Retinal Diseases

04/07/2004 - "The facility to image with several different wavelengths simultaneously offers the potential for spectral imaging of retinal tissue with the aim of revealing those early changes in tissue perfusion that indicate the onset of retinal disease, so increasing the probability of successful therapy."
10/01/2014 - "These three cases demonstrate that application of epigenetics has long-term efficacy against AMD retinal disease, when the retinal specialist has exhausted other therapeutic modalities."
12/01/2011 - "The present results suggest that pathogenic angiogenesis, a key change in many hypoxic/ischemic vision-threatening retinal diseases, depends at least in part on β(2) -AR activity and indicate that β(2) -AR blockade can be effective against retinal angiogenesis."
12/01/2015 - "The application of microfluidics technologies to the study of retinal function and response holds great promise for development of new and improved treatments for patients with degenerative retinal diseases. "
03/01/2010 - "The safety of the intervention and the stability of the improvement in visual and retinal function in these subjects support the use of AAV-mediated gene augmentation therapy for treatment of inherited retinal diseases."

01/01/2010 - "Over the past decade, anti-VEGF therapeutic agents have entered the clinic for the treatment of neovascular retinal disease, and these agents have been effective for slowing and preventing the progression of neovascularization. "
11/01/2014 - "Various large-scale studies show the efficacy of anti-vascular endothelial growth factor (VEGF) therapy in treatment of retinal diseases. "
12/01/2013 - "A teleconsultation network improves the efficacy of anti-VEGF therapy in retinal diseases."
01/15/2014 - "2013 has been the year of publications of large multicentric studies defining the modalities of different anti-VEGF and corticoid implants for the treatment of retinal diseases. "
07/01/2012 - "This study indicates a critical role of p38alpha in VEGF-induced permeability and offers a new strategy for developing potent and specific therapies for treatment of retinal diseases associated with vascular barrier dysfunction."

11/01/2013 - "The ability to use the clinical history and examination along with additional ancillary testing including OCT, electrophysiology, and fluorescein angiography to differentiate optic nerve from retinal disease can be very helpful in formulating a differential and ultimately establishing a diagnosis."
01/01/2001 - "To study the efficacy of oral fluorescein angiography compared to intravenous (IV) fluorescein angiography in several retinal diseases. "
01/01/1991 - "Directly acquired images of fluorescein angiography may be helpful in the treatment of retinal diseases. "
08/01/1999 - "We carried out a study to determine the prevalence of retinal diseases in Chinese-Canadians presenting for fluorescein angiography compared to a matched group of Canadians of European origin. "
05/01/2014 - "Ultra-wide-field fluorescein angiography in retinal disease."

02/01/2015 - "The LXR agonists may become a new class of neuroprotective agent for retinal diseases associated with glutamate-induced excitotoxicity."
01/01/2013 - "Abnormalities in glutamate metabolism and excitotoxicity in the retinal diseases."
06/10/2010 - "ATRA may be useful as a therapeutic drug against retinal diseases that cause glutamate neurotoxicity."
02/27/2008 - "Glutamate toxicity has been implicated in various retinal diseases. "
06/01/2002 - "Low concentrations of excitotoxic agents such as glutamate decrease survival of retinal ganglion cells (RGCs) and may be an important cause of RGC death in a variety of retinal diseases. "

01/01/2012 - "In this article, we consider some applications of nanotechnology that may be useful for the treatment of degenerative retinal diseases, for example, use of nanoparticles for drug and gene therapy, use of nanomaterials for neural interfaces and extracellular matrix construction for cell-based therapy and neural prosthetics, and the use of bionanotechnology to re-engineer proteins and cell behavior for regenerative medicine."
02/01/2011 - "The aim of this study was to further characterise these neurites by examining the expression of additional specific proteins in human ERMs and to correlate this expression with various retinal disease conditions. "
03/01/2015 - "Ciliopathies refer to a wide variety of diseases in which mutations in the genes encoding proteins involved in ciliogenesis or protein transport to the primary cilia play pathogenetic roles, and in such diseases, retinal involvement may be present. "
08/01/2013 - "Recent work has revealed the presence of phosphorylated signaling proteins in the vitreous humour of patients affected by AMD or other retinal diseases. "
11/01/2011 - "The feasibility to transfer gene into the ciliary muscle by US and MB suggests that sonoporation may allow intraocular production of proteins for the treatment of inflammatory, angiogenic and/or degenerative retinal diseases."

