Spontaneous Remission

01/01/2005 - "Evolution was marked by the spontaneous regression of the plaque on the face and remission of the other two plaques after local treatment with chloromethin and topical corticosteroids. "
05/15/2018 - "Although spontaneous regression occurs, sometimes treatment is required and alternatives to corticosteroids should be considered to reduce side effects. "
01/01/2018 - "Corticosteroids are considered the treatment of choice, but the disease exhibits a tendency towards spontaneous regression. "
06/01/2007 - "We describe the case of a 31-year-old woman with a 3-year history of persistent ALHE, located on the tragus of her right ear, with no sign of spontaneous regression over a period of 3-6 months and refractory to intralesional corticosteroids. "
08/01/2003 - "Higher p40 levels were also found in the BALF from sarcoid patients who required corticosteroid treatment compared with patients with spontaneous regression (3.51 +/- 3.83 vs. 2.01 +/- 3.43, p = 0.03). "

11/01/2010 - "Following immunomodulator discontinuation, the patient experienced spontaneous regression of his skin lesions. "
01/01/2009 - "Among the numerous proposed mechanisms of spontaneous regression for HCC, immunological factors, which have yet to be fully understood, may have the most important roles in this rare phenomenon. "
01/01/2018 - "In the neonatal period, the immune system is weak, but spontaneous regression and good outcomes occur for some cancers, suggesting that non-immune factors are effective in controlling cancer. "
01/01/1976 - "Relationship of causative factors in spontaneous regression of cancer to immunologic factors possibly effective in cancer."
05/01/2022 - "Most other cases of spontaneous regression of lung cancer hint at the involvement of immunological factors, and this case possibly involves a combination of mechanical and local immunological factors. "

07/01/2017 - "Traumatic tympanic membrane perforations (TMPs) tend to spontaneous healing, however, large TMPs usually fail to healing. "
08/01/2014 - "These observations suggest that different mechanisms may be involved in spontaneous healing of dry and wet traumatic TMPs in humans, thereby resulting in differences in healing time and healing outcome."
08/01/2014 - "This prospective study aimed to assess the spontaneous healing mechanisms of human dry and endogenous wet traumatic tympanic membrane perforations (TMPs). "
12/01/2012 - "To characterize the otoendoscopic features of traumatic tympanic membrane perforations (TMPs) with outward-migrating epithelium at the perforation edges and to evaluate the spontaneous healing outcome of this type of perforation. "
07/01/2017 - "This study investigated the influence of the degree of bleeding from the remnant eardrum on the spontaneous healing of human traumatic tympanic membrane perforations (TMPs). "

11/01/2018 - "Spontaneous regression of a renal mass and multiple lung nodules after methotrexate cessation."
01/01/2016 - "Methotrexate withdrawal resulted in spontaneous regression. "
01/01/2022 - "Treatment for RA was resumed in 138 patients after spontaneous regression of LPD after the discontinuation of methotrexate and in 52 patients after chemotherapy for LPD (persistent-LPD). "
02/01/2021 - "Although spontaneous remission occurred after methotrexate discontinuation, she developed HHL presenting as a solitary hepatic mass without lymphadenopathy 3 years after spontaneous regression. "
01/01/2022 - "In this study, we investigated the usefulness of FDG-PET/CT for predicting spontaneous regression in methotrexate-associated lymphoproliferative disorder (MTX-LPD). "

01/01/2018 - "Conclusions: Asymptomatic nodules should be observed for spontaneous regression or treated with nonsurgical techniques such as chemotherapeutic or steroid injection. "
01/01/1999 - "Prompt steroid treatment can produce spontaneous regression in such cases."
06/01/1986 - "All patients either responded to steroids or had spontaneous regression of radiographic abnormalities supporting the presumed diagnosis of treatment related changes. "
01/01/2022 - "We describe a rare case of an intracranial GCT in the thalamus of an adult that showed spontaneous regression and recurrence after steroid therapy. "
09/01/2000 - "Despite the possibility of spontaneous regression, systemic steroids may be beneficial in reducing the development of interstitial fibrosis."

