Virus Receptors

Specific molecular components of the cell capable of recognizing and interacting with a virus, and which, after binding it, are capable of generating some signal that initiates the chain of events leading to the biological response.

Also Known As:

Receptors, Virus; Attachment Factor, Virus; Attachment Factors, Virus; Attachment Receptor, Virus; Attachment Receptors, Virus; Entry Receptor, Viral; Entry Receptor, Virus; Entry Receptors, Viral; Entry Receptors, Virus; Receptor, Viral Entry; Receptor, Virus; Receptor, Virus Attachment; Receptor, Virus Entry; Receptors, Viral Entry; Receptors, Virus Attachment; Receptors, Virus Entry; Viral Entry Receptor; Viral Entry Receptors; Virus Attachment Factor; Virus Attachment Factors; Virus Attachment Receptor; Virus Attachment Receptors; Virus Entry Receptor; Virus Entry Receptors; Virus Receptor

Networked: 342 relevant articles (9 outcomes, 16 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Membrane Proteins: 10078
    - Cell Surface Receptors: 2125
      - Virus Receptors: 342
        adenovirus receptor: 352
        poliovirus receptor: 141
        Coxsackie and Adenovirus Receptor-Like Membrane Protein: 138
        Complement 3d Receptors: 79
        Member 14 Tumor Necrosis Factor Receptors: 70
        Hepatitis A Virus Cellular Receptor 2: 38
        Bacteriophage Receptors: 35
        Tva receptor: 33
        Niemann-Pick C1 Protein: 32
        Coronavirus Receptors: 20
        Hepatitis A Virus Cellular Receptor 1: 19
        HIV Receptors: 18
        gibbon ape leukemia virus receptor: 13
        Xenotropic and Polytropic Retrovirus Receptor: 11
        CXCR6 Receptors: 8
        maltoporins: 6
        ecotropic murine leukemia virus receptor: 5
        Bos taurus BLVR protein: 4
        feline leukemia virus receptor: 4
        simplexvirus receptor: 3
        alphavirus receptor: 2
        bovine viral diarrhea virus receptor: 2
        cytomegalovirus receptor: 2
        parvovirus B19 receptor: 2
        coxsackievirus B receptor: 1
        dengue virus receptor: 1
        hCAR-EGFP fusion receptor: 1
        HIg receptor: 1
        HTLV-I receptor: 1
        reovirus type 3 receptor: 1
        Bacteroides fragilis BactA protein
        Bacteroides fragilis BactB protein
        choleraphage phi 149 receptor
        E coli Tsx protein
        echovirus 11 receptor
        feline leukemia virus FeLIX protein
        gp57-67 binding protein
        HN protein receptor
        human FAM111A protein
        human FAM89B protein
        human FLVCR1 protein
        human FLVCR2 protein
        human hepatitis B virus-binding protein
        human herpesvirus 6 U51 protein
        human MTVR2 protein
        mouse Fam89b protein
        mouse Flvcr1 protein
        mouse LSECtin protein
        pixuna virus receptor
        Sendai virus virus fusion protein receptor
        VESPR semaphorin receptor
        zebrafish CXADR protein

Experts

1.	Fechner, Henry: 4 articles (01/2020 - 12/2009)
2.	Miller, A Dusty: 4 articles (09/2005 - 04/2005)
3.	Tseng, Chien-Te K: 3 articles (09/2021 - 02/2007)
4.	Pinkert, Sandra: 3 articles (01/2020 - 12/2009)
5.	Kawaoka, Yoshihiro: 3 articles (01/2019 - 02/2006)
6.	Chandran, Bala: 3 articles (11/2017 - 03/2010)
7.	Suzuki, Yasuo: 3 articles (01/2011 - 02/2006)
8.	Clark, Natasha M: 2 articles (01/2022 - 09/2021)
9.	Connor, Joseph P: 2 articles (01/2022 - 09/2021)
10.	Evans, David T: 2 articles (01/2022 - 09/2021)