11/18/2011 - "Little is known about the epigenetic regulations during HIF-mediated transcription and activation of pro-angiogenic genes in oxygen-dependent retinal diseases. "
04/28/2011 - "These results indicate that Akt play a critical role in the pathological process (vessels loss and neovascularization) of mouse model of oxygen-induced retinopathy, which may provide a valubale therapeutic tool for ischemic-induced retinal diseases."
01/01/2010 - "Longer periods of oxygen therapy use were associated with more severe retinal disease (p<0.05). "
11/01/2006 - "Measurement of changes in the chorioretinal vasculature P(O2) can potentially advance the understanding of oxygen dynamics in challenged physiological states and in animal models of human retinal diseases."
03/16/2005 - "[Guideline for oxygen therapy of premature infants and prevention of retinal diseases]."

04/01/2011 - "Intravitreal bevacizumab appears to be a well-tolerated treatment for pediatric age group with various exudative retinal diseases. "
04/01/2011 - "Intravitreal bevacizumab for pediatric exudative retinal diseases."
01/01/2014 - "Bevacizumab repackaged in single-use syringes results from the off-label use of the drug as an intravitreal agent in the treatment of retinal diseases. "
10/10/2012 - "The present results need to be considered when multiple intravitreal injection of bevacizumab are performed to treat retinal diseases."
01/01/2011 - "Aqueous samples collected from patients receiving intravitreal injection of bevacizumab for various retinal diseases were divided into two groups. "

10/01/2013 - "Polypoidal choroidal vasculopathy (PCV) is a retinal disease involving the choroidal vasculature characterized by the presence of polypoidal lesions with or without branching vascular network best seen on indocyanine green angiography (ICGA). "
07/01/2002 - "To observe the effect of indocyanine green angiography (ICGA) with infrared fundus camera on subsequent dark adaptation and the Ganzfeld electroretinogram (ERG), the ERGs of 38 eyes with different retinal diseases were recorded before and after ICGA during a 40-min dark adaptation period. "
11/01/2013 - "The switch to Indocyanine Green angiography helped to pinpoint PCV, and thus to study the efficacy of photodynamic therapy of this particular form of retinal disease, which is more frequently encountered among pigmented individuals. "
01/01/2001 - "In the future, OCT combined with FAG or indocyanine-green angiography will be a useful tool for the evaluation of animal studies of choroidal neovascularization and other retinal diseases."
04/01/1998 - "Fluorescein and indocyanine green (ICG) angiography are both useful in the diagnosis and treatment of many retinal diseases. "

02/01/1983 - "Tested on a number of normal eyes and on eyes with confirmed or suspected retinal disease it appears to be very useful as a complement to the standard program with the Krakau-Ohman apparatus. "
01/01/2012 - "Recent studies have implicated the complement system as an emerging player in the etiology of several retinal diseases. "
04/01/2015 - "Our observations provide new insight into the potential role of the complement system in photoreceptor loss, with implications for the molecular aetiology of retinal disease. "
01/01/2014 - "These findings provide evidence of activation of complement during natural aging, and may have relevance to cellular events underling the pathogenesis of age-related retinal diseases."
12/01/2013 - "These results indicate that complement can regulate Müller cells through C5aR, which may contribute to the pathogenesis of retinal diseases, including DR."