01/01/2011 - "The healing rate varied slightly: 90.7% vs 92.3% in spontaneous healing group, 98.2% vs 97.4% in EGF via Gelfoam patching group, and 96.5% vs 100% in edge-approximation plus Gelfoam patching group. "
03/01/2019 - "Topical application of EGF improved the closure rate and shortened the closure time of human subacute TMPs compared with spontaneous healing, the stripping of the perforation edge was unnecessary. "
12/01/2019 - "The closure times, closure rates, and hearing gain were compared among the groups at 6 months.Results: The mean closure time was 10.20 ± 5.13 days in the low-dosage EGF group, 14.39 ± 6.20 days in the high-dosage EGF group, and 33.17 ± 16.37 days in the spontaneous healing group; the difference was significant (p < .001).Conclusions: Daily application of EGF shortened the closure time of traumatic TMPs compared with those that healed spontaneously. "
12/01/2019 - " and materials: Patients with traumatic TMPs were first randomly assigned to low-dose EGF, high-dose EGF, and spontaneous healing groups. "
12/01/2018 - "As compared with spontaneous healing, daily application of EGF and gelatin sponge patching reduced the closure time of traumatic tympanic membrane perforations. "

09/01/2019 - "The use of bone substitute material led to significantly greater horizontal dimensions amounting to 3.3 mm (SD = 0.67; test 1) and 3.5 mm (SD = 0.72; test 2) compared to spontaneous healing (1.7 mm, SD = 0.23) at 16 weeks of healing (p < 0.0001). "
09/01/2019 - "The extraction sites were randomly assigned either to a ridge preservation procedure (alloplastic bone substitute material (two test groups)) or to spontaneous healing (control group). "
09/01/2019 - "To investigate whether one of two synthetic bone substitute materials used for ridge preservation in the extraction sockets with buccal dehiscence defects was superior regarding new bone formation and ridge preservation and to compare it to sites left for spontaneous healing. "
02/01/2023 - "Eleven studies fulfilled the inclusion criteria and were included for descriptive analysis, with a total of 215 patients, and 337 alveoli preserved by APD, spontaneous healing (blood clot), or other bone substitutes, obtaining comparatively less vertical and horizontal resorption when APD was used. "
01/01/2021 - "After single tooth extraction in the maxillary incisor/premolar area, patients were randomly allocated to one of the following groups: (a) ridge preservation with a xenogeneic bone substitute covered with a collagen matrix (CM-group), (b) ridge preservation with a xenogeneic bone substitute covered with a free palatal graft (PG-group) or (c) spontaneous healing (control). "

06/01/2013 - "Spontaneous regression of metastatic papillary renal cell cancer after cessation of treatment with sorafenib."
04/01/2023 - "A recent randomized trial demonstrated that sorafenib improved progression free survival (PFS) in patients with desmoid tumors despite many patients experiencing stable disease or spontaneous regression without treatment. "
06/01/2013 - "Durable spontaneous regression of lung metastases from renal cell carcinoma after incomplete use of multiple kinase inhibitor sorafenib."

01/01/2017 - "Spontaneous regression of malignant melanoma - is it based on the interplay between host immune system and melanoma antigens?"
09/01/2013 - "The genetic aberrations of these tumours closely resemble those of cutaneous melanomas, and therefore are suggestive of spontaneous regressions of the primary tumours.3.Both primary tumours and metastases often have brisk lymphocytic infiltrates, a phenomenon that is correlated with better outcome.4.Studies of isolates of these tumour-infiltrating T lymphocytes have revealed that a proportion of these cells recognise melanoma antigens.5.Melanomas respond to immunotherapy. "

09/01/2023 - "This study suggested that both FGF2 and OFLX significantly shortened the mean closure time and improved the closure rate compared with spontaneous healing for repairing large traumatic perforations, while the healing outcome wasn't significantly different among FGF2 and OFLX groups."
09/01/2023 - "The mean ABG was 10.37 ± 2.51 dB for the FGF2 group, 11.01 ± 1.31 dB for the OFLX group, and 10.86 ± 1.94 dB for the spontaneous healing group, no significant difference was found among three groups (P > 0.05). "
09/01/2023 - "The mean closure time was 9.69 ± 2.46 days in the FGF2 group, 9.45 ± 2.32 days in the OFLX group, and 30.94 ± 8.95 days in the spontaneous healing group (P < 0.01). "
09/01/2023 - "A total of 75 traumatic large perforations with >1/4 of TM were randomly divided into FGF2 (n = 25), OFLX (n = 25), and spontaneous healing (n = 25) groups. "
06/01/2023 - "Additionally, new periodontal tissues induced by FGF-2 and CO3Ap may follow a maturation process similar to that formed by spontaneous healing. "

