Restless Legs Syndrome (Restless Legs)

A disorder characterized by aching or burning sensations in the lower and rarely the upper extremities that occur prior to sleep or may awaken the patient from sleep. Complying with an irresistible urge to move the affected limbs brings temporary relief. Sleep may become disrupted, resulting in excessive daytime hypersomnolence. This condition may be associated with UREMIA; DIABETES MELLITUS; and rheumatoid arthritis. Restless Legs Syndrome differs from NOCTURNAL MYOCLONUS SYNDROME in that in the latter condition the individual does not report adverse sensory stimuli and it is primarily a sleep-associated movement disorder. (Adams et al., Principles of Neurology, 6th ed, p387; Schweiz Rundsch Med Prax 1997 Apr 30;86(18):732-736)
Also Known As:
Restless Legs; Ekbom's Syndrome; Ekboms Syndrome; Syndrome, Ekbom; Syndrome, Ekbom's; Ekbom Syndrome
Networked: 1004 relevant articles (109 outcomes, 203 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Parkinson Disease (Parkinson's Disease)
2. Pain (Aches)
3. Restless Legs Syndrome (Restless Legs)
4. Sleep Initiation and Maintenance Disorders (Insomnia)
5. Schizophrenia (Dementia Praecox)


1. Allen, Richard P: 40 articles (03/2015 - 11/2002)
2. Trenkwalder, Claudia: 37 articles (04/2014 - 01/2002)
3. Earley, Christopher J: 30 articles (01/2015 - 05/2004)
4. Kohnen, Ralf: 24 articles (01/2015 - 10/2003)
5. Högl, Birgit: 22 articles (09/2015 - 08/2005)
6. Ferini-Strambi, Luigi: 22 articles (03/2015 - 11/2003)
7. Stiasny-Kolster, Karin: 22 articles (08/2014 - 01/2004)
8. Garcia-Borreguero, Diego: 17 articles (01/2016 - 06/2004)
9. Oertel, Wolfgang H: 17 articles (08/2014 - 01/2004)
10. Walters, Arthur S: 17 articles (12/2013 - 07/2002)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Restless Legs Syndrome:
1. Dopamine Agonists (Dopamine Agonist)IBA
2. pramipexol (pramipexole)FDA LinkGeneric
01/01/2010 - "Pramipexole group showed a significant reduction in the International Restless Legs Syndrome Study Group rating scale (IRLS; p=0.0005), a significant improvement in both Patient Global Impression (PGI; p<0.0001) and Clinical Global Impressions (CGI-I; p=0.0488), and a significantly greater mean reduction in the Pittsburgh Sleep Quality Index (PSQI; p=0.0016), when compared with those of placebo group at week 6. Pramipexole is highly efficacious in the reduction of PLMI and in the improvement of subjective severity of RLS and subjective sleep disturbance caused by the disorder."
01/01/2012 - "Of 287 patients in the full analysis set, the pramipexole group showed significant improvement compared with the placebo group in the change of their International Restless Legs Syndrome Study Group Rating Scale of Severity (IRLS) total score from baseline to week 6 after adjustment of centers and baseline characters (-15.87±0.66 vs. -11.35±0.92, p<0.0001) and in the proportion of patients who were "much improved" and "very much improved" when measured by Clinical Global Impressions-Improvement (81.9% vs. 54.3%, p<0.0001). "
04/01/2011 - "Pramipexole is an effective treatment for restless legs syndrome (RLS), but no controlled studies have lasted >12 weeks. "
01/20/2007 - "Fifty-one patients suffering from idiopathic restless legs syndrome underwent monotherapy with pramipexole in daily doses of 0.25 to 1.0 mg. Therapeutic efficacy was evaluated using three tools, i.e. "
07/15/2010 - "A phase III, open-label, long-term clinical study was performed to evaluate the safety and efficacy of pramipexole in a cohort of 141 Japanese patients with primary restless legs syndrome (RLS). "
3. IronIBA
4. Levodopa (L Dopa)FDA LinkGeneric
5. ropinirole (Requip)FDA LinkGeneric
6. N 0437FDA Link
7. Dopamine Agents (Dopaminergic Agents)IBA
8. 1- (((alpha- isobutanoyloxyethoxy)carbonyl)aminomethyl)- 1- cyclohexaneacetic acidIBA
9. Opioid Analgesics (Opioids)IBA
10. Pergolide (Permax)FDA Link

Therapies and Procedures

1. Transdermal Patch
2. Renal Dialysis (Hemodialysis)
3. Deep Brain Stimulation
4. Aftercare (After-Treatment)
5. Kidney Transplantation