately establishing a diagnosis."
01/01/2001 - "To study the efficacy of oral fluorescein angiography compared to intravenous (IV) fluorescein angiography in several retinal diseases. "
01/01/1991 - "Directly acquired images of fluorescein angiography may be helpful in the treatment of retinal diseases. "
08/01/1999 - "We carried out a study to determine the prevalence of retinal diseases in Chinese-Canadians presenting for fluorescein angiography compared to a matched group of Canadians of European origin. "
10/17/2023 - "Ischemic retinal diseases (IRDs) are a series of common blinding diseases that depend on accurate fundus fluorescein angiography (FFA) image interpretation for diagnosis and treatment. "

06/13/2017 - "We modified and reconstructed a high image quality portable non-mydriatic fundus camera and compared it with the tabletop fundus camera to evaluate the efficacy of the new camera in detecting retinal diseases. "
11/09/2012 - "To construct a low-cost, easy-to-use, high-image-quality mydriatic fundus camera with "point-and-shoot" operation, and to evaluate the efficacy of this camera to accurately document retinal disease. "
10/01/2020 - "The purpose of this study was to compare a handheld nonmydriatic digital fundus camera and a conventional mydriatic fundus camera according to the image quality of their photographs and usability of those photographs to accurately diagnose various retinal diseases. "
06/13/2017 - "Telemedicine screening of retinal diseases with a handheld portable non-mydriatic fundus camera."
03/01/2011 - "Single-field non-mydriatic fundus photography is accurate and sensitive for screening retinal disease in a primary care setting."

08/01/2022 - "Glutamate excitotoxicity can cause cell damage and apoptosis and play an important role in a variety of retinal diseases. "
01/01/2021 - "Glutamate excitotoxicity is considered one of the major causes of retinal ganglion cell death in many retinal diseases. "
01/01/2013 - "Abnormalities in glutamate metabolism and excitotoxicity in the retinal diseases."
06/10/2010 - "ATRA may be useful as a therapeutic drug against retinal diseases that cause glutamate neurotoxicity."
02/27/2008 - "Glutamate toxicity has been implicated in various retinal diseases. "

01/01/2018 - "For each approach, we provide background on the neuroprotective strategy, including history of use in other diseases; describe potential mechanisms of action; review the body of research performed in the retina thus far, both in animals and in humans; and discuss considerations when translating each treatment to the clinic and to the retina, including which therapies show the most promise for each retinal disease. "
01/01/2018 - "Intravitreal therapy has proven highly effective for the treatment of many retinal diseases. "
10/11/2021 - "Currently, there are no proven effective cell-based treatments for retinal diseases, although several trials have investigated potential therapies. "
08/07/2006 - "The ability to resolve single cells noninvasively in the living retina has important applications for the study of normal retina, diseased retina, and the efficacy of therapies for retinal disease. "
07/01/2017 - "It is paramount to apply a strong level of scientific rigor toward a well-planned, step-wise sequence of preclinical and clinical studies, to determine whether this class of potential therapies will be safe and effective for individuals with retinal diseases."

07/01/2023 - "However, the optimal management of chronic retinal diseases requires frequent intravitreal injections over extended periods of time. "
01/01/2019 - "The realization of intravitreal injections and the vast utilization of this methodology in retinal disease management deepened the need for new drug delivery methods for drugs already approved safe and effective. "
02/01/2022 - "In this cohort and survey study, consecutive adult patients attending Moorfields Eye Hospital receiving intravitreal injections for retinal disease between May 2020 and February 2021 were included. "
07/01/2018 - "In an actual-use formative usability study (ClinicalTrials.gov identifier: NCT02698566), three assistants and three retina specialists prepared the PFS and performed intravitreal injections, respectively, in study eyes of patients with retinal diseases (n = 35). "
11/20/2023 - "Intravitreal injection is widely employed for the treatment of retinal diseases. "

01/01/2019 - "Malfunctions within the RPE are implicated in several retinal diseases for which transplantations of stem cell-derived RPE are promising treatment options. "
08/01/2021 - "Preclinical trials in animal models of retinal diseases have shown improvement in visual outcomes following subretinal transplantation of PSC-derived photoreceptors or retinal pigment epithelium (RPE) cells. "
11/07/2023 - "Taken together, this ex vivo model can be used to study inflammatory retinal diseases like AMD as well as the rejection observed after RPE-transplantation."
01/01/2015 - "This provides a reliable platform for studying the therapeutic targets, testing the effects of drugs in a preclinical setup and to perform in vitro and in vivo transplantation experiments to study retinal diseases. "
01/01/2013 - "Moreover, it will be discussed why the development of clinical trials for the genetic modification of corneal grafts prior to transplantation is lagging behind of those for the treatment of inherited retinal diseases. "

01/01/2022 - "The PubMed, Cochrane Library, and Embase databases were comprehensively searched to identify studies that compared 3D HUD versus SOM in vitrectomy for retinal diseases (PROSPERO protocol CRD42021265827). "
01/01/2018 - "In this nonrandomized prospective study, 75 patients (34 females and 41 males) referred to pars plana vitrectomy (PPV) due to different retinal diseases were enrolled to the study. "
07/01/1997 - "[Immunohistochemical study on vitrectomy specimens of proliferative retinal diseases]."
05/24/2023 - "Pars Plana Vitrectomy in Inherited Retinal Diseases: A Comprehensive Review of the Literature."
01/01/2022 - "In elderly patients with retinal diseases, the vitrectomy group showed the lower mortality from pulmonary causes with no association for all-cause mortality."

06/01/2023 - "Yellow Subthreshold Micropulse Laser in Retinal Diseases: An In-Depth Analysis and Review of the Literature."
02/11/2022 - "Eyes with previous laser treatment or concomitant retinal disease were excluded. "
02/13/2019 - "Subthreshold micropulse laser treatment has been intensively used for selected retinal diseases in the last decade; however, the exact mechanism of the action of lasers in the subthreshold micropulse mode is not yet fully understood. "
02/13/2019 - "Micropulse Laser Treatment of Retinal Diseases."
11/01/2016 - "The development of lasers for biological use was an important medical advance in the 20th century with numerous evidence-based therapeutic applications to retinal disease, including capillary leakage at the macula. "