Prostaglandin Receptors (Prostaglandin Receptor)

Cell surface receptors that bind prostaglandins with high affinity and trigger intracellular changes which influence the behavior of cells. Prostaglandin receptor subtypes have been tentatively named according to their relative affinities for the endogenous prostaglandins. They include those which prefer prostaglandin D2 (DP receptors), prostaglandin E2 (EP1, EP2, and EP3 receptors), prostaglandin F2-alpha (FP receptors), and prostacyclin (IP receptors).

Also Known As:

Networked: 102 relevant articles (3 outcomes, 6 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Narumiya, Shuh: 8 articles (05/2011 - 04/2002)
2.	Sugimoto, Yukihiko: 4 articles (01/2012 - 04/2002)
3.	Jiang, Jianxiong: 3 articles (07/2013 - 02/2013)
4.	Andreasson, Katrin: 3 articles (11/2011 - 06/2007)
5.	Breyer, Richard M: 3 articles (09/2007 - 04/2002)
6.	Müller, Stefan C: 2 articles (01/2014 - 01/2012)
7.	Ellinger, Jörg: 2 articles (01/2014 - 01/2012)
8.	Dingledine, Ray: 2 articles (07/2013 - 02/2013)
9.	Wang, Qian: 2 articles (11/2011 - 06/2007)
10.	Liang, Xibin: 2 articles (11/2011 - 06/2007)

Related Diseases

1.	Anoxia (Hypoxia) 06/01/2010 - "Recent studies in models of in vitro excitotoxicity or hypoxia demonstrate that certain prostaglandin receptors mediate toxic effects, but a large number appear to mediate paradoxically protective effects. " 01/01/2012 - "Due to the number of prostaglandin receptors, prostaglandin-dependent signaling can function either to promote neuronal survival or injury following acute excitotoxicity, hypoxia, and stress induced by ICH. " 08/01/2015 - "Hypoxia-induced vasorelaxation of porcine retinal arterioles is mediated by inducible NOS and stimulation of EP4 receptors acting through separate pathways, but mechanisms unrelated to the studied prostaglandin receptors and NOS products are also involved."
2.	Neoplasms (Cancer) 03/01/2014 - "In vivo expression of prostaglandin receptor E-prostanoid 4 (EP4) was analyzed in a retrospective cohort of pancreatic tumors using a tissue microarray. " 02/01/2013 - "Our results suggest the involvement of prostaglandin receptor EP2 in cancer cell proliferation and invasion possibly via its inflammatory actions, and indicate that selective blockade of the PGE(2)-EP2 signaling pathway via small molecule antagonists might represent a novel therapy for tumorigenesis." 05/15/2009 - "We examined the role of BM-derived cells expressing an E-type prostaglandin receptor subtype (EP3) in tumor-induced angiogenesis and tumor growth. " 05/01/1979 - "Hypotheses are presented of the detailed molecular structure of two prostaglandin receptors both concerned in tumor-promotion processes. " 01/01/2013 - "Prostaglandin receptor targeting drugs might be beneficial for the treatment of inflammatory, allergic, respiratory and cardiovascular disorders as well as treatment of pain but several novel fields of use such as cancer and ophthalmic diseases have also been found apart from these classical indications. "
3.	Pain (Aches) 05/16/2011 - "Contribution of peripheral versus central EP1 prostaglandin receptors to inflammatory pain." 01/01/2013 - "Prostaglandin receptor targeting drugs might be beneficial for the treatment of inflammatory, allergic, respiratory and cardiovascular disorders as well as treatment of pain but several novel fields of use such as cancer and ophthalmic diseases have also been found apart from these classical indications. " 01/15/2007 - "Behavioral and electrophysiological work in particular with genetically engineered mice meanwhile provides new clues to the role of different prostaglandins, prostaglandin synthases and prostaglandin receptors in pain pathways." 09/01/2005 - "Involvement of cyclooxygenase-2 and EP3 prostaglandin receptor in acute herpetic but not postherpetic pain in mice." 11/01/2002 - "Role of prostaglandin receptor EP1 in the spinal dorsal horn in carrageenan-induced inflammatory pain."
4.	Rupture 01/01/2007 - "There is some circumstantial evidence that prostaglandin F2alpha by action through the prostaglandin receptor subtype FP is effective in key events during labor uterine contraction, rupture of membranes and cervical dilation. "
5.	Hyperalgesia 01/01/2001 - "It is generally thought that the prostaglandin receptor- (especially, the receptor for prostaglandin E(2), EP receptor) mediated sensitization of sensory nerve fibers is a key contributor to the generation of hyperalgesia. " 07/01/2002 - "Effects of a novel selective agonist for prostaglandin receptor subtype EP4 on hyperalgesia and inflammation in monoarthritic model." 01/13/2006 - "In this study we have investigated the role of periaqueductal grey prostaglandin receptors in formalin-induced hyperalgesia in mice. " 09/22/2010 - "This prolongation of PGE2 hyperalgesia in SNS-GRK2+/- mice does not depend on changes in the sensitivity of the prostaglandin receptors because prolonged hyperalgesia also developed in response to 8-Br-cAMP. " 01/13/2006 - "Role of periaqueductal grey prostaglandin receptors in formalin-induced hyperalgesia."

Related Drugs and Biologics

1.	Dinoprost
2.	Prostaglandin-Endoperoxide Synthases (Cyclooxygenase)
3.	Aspirin (Acetylsalicylic Acid)
4.	Formaldehyde (Formol)
5.	Cholecystokinin B Receptor
6.	Protein Isoforms (Isoforms)
7.	Sodium Selenite (Selenite)
8.	Pentylenetetrazole (Metrazol)
9.	Methionine (L-Methionine)
10.	gastrin 17 (G 17)

Related Therapies and Procedures

1.	Ligation
2.	Subcutaneous Injections
3.	Castration