Related Diseases

1.	Virus Diseases (Viral Diseases) 10/01/2005 - "The rapid progress in molecular biologic techniques also helped resolve many virologic puzzles and yielded highly valuable data hitherto unavailable, such as characterization of virus receptors, the genetic basis of vertebrate resistance to viral infection, and phylogenetic evidence of the history of host range shifts in arboviruses. " 12/01/2018 - "In this study, to understand the relationship between BmBDV and the putative virus receptor, we performed expression analysis of +nsd-2 (allele of nsd-2; susceptibility gene) after virus infection. " 09/19/2023 - "In this review, we describe factors that mediate the high susceptibility of astrocytes to viral infection and replication, including the anatomic localization of astrocytes, morphology, expression of viral entry receptors, and various forms of autophagy." 01/01/2023 - "IMPORTANCE Virus receptors are known to mediate virus attachment and further lead to virus infection of the host cells. " 11/22/2022 - "Virus-receptor interactions are poorly understood at the nanoscale, yet they present an attractive target for the design of drugs and for the illumination of viral infection and pathogenesis. "
2.	Infections 01/01/2021 - "Several studies have proposed that kidney cells, including the podocytes, might be at risk of direct infection by SARS-CoV-2, as high levels of ACE2, the virus receptor, are expressed on the membrane of such cells. " 04/01/2014 - "The structures and conclusions in this study are original and raise interesting findings regarding virus-receptor interactions and the order of key events early in infection." 06/01/2000 - "The model constructed and the interaction mode reported in the present study are useful in further understanding the molecular mechanism of receptor-virus recognition and designing new inhibitors of HIV-1 infection." 09/19/2023 - "These properties, together with the expression of various and numerous viral entry receptors, a relatively high rate of endocytosis, and morphological plasticity of intracellular organelles, render astrocytes important target cells in neurotropic infections. " 01/01/2023 - "To elucidate how NgR1 mediates cell binding and entry of reovirus, we defined the affinity of interaction between virus and receptor, determined the structure of the virus-receptor complex, and identified residues in the receptor required for virus binding and infection. "
3.	Cicatrix (Scar) 06/01/2015 - "Thus, sCAR-Fc virus receptor trap may be a promising novel therapeutic for treatment of Ad infections." 01/01/2020 - "Previously, we and others found that the soluble virus receptor trap sCAR-Fc strongly attenuates CVB3 infection in mice. " 06/01/2015 - "Here, we analyzed the potential of a virus receptor trap based on a soluble coxsackievirus and Ad receptor (sCAR) for inhibition of Ad infection. " 01/01/2020 - "These data demonstrate that during sCAR-Fc exposure, CVB3 can develop resistance against sCAR-Fc by single-amino-acid exchanges within the virus-receptor binding site, which, however, come at the expense of viral fitness.IMPORTANCE The emergence of resistant viruses is one of the most frequent obstacles preventing successful therapy of viral infections, representing a significant threat to human health. " 08/01/2015 - "In the present in vitro study, we examined whether the efficiency of an RNAi-based anti-adenoviral therapy can be further increased by combination with a virus receptor trap sCAR-Fc and with the antiviral drug cidofovir. "
4.	Myocarditis (Carditis) 08/01/2006 - "Furthermore, it consists exclusively of human components, and we demonstrated that this soluble virus receptor trap may be used as a potential candidate for a novel therapeutic agent for the treatment of acute viral myocarditis during the viremic phase." 02/15/2015 - "The potential of a combination treatment consisting of a proteinaceous virus receptor trap and an RNA interference-based component to prevent CVB3-induced myocarditis was investigated. " 08/01/2006 - "Virus receptor trap neutralizes coxsackievirus in experimental murine viral myocarditis." 01/01/2006 - "Anti-CD8 depletion of CD8+ T cells protects infected BALB/c mice but aggravates disease in infected DAF-/- animals, indicating that the immunopathogenicity of viral myocarditis differs in the absence of the DAF virus receptor." 05/01/2005 - "Age-matched female mice show little myocarditis due to decreased virus receptor expression on cardiac cells. "
5.	Superinfection 09/01/2015 - "HIV-1 Nef downregulates the viral entry receptor CD4 as well as the coreceptors CCR5 and CXCR4 from the surface of HIV-infected cells, and this leads to promotion of viral replication through superinfection resistance and other mechanisms. " 07/05/2003 - "Downregulation of virus receptors on the cell surface is considered to be important in preventing superinfection. " 08/01/1999 - "The resistance of cured cells to superinfection with picornaviruses seemed attributable neither to interferon action nor to destruction or blockade of virus receptors but more likely to the consumption of some host factor(s) involved in the expression of early viral functions during the original infection." 01/01/2020 - "Furthermore, bat cells that were persistently infected with ΔORF5 MERS-CoV were resistant to superinfection by wildtype virus, likely due to reduced levels of the virus receptor, dipeptidyl peptidase 4 (DPP4) and higher basal levels of interferon in these cells. "

Related Drugs and Biologics

1.	Vaccines
2.	Immunoglobulin G (IgG)
3.	Proteins (Proteins, Gene)
4.	Peptides (Polypeptides)
5.	Interferons
6.	Amino Acids
7.	Angiotensin-Converting Enzyme 2
8.	Antiviral Agents (Antivirals)
9.	Lectins
10.	Monoclonal Antibodies

Related Therapies and Procedures

1.	Therapeutics
2.	Intramuscular Injections