Somatotropin Receptors (Growth Hormone Receptor)

Cell surface proteins that bind GROWTH HORMONE with high affinity and trigger intracellular changes influencing the behavior of cells. Activation of growth hormone receptors regulates amino acid transport through cell membranes, RNA translation to protein, DNA transcription, and protein and amino acid catabolism in many cell types. Many of these effects are mediated indirectly through stimulation of the release of somatomedins.

Also Known As:

Networked: 298 relevant articles (6 outcomes, 30 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Trainer, P J: 8 articles (10/2002 - 04/2000)
2.	Laron, Zvi: 6 articles (05/2014 - 04/2003)
3.	Parkinson, C: 6 articles (10/2002 - 04/2000)
4.	Besser, G M: 6 articles (03/2002 - 04/2000)
5.	Kopchick, John J: 5 articles (02/2015 - 09/2003)
6.	Chen, Che: 5 articles (07/2014 - 09/2004)
7.	Xu, Zhe: 5 articles (07/2014 - 09/2004)
8.	Kruslin, Bozo: 5 articles (06/2013 - 07/2003)
9.	Friend, K E: 5 articles (11/2004 - 04/2000)
10.	Drake, W M: 5 articles (03/2002 - 04/2000)

Related Diseases

1.	Acromegaly 09/01/2015 - "This study investigated the association between the frequency of growth hormone receptor (GHR) exon 3 polymorphism (exon 3 deletion; d3-GHR) and metabolic factors in patients with acromegaly in Korea. " 09/01/2015 - "Association between the Growth Hormone Receptor Exon 3 Polymorphism and Metabolic Factors in Korean Patients with Acromegaly." 05/01/2011 - "[Growth hormone receptor antagonist in the treatment of acromegaly]." 12/01/2009 - "The exon-3 deleted growth hormone receptor polymorphism predisposes to long-term complications of acromegaly." 09/01/2008 - "Clinical and biochemical impact of the d3 growth hormone receptor genotype in acromegaly."
2.	Dwarfism 01/01/2008 - "Novel splice site mutation in the growth hormone receptor gene in Turkish patients with Laron-type dwarfism." 04/01/2003 - "Laron-type dwarfism is an autosomal recessive disorder caused by deletions or mutations of the growth hormone receptor gene. " 11/01/1999 - "A novel phenotype for Lardon dwarfism in miniature Bos indicus cattle suggests that the expression of growth hormone receptor 1A in liver is required for normal growth." 05/15/1994 - "[Growth hormone receptor and dwarfism]." 11/15/1990 - "We describe an inbred population with a high incidence of growth hormone-receptor deficiency resulting in a clinical picture resembling Laron-type dwarfism but differing principally in showing a marked predominance of affected females. "
3.	Pituitary Neoplasms (Pituitary Adenoma) 05/01/2004 - "Growth hormone receptor expression and function in pituitary adenomas." 08/01/2007 - "A growth hormone receptor mutation impairs growth hormone autofeedback signaling in pituitary tumors." 11/01/2003 - "Ghrelin and its receptor, growth hormone secretagogue (GHS) receptor (GHSR), are expressed in the normal pituitary gland and various types of pituitary adenoma. " 04/01/2005 - "Growth hormone receptor mRNA expression in non-functioning and somatotroph pituitary adenomas: implications for growth hormone substitution therapy?" 11/01/2003 - "Somatostatin analogues and pegvisomant, a novel growth hormone-receptor antagonist, results in a reduction of serum IGF-I levels and clinical improvement in patients suffering from pituitary adenoma. "
4.	Gigantism 03/01/2013 - "Pituitary gigantism treated successfully with the growth hormone receptor antagonist, pegvisomant." 08/01/2008 - "Treatment of pituitary gigantism with the growth hormone receptor antagonist pegvisomant." 09/01/2010 - "Excessive activation of the growth hormone receptor by circulating growth hormone results in gigantism and acromegaly, whereas cell transformation and cancer can occur in response to autocrine activation of the receptor. "
5.	Cataract (Cataracts) 09/01/2005 - "The 5th model, growth hormone receptor knockout (GHR-/-) mice, also demonstrated a significant reduction in age-related cataract development, as well as dwarfism. "

Related Drugs and Biologics

1.	Somatostatin (Somatotropin Release-Inhibiting Factor)
2.	pegvisomant
3.	Dopamine Agonists (Dopamine Agonist)
4.	Insulin-Like Growth Factor I (IGF-1)
5.	Carbon Monoxide
6.	Growth Hormone (Somatotropin)
7.	Insulin (Novolin)
8.	Messenger RNA (mRNA)
9.	Insulin-Like Growth Factor Binding Proteins
10.	Ribonucleases (Ribonuclease)

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Surgical Instruments (Clip)
3.	Radiotherapy
4.	Heterologous Transplantation (Xenotransplantation)
5.	Enteral Nutrition (Feeding, Tube)