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Reticulin (Reticular Fiber)

A scleroprotein fibril consisting mostly of type III collagen. Reticulin fibrils are extremely thin, with a diameter of between 0.5 and 2 um. They are involved in maintaining the structural integrity in a variety of organs.

Also Known As:

Reticular Fiber; Reticulin Fibers; Reticular Fibers; Reticular Fibril; Reticular Fibrils; Reticulin Fiber; Reticulin Fibril; Reticulin Fibrils; Fiber, Reticular; Fiber, Reticulin; Fibers, Reticular; Fibers, Reticulin; Fibril, Reticular; Fibril, Reticulin; Fibrils, Reticular; Fibrils, Reticulin

Networked: 769 relevant articles (14 outcomes, 42 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Thiele, J: 13 articles (12/2006 - 01/2000)
2.	Kvasnicka, H M: 13 articles (12/2006 - 01/2000)
3.	Orazi, Attilio: 9 articles (07/2015 - 12/2004)
4.	Kuter, David J: 6 articles (05/2013 - 11/2007)
5.	Leder, L D: 6 articles (02/2001 - 01/2000)
6.	Hasserjian, Robert P: 5 articles (05/2015 - 03/2002)
7.	Tefferi, Ayalew: 5 articles (04/2014 - 06/2002)
8.	Kantarjian, Hagop M: 4 articles (10/2015 - 07/2005)
9.	Bueso-Ramos, Carlos E: 4 articles (10/2015 - 07/2004)
10.	Vannucchi, Alessandro M: 4 articles (04/2014 - 05/2009)

Related Diseases

1.	Fibrosis (Cirrhosis) 06/01/2002 - "Intraplatelet PDGF levels were low before treatment (P < 0.006) and normal on hematological remission, without relation with the presence or absence of reticulin fibrosis in bone marrow. " 01/01/2014 - "A bone marrow study showed hypercellular marrow with reticulin fibrosis. " 05/15/2013 - "This study sought to assess the prognostic impact of BM reticulin fibrosis in patients with previously untreated CLL. " 01/01/1994 - "The aim of the study was the evaluation of bone marrow reticulin fibrosis in non-treated patients suffering from chronic granulocytic leukaemia (cgl). " 01/01/1989 - "Actuarial survival studies demonstrated that marked diffuse reticulin fibrosis (p = 0.0005) and more than 15 megakaryocytes/mm3 of marrow tissue (p = 0.01) were associated with a poorer prognosis. "
2.	Carcinoma (Carcinomatosis) 03/01/1987 - "[The origin and biological significance of reticular fiber in the stroma of cervical carcinoma]." 12/01/1980 - "The reticulin fiber forming cells in culture of human ovarian carcinoma." 01/01/2015 - "The reticulin staining method was a useful tool for rapid differentiation of adrenocortical adenomas and carcinomas. " 04/01/1990 - "Four such tumours were examined for evidence of metaplastic transition from carcinoma to sarcoma using morphology and reticulin stains. " 01/01/1982 - "The high mitotic rate, the typical reticulin pattern and the obviously malignant osteoblasts excluded a spindle cell carcinoma with osseous metaplasia. "
3.	Hepatocellular Carcinoma (Hepatoma) 01/01/2011 - "Special stains, such as reticulin stain and CD34 immunostain, are very helpful in the diagnosis of well differentiated hepatocellular carcinoma (HCC). " 12/01/1992 - "We found that the architectural features of thickened cell plates, formation of trabeculae and loss of reticulin were usually very helpful in differentiating benign macroregenerative nodules from hepatocellular carcinoma. " 11/01/2015 - "The 3.0-cm nodule showed small cell change, thickened hepatocyte plates, pleomorphic and hyperchromatic nuclei, reticulin loss, and stromal and vascular invasion, diagnostic of hepatocellular carcinoma (HCC). " 09/01/2013 - "Diagnostic value of immunohistochemical staining of GP73, GPC3, DCP, CD34, CD31, and reticulin staining in hepatocellular carcinoma." 05/01/2012 - "In conclusion, reticulin loss that reaches levels seen in hepatocellular carcinoma can be seen focally in benign liver tissues with fatty change. "
4.	Neoplasms (Cancer) 09/01/2013 - "The reticulin algorithm for adrenocortical tumor diagnosis: a multicentric validation study on 245 unpublished cases." 09/01/1991 - "These findings suggest that reticulin staining of crush preparations should be performed as an adjunct to routine cytologic staining of crush preparations and the study of frozen sections in making the intraoperative diagnosis of these tumors." 07/01/2015 - "The surgical specimen was a 50-mm solid multinodular tumor that microscopically consisted of 3-cell-thick plates of hepatocyte-like cells with acinar, pseudoglandular, and trabecular architecture, intermingled with peliotic areas, without nuclear atypia and disintegrated reticulin framework. " 06/01/2015 - "A 'honeycomb' pattern of reticulin highlighted individual tumor cells in viable regions of all cases. " 09/01/2013 - "We conclude that reticulin staining is a reliable technique and an easy-to-interpret system in adrenocortical tumors; moreover, it has a high interobserver reproducibility, which supports the notion of using such a method in the proposed 2-step RA approach for ACC diagnosis. "
5.	Celiac Disease (Celiac Sprue) 06/01/1993 - "Anti-reticulin antibody (ARA) in gluten-sensitive enteropathy." 02/01/1993 - "Anti-reticulin antibody in gluten sensitive enteropathy." 03/14/1992 - "R1 anti-reticulin antibody as marker of subclinical gluten enteropathy." 05/01/1987 - "Antibody directed to reticulin is usually associated with celiac disease; however, none of the patients had symptoms or signs of celiac disease. " 11/01/1985 - "The results suggest an association between in vitro reticulin binding and the ability to induce gluten sensitive enteropathy on feeding."

Related Drugs and Biologics

1.	Collagen
2.	Antibodies
3.	Immunoglobulin A (IgA)
4.	Silver
5.	Immunoglobulin G (IgG)
6.	Keratins (Keratin)
7.	Glial Fibrillary Acidic Protein
8.	anagrelide (Agrylin)
9.	Mucin-1 (CA 15-3 Antigen)
10.	Collagenases (Collagenase)

Related Therapies and Procedures

1.	Bone Marrow Transplantation (Transplantation, Bone Marrow)
2.	Transplants (Transplant)
3.	Drug Therapy (Chemotherapy)
4.	Aftercare (After-Treatment)
5.	Segmental Mastectomy (Lumpectomy)