Prolactin Receptors (Prolactin Receptor)

Labile proteins on or in prolactin-sensitive cells that bind prolactin initiating the cells' physiological response to that hormone. Mammary casein synthesis is one of the responses. The receptors are also found in placenta, liver, testes, kidneys, ovaries, and other organs and bind and respond to certain other hormones and their analogs and antagonists. This receptor is related to the growth hormone receptor.

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Networked: 298 relevant articles (2 outcomes, 27 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Smirnova, O V: 11 articles (07/2015 - 01/2002)
2.	Goffin, Vincent: 10 articles (03/2016 - 10/2006)
3.	Walker, Ameae M: 10 articles (09/2015 - 04/2005)
4.	Binart, Nadine: 7 articles (01/2014 - 04/2002)
5.	Clevenger, Charles V: 6 articles (06/2014 - 01/2003)
6.	Chen, Wen Y: 6 articles (02/2013 - 02/2004)
7.	Bogorad, R L: 6 articles (02/2006 - 01/2002)
8.	Vonderhaar, Barbara K: 5 articles (02/2014 - 01/2003)
9.	Schuler, Linda A: 5 articles (12/2013 - 01/2004)
10.	Langenheim, John F: 5 articles (02/2013 - 09/2008)

Related Diseases

1.	Breast Neoplasms (Breast Cancer) 03/01/2013 - "Neutralization of prolactin receptor function by monoclonal antibody LFA102, a novel potential therapeutic for the treatment of breast cancer." 10/07/2005 - "In the present study, we examined the effect of ligand on the endogenous "long" isoform of the prolactin receptor in breast cancer cells. " 04/01/2004 - "This study investigated the presence of any mutation or polymorphism of prolactin receptor (PRLR) in 38 patients with breast cancer. " 09/28/2015 - "Controversy exists concerning the role of the long prolactin receptor (PRLR) in the progression of breast cancer. " 09/28/2015 - "Anti-metastatic outcome of isoform-specific prolactin receptor targeting in breast cancer."
2.	Lymphoma (Lymphomas) 01/01/1982 - "One cultured lymphoma cell line has proved to be a very useful model system in which to examine prolactin receptor synthesis and turnover as well as post-receptor mechanisms of action. " 06/13/1997 - "Cell proliferation activity via prolactin-receptor in Nb-2 lymphoma was obviously low as compared with that of 22K hGH." 12/01/1996 - "Recombinant dPRP failed to bind to PRL receptors and showed no stimulatory activity in the PRL-dependent rat Nb2 lymphoma cell proliferation assay. " 07/01/1990 - "Histochemical and immunocytochemical localization of prolactin receptors on Nb2 lymphoma cells: applications of confocal microscopy." 12/01/1998 - "Prolactin receptor signaling: shared components with the T-cell antigen receptor in Nb2 lymphoma cells."
3.	Neoplasms (Cancer) 02/01/2014 - "This is the largest study to date in which the association of prolactin receptor expression with tumor characteristics has been evaluated. " 02/01/2014 - "The association of prolactin receptor expression with breast tumorigenesis remains unclear as studies that have focused on this association have had limited sample size and/or information about tumor characteristics. " 08/25/1998 - "The aim of this study is to further characterize the prolactin receptors (PRL-R) previously reported in the murine Leydig tumor MA-10 cell line, as well as to study their homologous and heterologous regulation. " 01/01/1985 - "Possible applications include in vitro fertilization and studies on prolactin receptor-bearing tumors." 06/01/2014 - "Many genes that are activated by the prolactin receptor are associated with tumorigenesis and cancer cell proliferation. "
4.	Hyperprolactinemia 02/09/2001 - "The present study aimed to investigate whether increased expression of prolactin receptor (PRL-R) during lactation is caused by suckling-induced hyperprolactinemia or the suckling stimulus itself. " 03/06/2014 - "Mutant prolactin receptor and familial hyperprolactinemia." 03/06/2014 - "Mutant prolactin receptor and familial hyperprolactinemia." 03/06/2014 - "Mutant prolactin receptor and familial hyperprolactinemia." 03/06/2014 - "Mutant prolactin receptor and familial hyperprolactinemia."
5.	Hepatocellular Carcinoma (Hepatoma) 03/01/2007 - "Immunohistochemical study revealed overexpression of prolactin receptors in central and peripheral cells of intrahepatic grafts from H27 rat hepatoma without changes in compartmentalization compared to hepatocytes of intact animals. " 03/01/2007 - "Increase in sex-dependent expression of prolactin receptors after intrahepatic transplantation of H27 rat hepatoma cells." 06/01/2000 - "The aim of this study was to determine the in situ expression of growth hormone receptor (GHR) and prolactin receptor (PRLR) in hepatocellular carcinomas and to compare the results with normal liver. " 06/01/2000 - "Increased expression of growth hormone and prolactin receptors in hepatocellular carcinomas." 01/01/1989 - "With the rat cDNA used as a probe, the prolactin receptor in rabbit mammary gland and human hepatoma cells has also been isolated. "

Related Drugs and Biologics

1.	Prolactin
2.	Hormones
3.	Messenger RNA (mRNA)
4.	Progesterone Receptors (Progesterone Receptor)
5.	Dopamine (Intropin)
6.	9,10-Dimethyl-1,2-benzanthracene (DMBA)
7.	Prolactin Receptors (Prolactin Receptor)
8.	Estrogens (Estrogen)
9.	Progesterone
10.	Somatotropin Receptors (Growth Hormone Receptor)

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Transplants (Transplant)
3.	Transplantation (Transplant Recipients)
4.	Ovariectomy (Oophorectomy)
5.	Isogeneic Transplantation