Chymosin (Rennin)

The predominant milk-clotting enzyme from the true stomach or abomasum of the suckling calf. It is secreted as an inactive precursor called prorennin and converted in the acid environment of the stomach to the active enzyme. EC 3.4.23.4.

Also Known As:

Networked: 140 relevant articles (6 outcomes, 14 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Wang, Jing: 2 articles (07/2015 - 09/2012)
2.	Guo, Juan: 2 articles (10/2014 - 08/2007)
3.	Chen, Chang Xun: 2 articles (10/2014 - 10/2010)
4.	Gao, Jian Ping: 2 articles (10/2014 - 10/2010)
5.	Racki, S: 2 articles (01/2014 - 01/2014)
6.	Milic, S: 2 articles (01/2014 - 01/2014)
7.	Mikolasevic, I: 2 articles (01/2014 - 01/2014)
8.	Tsyv'ian, P B: 2 articles (01/2013 - 12/2004)
9.	Wang, Yan: 2 articles (09/2012 - 08/2004)
10.	Skvortsova, V I: 2 articles (03/2012 - 01/2012)

Related Diseases

1.	Hypertension (High Blood Pressure) 09/01/2009 - "Combination therapy based on rennin-angiotenzin system blockade: ACEi with a CCB, ACEi with a diuretic or angiotenzin receptor blocker (AT1) with a diuretic as a first-line treatment of the stage 2 hypertension might lead to significantly better control of blood pressure than monotherapy." 10/01/2013 - "Hypertension with low Plasma Rennin Activity (PRA), although rare, is important as it is often familial and is associated with single gene disorders (monogenic). " 01/01/2013 - "Other intensive investigations did not show any other origin for rennin secretion or hypertension in this patient. " 03/01/2007 - "The clinical laboratory can help in this regard by separating primary hypertension cases (high plasma rennin activity and low plasma rennin activity types) from those of secondary and mendelian types of hypertension. " 08/01/2004 - "The activity of rennin-angiotension system is higher in the OSAHS may have contribute to OSAHS-induced hypertension."
2.	Diabetic Nephropathies (Diabetic Nephropathy) 05/04/2003 - "We use diabetic nephropathy to demonstrate the clinical benefits that can be attained by administering inhibitors of the rennin-angiotensin system in more and more progressive stages of the diabetic "renal continuum". " 11/01/2010 - "1. The aim of the present study was to investigate whether or not pitavastatin ameliorates diabetic nephropathy and if inhibition of the rennin-angiotensin-aldosterone system (RAAS) is associated with any renoprotective effects. " 01/01/2012 - "diabetic and non-diabetic nephropathy Nephroprotective properties of the blockers of rennin-angiotensin-aldosteron system and other antiadrenergic drugs, diuretics, hypolipidemic, antianemic and hypouricemic drugs, active metabolites of vitamin D, metphormine and glytasones are reviewed. " 03/01/2015 - "Inhibition of the rennin-angiotensin system (RAS) could reduce insulin resistance in patients with hypertension and diabetic kidney disease (DKD), but whether the effect of losartan on insulin resistance is associated with reduction of oxidative stress and enhancement of insulin signaling transduction has not been fully elucidated. "
3.	Cardiovascular Diseases (Cardiovascular Disease) 09/15/2010 - "In this way, chronic administration of t-RESV may reduce the systemic inflammatory response associated with the activation of the rennin-angiotensin system, thereby decreasing the risk of further cardiovascular disease." 04/01/2007 - "[Does the rennin inhibitor aliskiren offer promising novel opportunities in the treatment of cardiovascular diseases?]." 09/01/2012 - "Therefore, we (i) review pathways through which high salt intake exerts damaging effects, (ii) provide an assessment of recent observational studies linking dietary salt intake to the progression of renal and cardiovascular disease and (iii) discuss the interaction between salt intake and rennin-angiotensin-aldosterone-system inhibitors, i.e. " 09/01/2010 - "However, intensified intervention involving other CVD risk factors like hypertension and dyslepidemia and interception of the rennin-angiotensin-aldosterone system in patients with type 2 diabetes have been shown to be associated with significant reduction in the risk for renal disease progression that was paralleled by a significant reduction in cardiovascular disease burden."
4.	Sleep Deprivation 12/01/2014 - "The changes of serum rennin and cortisol in the lower mental resilience subgroup were significantly greater (P < 0.05); problem-solving skill and willpower were the leading influence factors for the increases of serum rennin and cortisol respectively induced by sleep deprivation. " 12/01/2014 - "The aim of this study was to investigate the effects of mental resilience on the changes of serum rennin, angiotensin, and cortisol level induced by sleep deprivation in servicemen. " 12/01/2014 - "As hypothesized, serum rennin, angiotensin II, and cortisol level of the participants after sleep deprivation were significantly higher than those before (P < 0.05). "
5.	Chronic Kidney Failure (Chronic Renal Failure) 02/01/2006 - "Based on these and other data, antioxidant therapy and blockade of rennin-angiotensin system may prove beneficial for the prevention of end stage renal disease caused by hyperoxaluria and CaOx crystal deposition." 07/01/1998 - "Intense work of the remaining nephrons in chronic renal failure is under the high level controls of the group of hormones, among them are rennin-angiotensin system, arginine-vasopressin and atrial natriuretic peptide playing very important and particular roles. "

Related Drugs and Biologics

1.	Angiotensins
2.	Aldosterone
3.	Hydrocortisone (Cortisol)
4.	pitavastatin (itavastatin)
5.	Nitric Oxide (Nitrogen Monoxide)
6.	Adenosine
7.	eplerenone (Inspra)
8.	Streptozocin (Streptozotocin)
9.	Oxygen
10.	Electrolytes

Related Therapies and Procedures

1.	Sodium-Restricted Diet (Diet, Sodium Restricted)
2.	Subcutaneous Infusions
3.	Homologous Transplantation (Allograft)
4.	Ligation
5.	Decompression