Reserpine (Serpasil)

An alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria. Reserpine inhibits the uptake of norepinephrine into storage vesicles resulting in depletion of catecholamines and serotonin from central and peripheral axon terminals. It has been used as an antihypertensive and an antipsychotic as well as a research tool, but its adverse effects limit its clinical use.

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Networked: 2387 relevant articles (102 outcomes, 222 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Silva, Regina H: 19 articles (01/2022 - 05/2002)
2.	Ribeiro, Alessandra M: 13 articles (01/2022 - 08/2008)
3.	Santos, José R: 10 articles (01/2022 - 05/2012)
4.	Abílio, Vanessa C: 10 articles (01/2021 - 05/2002)
5.	Nagakura, Yukinori: 8 articles (01/2022 - 11/2009)
6.	Fachinetto, Roselei: 8 articles (12/2020 - 12/2004)
7.	Bhatti, Rajbir: 7 articles (05/2021 - 01/2019)
8.	Machado-de-Ávila, Ricardo Andrez: 6 articles (02/2022 - 10/2019)
9.	Scussel, Rahisa: 6 articles (02/2022 - 10/2019)
10.	Kaur, Anudeep: 6 articles (05/2021 - 01/2019)

Related Diseases

1.	Pain (Aches) 11/01/2020 - "In comparison to reserpine group, the extract treatment attenuated pain as shown by significant increase in paw withdrawal threshold against mechanical stimuli (P < 0.05), improved motor ability indicated by increase in fall-off time in inclined plane test (P < 0.05), improved locomotion indicated by increased square crossings in open field test (P < 0.05), and improved cognition as shown by significant reduction in time to reach platform in Morris water maze test and passive avoidance task test (P < 0.05). " 07/01/2017 - "A previous study by our group found that 100-Hz electro-acupuncture (EA), but not 2-, 50- and 2/100-Hz EA, was effective against the reserpine-induced pain-depression dyad. " 09/05/2019 - "The purpose of this study was to investigate the participation of spinal α5-GABAA receptors in the reserpine-induced pain model. " 01/01/2018 - "In view of develop more effective treatments to comorbid pain and depression, the purpose of this study was to evaluate the behavioral and biochemical effects of PSAP on reserpine induced pain-depression dyad model in mice as well to analyze the interaction of PSAP with specific targets by molecular docking analysis. " 04/01/2016 - "In present study, we investigated the anti-depression activities in the mouse model of reserpine-induced pain-depression dyad. "
2.	Hypertension (High Blood Pressure) 01/01/2023 - "The experiments found that the drug reserpine, which was previously approved to treat high blood pressure, also helped photoreceptors to survive in the diseased organoids. " 10/01/1967 - "[On the efficacy of reserpine in hypertension of the lesser circulation]." 02/01/1997 - "German Reserpine in Hypertension Study Group." 09/28/1956 - "[Studies in capillary microscopy relative to the effects of reserpine on blood circulation in hypertension]." 10/29/1955 - "Hypertension treated with Rauwolfia serpentina (whole root) and with reserpine; controlled study disclosing occasional severe depression."
3.	Tardive Dyskinesia 06/01/2002 - "While reserpine-induced oral movements (OM), an animal model of tardive dyskinesia, are more persistent in old than in adult rats, old animals present spontaneous OM, which are phenomenologically similar to those presented by reserpine-treated adult rats. " 10/01/1997 - "1- The effects of monosialoganglioside GM1 were studied on a new model of tardive dyskinesia, i.e., the frequency of spontaneous tongue protrusions in rats repeatedly treated with reserpine. " 05/01/1984 - "Reserpine and tardive dyskinesia." 08/01/1983 - "Questioning reserpine's adverse effect on tardive dyskinesia." 02/01/1983 - "The authors used reserpine to treat a case of tardive dyskinesia. "
4.	Parkinson Disease (Parkinson's Disease) 01/01/2021 - "Reserpine (RES) is an irreversible inhibitor of VMAT2 used to study Parkinson's disease (PD) and screening for antiparkinsonian treatments in rodents. " 01/01/2020 - "The systemic administration of low reserpine (RES) doses (0.1-1.0 mg/kg) has been proposed as a valuable rat model for the study of non-motor symptoms of Parkinson's disease (PD). " 01/01/2017 - "Reserpine is an irreversible inhibitor of vesicular monoamine transporter-2 (VMAT2) used to study Parkinson's disease (PD) and screening for antiparkinsonian treatments in rodents. " 01/01/2021 - "Female Rats Are Resistant to Cognitive, Motor and Dopaminergic Deficits in the Reserpine-Induced Progressive Model of Parkinson's Disease." 01/01/2021 - "Changes in the mesocorticolimbic pathway after low dose reserpine-treatment in Wistar and Spontaneously Hypertensive Rats (SHR): Implications for cognitive deficits in a progressive animal model for Parkinson's disease."
5.	Fibromyalgia (Fibrositis) 10/01/2022 - "Broad-spectrum cannabis oil ameliorates reserpine-induced fibromyalgia model in mice." 02/01/2021 - "In the present study, Swiss mice were treated with reserpine (0.25 mg/kg, s.c.) over three consecutive days, in order to reproduce the pathogenic process of fibromyalgia. " 11/01/2015 - "The present study aims at a validation of the reserpine model of fibromyalgia. " 11/01/2009 - "In the present study, we have established a fibromyalgia animal model by utilizing a never-before-published pharmacological effect of reserpine. " 10/01/2022 - "In summary, broad-spectrum cannabis oil is an effective alternative to reverse the reserpine-induced fibromyalgia model."

Related Drugs and Biologics

1.	Serotonin (5 Hydroxytryptamine)
2.	Chlorpromazine (Thorazine)
3.	Dopamine (Intropin)
4.	Antipsychotic Agents (Antipsychotics)
5.	Hydrochlorothiazide (Esidrix)
6.	Hydralazine (Apresoline)
7.	Levodopa (L Dopa)
8.	Adrenergic Receptors (Adrenergic Receptor)
9.	Thiazides
10.	Haloperidol (Haldol)

Related Therapies and Procedures

1.	Therapeutics
2.	Intravenous Infusions
3.	Adrenalectomy
4.	Pituitary Irradiation
5.	Intravenous Injections