LH Receptors (LH Receptor)

Those protein complexes or molecular sites on the surfaces and cytoplasm of gonadal cells that bind luteinizing or chorionic gonadotropic hormones and thereby cause the gonadal cells to synthesize and secrete sex steroids. The hormone-receptor complex is internalized from the plasma membrane and initiates steroid synthesis.

Also Known As:

LH Receptor; Receptor, Chorionic Gonadotropin; Receptor, Luteinizing Hormone; Receptors, LH; Chorionic Gonadotropin Receptor; Human Chorionic Gonadotropin Receptor; Luteinizing Hormone Receptor; Receptors, ICSH; Receptors, Interstitial Cell Stimulating Hormone; Receptors, LH-hCG; Receptors, Lutropin; Receptors, hCG; hCG Receptor; Gonadotropin Receptor, Chorionic; Gonadotropin Receptors, Chorionic; Hormone Receptor, Luteinizing; Hormone Receptors, Luteinizing; LH hCG Receptor; LH hCG Receptors; Receptor, LH; Receptor, LH-hCG; Receptor, Lutropin; Receptor, hCG; Receptors, LH hCG; Chorionic Gonadotropin Receptors; Human Chorionic Gonadotropin Receptors; ICSH Receptors; LH-hCG Receptor; LH-hCG Receptors; Luteinizing Hormone Receptors; Lutropin Receptor; Lutropin Receptors; Receptors, Chorionic Gonadotropin; Receptors, Human Chorionic Gonadotropin; Receptors, Interstitial Cell-Stimulating Hormone; Receptors, Luteinizing Hormone; hCG Receptors

Networked: 435 relevant articles (6 outcomes, 43 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Rao, C V: 15 articles (08/2015 - 01/2000)
2.	Huhtaniemi, Ilpo: 12 articles (08/2019 - 01/2003)
3.	Rahman, Nafis A: 9 articles (03/2014 - 04/2004)
4.	Themmen, Axel P N: 8 articles (07/2011 - 08/2002)
5.	Lei, Z M: 8 articles (04/2010 - 01/2000)
6.	Latronico, Ana Claudia: 8 articles (04/2009 - 10/2003)
7.	Ziecik, Adam J: 7 articles (03/2014 - 05/2003)
8.	Verhoef-Post, Miriam: 6 articles (07/2011 - 08/2002)
9.	Li, X: 6 articles (04/2010 - 01/2000)
10.	Rivero-Müller, Adolfo: 5 articles (08/2019 - 10/2004)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2019 - "However, the immunohistochemical studies on the expression of LH/CG receptors (LH/CGR) in the human adrenal cortex and in the adrenocortical tumors are scarce. " 11/01/2000 - "The objective of this study was to examine the distribution and cellular localization of luteinizing hormone receptor (LHR) in ovarian epithelial tumors (OETs) and their presumed precursor lesions-ovarian epithelial inclusions (OEIs). " 01/01/2022 - "Abnormal expression of the GIP, 5-HT7and LH receptors was observed in the APC-mutated adrenocortical tumor tissue. " 11/01/2017 - "Adrenal tumor tissue of two patients showed positive immunohistochemical staining of LH receptors. " 02/01/2016 - "Immunohistochemical staining for the LH/hCG receptor was negative in the tumor tissue and positive in the normal adrenal tissue. "
2.	Adenoma (Adenomas) 05/01/2017 - "Constitutive luteinizing hormone receptor signaling causes sexual dysfunction and Leydig cell adenomas in male mice." 09/01/2001 - "The adenoma tissue contained specific hCG receptors (187 fmol/g). " 01/01/1991 - "(2) The adenoma tissue contained hCG receptors (198 fmol/g). " 07/01/2011 - "Mutation analysis of the LH receptor gene in Leydig cell adenoma and hyperplasia and functional and biochemical studies of activating mutations of the LH receptor gene." 12/16/2019 - "Expression of luteinizing hormone receptor has been reported in aldosterone-producing adenoma. "
3.	Diabetes Mellitus 01/01/2014 - "We have previously demonstrated antibodies in serum against GnRH1 in patients with gastrointestinal dysfunction and diabetes mellitus, and antibodies against GnRH receptor, LH, and LH receptor in patients with infertility. " 01/01/2014 - "The aim of this study was to search for the expression of serum antibodies against GnRH1 with an improved enzyme-linked immune sorbent assay (ELISA), and antibodies against progonadoliberin-2, GnRH2, GnRH receptor, LH, and LH receptor with newly developed ELISAs, in patients with gastrointestinal dysfunction or diabetes mellitus. " 05/01/2021 - "Here we analyzed the effect of a thieno[2,3-d]pyrimidines (TP), 4-((3-(5-amino-6-(tert-butylcarbamoyl)-2-(methylthio)thieno [2,3-d]pyrimidine-4-yl) phenyl)carbamoyl)pyridine 1-oxide (TP22), an allosteric agonist of luteinizing hormone receptors, on the seminiferous tubules and spermatogenic cells in 4- and 18-month-old male rats and in animals with diabetes mellitus. " 01/01/2014 - "Our conclusion was that IgM antibodies against GnRH1, progonadoliberin-2, and/or GnRH receptors were more prevalent in patients with functional gastrointestinal disorders, gastrointestinal dysmotility, and/or diabetes mellitus, whereas IgG antibodies against these peptides, and LH- and LH receptor antibodies, were expressed in the same magnitude as in controls. "
4.	Acth-Independent Macronodular Adrenal Hyperplasia 12/01/2007 - "GIP and LH-receptor expression may coexist in AIMAH, influencing the functional and morphological phenotype. " 05/01/2013 - "We focused on the efficacy of somatostatin analogues in a patient with food-dependent AIMAH and of leuprolide acetate in a patient with AIMAH due to aberrant LH/hCG receptor expression. "
5.	Rupture 03/01/1996 - "However, 48 h after follicular rupture there as a marked decrease in overall labelling with anti-LH receptor antibody, and especially a disappearance of immunostaining in the luteal cells of granulosa origin. "

Related Drugs and Biologics

1.	Luteinizing Hormone (Lutropin)
2.	Chorionic Gonadotropin (Human Chorionic Gonadotropin)
3.	Enzymes
4.	Gonadotropin-Releasing Hormone (GnRH)
5.	Antibodies
6.	LHRH Receptors (Gonadotropin-Releasing Hormone Receptor)
7.	Cytochrome P450 Family 11
8.	Leuprolide (Lupron)
9.	Steroid 11-beta-Hydroxylase (11 beta-Hydroxylase)
10.	Somatostatin (Somatotropin Release-Inhibiting Factor)

Related Therapies and Procedures

1.	Therapeutics
2.	Punctures
3.	Anesthesia
4.	Lasers (Laser)
5.	Subcutaneous Injections