01/01/2015 - "There have also been promising results achieved recently with LPD nanoparticles to deliver functional genes and micro RNA to treat retinal diseases. "
12/01/2013 - "This knowledge will improve the design and interpretation of future functional studies of the role of miRNAs and other small RNAs in retinal disease."
04/01/2015 - "We developed a targeted panel of 164 known retinal disease genes, 88 candidate genes, and 32 retina-abundant microRNAs, used for exome sequencing. "
01/01/2015 - "Our data on alterations of miRNAs and their target gene expression after Müller cell ablation provide further insights into the potential role of Müller cell dysfunction in retinal disease. "
09/23/2014 - "This list was enriched in rod and cone photoreceptor genes and included 28 retinal disease genes, providing further evidence of a role of miRNAs in the pathology of blinding diseases. "

10/01/2015 - "To evaluate the variation of peripheral alterations in different retinal diseases over a period of >3 years by using wide-field fundus autofluorescence (FAF) scanning laser ophthalmoscopy (SLO). "
09/01/2014 - "This review will describe briefly the current techniques and discuss in detail the reported side-effects and potential complications of laser treatment of diabetic retinal disease."
09/01/2014 - "Side-effects and complications of laser treatment in diabetic retinal disease."
10/01/2013 - "Although the characteristic onset of enhanced S-cone syndrome can be well-documented by current ophthalmic imaging modalities, techniques such as spectral-domain optical coherence tomography (SD-OCT) and scanning laser ophthalmoscopy (SLO) fail to provide sufficient details regarding the microstructure of photoreceptors in retinal diseases. "
04/01/2007 - "Selective targeting of the retinal pigment epithelium (RPE) with repetitive laser pulses that minimize thermal damage to the adjacent photoreceptors is a promising new therapeutic modality for RPE-related retinal diseases. "

06/01/1982 - "In 4 patients with proliferative retinopathy, progression of retinal disease was arrested with photocoagulation during pregnancy. "
06/01/1981 - "However, platelet survivals performed in three diabetic patients who had severe retinal disease requiring photocoagulation were significantly shortened compared with nonsmoking control subjects (P less than 0.05) or to patients without severe retinopathy (P less than 0.01). "
01/01/1980 - "The role of photocoagulation in the treatment of retinal disease."
03/01/1962 - "Light coagulation in retinal disease."
04/01/1961 - "Light coagulation in the treatment of retinal disease."

03/01/2003 - "The use of photodynamic therapy at retinal diseases, caused by the onset of new-vascular membranes due to the age-related degeneration of the macular, is under discussion. "
11/01/2013 - "The switch to Indocyanine Green angiography helped to pinpoint PCV, and thus to study the efficacy of photodynamic therapy of this particular form of retinal disease, which is more frequently encountered among pigmented individuals. "
01/01/2006 - "Two-photon excitation photodynamic therapy (TPE-PDT) is being developed as an improved treatment for retinal diseases. "
04/01/2015 - "Types of lasers used in treatment of retinal diseases include argon, diode, dye and multicolor lasers, micropulse lasers and lasers for photodynamic therapy. "

04/01/2014 - "The diode laser is an effective and beneficial treatment modality in the management of proliferative retinopathies and some retinal diseases."
04/01/2014 - "INITIAL EXPERIENCE WITH TRANSPUPILLARY DIODE LASER PHOTOCOAGULATION FOR RETINAL DISEASES."
02/01/1991 - "These results suggested that diode laser photocoagulation might be effective for the treatment of the choroidal diseases rather than retinal diseases, because diode laser photocoagulation produced the considerable change in the choroid as well as in the retina."

01/01/2015 - "This provides a reliable platform for studying the therapeutic targets, testing the effects of drugs in a preclinical setup and to perform in vitro and in vivo transplantation experiments to study retinal diseases. "
08/01/1991 - "Both models have recently been used in successful RPE-cell and/or photoreceptor-cell transplantation studies designed to replace defective or lost cells due to retinal disease or damage. "
11/01/2014 - "We demonstrated the potential benefits of non-c-Myc iPSC transplantation for treating oxidative-damage-induced retinal diseases. "
01/13/2014 - "Our data suggest that transplantation of RPCs into the SRS and the SC may be a possible method for cell replacement therapy for retinal diseases."
11/01/2013 - "These findings suggest that rMSCs transplantation could be a new therapy for degenerative retinal diseases since it can protect and rescue RPE and retinal neurons, while EPO gene modification to rMSCs could be an even better option. "