08/01/1998 - "Complete spontaneous regression occurred over 5 months without any form of conventional or alternative therapy, and the patient remains disease-free 3 years after diagnosis. "
04/01/2023 - "Spontaneous healing of iatrogenic left atrial dissection: a rare complication of MitraClip therapy."
09/01/2022 - "Periods of prolonged stability and spontaneous regression in the absence of therapy in some patients has prompted wider adoption of an upfront active surveillance approach in the appropriate setting. "
03/05/2022 - "The aim of this review is to outline the changes in the immune microenvironment in spontaneous regression, persistence, and responses to (immuno)therapy. "
01/01/2021 - "Of 65 initially observed malformations, 8 (12%) subsequently had invasive treatment, 36 (58%) had spontaneous regression, and 21 (32%) elected for no invasive therapy. "

11/01/1984 - "Spontaneous regression was never observed but in two patients a prolonged remission was achieved by chemotherapy. "
01/01/2022 - "These patients were divided into those who showed spontaneous regression (SR group: ten patients) and those who received chemotherapy after discontinuation of MTX (CTx group: ten patients). "
11/01/2021 - "The chemotherapy group had significantly less RA relapse than the spontaneous regression group (p = .041). "
01/01/2021 - "Owing to the spontaneous regression observed in some patients, uniform chemotherapy is not recommended. "
01/28/2020 - "Chemotherapy was performed despite the spontaneous regression of lung lesions. "

06/12/1981 - "Compared with the spontaneous healing process of the apoplectic insult by means of conservative therapy this demonstrates on average a smaller early mortality with a simultaneous higher remission rate of the neurological findings of maximally 70% compared with 48%. "
01/01/2022 - "The study enrolled 190 eligible fetuses, including 94 cases of spontaneous regression, 33 cases of conservative management and 63 cases of surgical intervention. "
01/01/2021 - "Earlier studies have demonstrated that conservative treatment of OCD is appropriate for patients with an open capitellar growth plate from the standpoint that spontaneous healing can be expected. "
01/16/2023 - "However, more patients achieved spontaneous healing in the low-risk group than the high-risk group among the conservative treatment patients (86.4% vs. 33.3%, p < 0.05). "
07/01/2022 - "Conservative management and repeat imaging are appropriate to monitor spontaneous regression. "

02/01/2018 - "Given that the spontaneous regression of CIN2/3 is 20-25% at 6 months, targeted immunotherapy occurs an additional value, which never reaches 50%, with one trial an exception to this. "
01/01/2018 - "MCC has long been appreciated to be immunogenic, with reports of spontaneous regression and responsiveness to immunotherapy. "
01/01/2018 - "Therefore, in this review, we provide a thorough overview of how different modes of cell death and treatment strategies, such as immunotherapy or spontaneous regression, are or can be applied for NB elimination. "
07/01/2005 - "Bio-immunotherapy seems to simulate a spontaneous healing process."
01/31/2023 - "Suboptimal tumor induction rates and potential spontaneous regression during tumor implantation procedures discouraged the use of the N1-S1 HCC model in IO-based immunotherapies. "

06/01/2018 - "Spontaneous regression occurred in 13 of 15 cases (87%); the other two cases (13%) achieved complete remission after treatment. "
02/01/2006 - "Of the remaining 33 dogs, five (15.2%) presented spontaneous regression of the lesions, 26 (78.8%) were cured after treatment, and two (6%) continue to be treated. "
11/05/2009 - "Spontaneous regression occurs in less than 1.5% of patients, and the rate of recurrence after treatment is high. "
05/31/1934 - "A parallelism was observed between the blood cell changes of the experimental disease after spontaneous regression of lesions, and the cell changes in the human disease after treatment. "
01/01/1995 - "During the unpredictable clinical course, recurrence after treatment as well as spontaneous regression is observed. "