LDL Receptors (LDL Receptor)

Receptors on the plasma membrane of nonhepatic cells that specifically bind LDL. The receptors are localized in specialized regions called coated pits. Hypercholesteremia is caused by an allelic genetic defect of three types: 1, receptors do not bind to LDL; 2, there is reduced binding of LDL; and 3, there is normal binding but no internalization of LDL. In consequence, entry of cholesterol esters into the cell is impaired and the intracellular feedback by cholesterol on 3-hydroxy-3-methylglutaryl CoA reductase is lacking.

Also Known As:

Networked: 3829 relevant articles (115 outcomes, 424 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Daugherty, Alan: 28 articles (01/2022 - 03/2002)
2.	Van Eck, Miranda: 21 articles (10/2022 - 09/2004)
3.	Fazio, Sergio: 21 articles (01/2021 - 04/2002)
4.	Seidah, Nabil G: 21 articles (10/2020 - 06/2003)
5.	Rader, Daniel J: 21 articles (01/2019 - 09/2002)
6.	Defesche, Joep C: 19 articles (03/2018 - 12/2002)
7.	Hoekstra, Menno: 18 articles (10/2022 - 10/2006)
8.	Kuiper, Johan: 18 articles (12/2021 - 12/2005)
9.	Kastelein, John J P: 18 articles (01/2019 - 12/2002)
10.	Van Berkel, Theo J C: 17 articles (01/2021 - 04/2002)

Related Diseases

1.	Atherosclerosis 04/30/2007 - "These results show for the first time that this dual Tx inhibitor is effective in reducing atherogenesis in the LDL receptor deficient mice. " 09/01/2011 - "Macrophage Elovl6 deficiency ameliorates foam cell formation and reduces atherosclerosis in low-density lipoprotein receptor-deficient mice." 12/17/2021 - "To study whether and how the Tc17 subset affects atherosclerosis, we performed an adoptive transfer of Tc17 cells or undifferentiated Tc0 cells into CD8-/- low-density lipoprotein receptor-deficient mice fed a Western-type diet. " 01/01/2021 - "In this study, we investigated the anti-atherosclerosis effect of CM1 and the underlying mechanisms of action in a low-density lipoprotein receptor knockout (LDLR(-/-) mouse model. " 10/01/2020 - "This study investigated the effects of BM diet-induced atherosclerosis in LDL receptor-deficient mice. "
2.	Hypercholesterolemia 01/01/2006 - "Upregulation of liver LDL receptor expression is effective in treating hypercholesterolemia. " 06/13/2022 - "In the pharmacodynamic study, low-density lipoprotein receptor-deficient (LDLr-/-) mice were fed with a high-fat diet (HFD) for two weeks to establish a mouse model of hypercholesterolemia. " 01/01/2015 - "Although ARH has been described as being "recessive," several studies, including ours, have indicated that a heterozygous carrier status of the LDLRAP1 gene is associated with mild hypercholesterolemia and exacerbates the phenotype of FH resulting from LDL receptor gene mutations. " 09/01/2014 - "This challenging work in the genetics of hypercholesterolemia paved the way for a plethora of studies around the world allowing the characterization of PCSK9, its expression, its impact on reducing the abundance of LDL receptor, and the identification of loss-of-function mutations in hypocholesterolemia. " 01/01/2009 - "This study utilized a mouse model of hypercholesterolemia, low-density lipoprotein receptor knockout (LDLr(-/-)) mice fed a high-fat diet for 5 months, to test the hypothesis that farnesoid X receptor (FXR) deficiency contributed to NASH development. "
3.	Hyperlipoproteinemia Type II (Familial Hypercholesterolemia) 01/01/2020 - "Approach and Results: Six healthy controls, 9 heterozygous patients with familial hypercholesterolemia (5 with low-density lipoprotein receptor [LDLR] mutations and 4 with PCSK9 gain-of-function mutations) and 3 patients with heterozygous dominant-negative PCSK9 loss-of-function mutations were included in the preliminary study. " 01/01/2015 - "This study aimed to investigate the exact prevalence of familial hypercholesterolemia (FH) in the general population, taking advantage of the fact that five low-density lipoprotein receptor (LDLR) founder mutations account for 78% of FH cases in Finland. " 02/01/2009 - "The objective of this study was to develop a new and simple method for measuring low-density lipoprotein receptor (LDLR) activity using peripheral lymphocytes enabling us to clinically diagnose familial hypercholesterolemia (FH) and ascertain the involved mutations (such as K790X mutation), that might not be clearly detected in the conventional method. " 11/01/2003 - "The current study sought to investigate the role of low-density lipoprotein receptor (LDLr) mutations in assessing the risk profile of familial hypercholesterolemia (FH) patients, independently of major cardiovascular risk factors. " 07/01/1999 - "Genetic studies reveal familial hypercholesterolemia to be a dysfunction of LDL receptor gene on cell surface. "
4.	Hyperlipidemias (Hyperlipidemia) 06/01/2023 - "This study aimed to investigate whether CM3-SII could ameliorate hyperlipidemia in a heterozygous low-density lipoprotein receptor (LDLR)-deficient hamster model of hyperlipidemia. " 07/01/2012 - "The objective of this study was to evaluate the effect of hyperlipidemia on the biomechanical and morphological properties of the femur of low-density lipoprotein receptor gene knockout mice (LDLr-/-) mice. " 10/01/2003 - "Molecular analysis of the LDL receptor gene will clearly identify the cause of the patient's hyperlipidemia and allow appropriate early treatment as well as antenatal and family studies." 10/05/2001 - "In the current study, we show an unexpectedly severe hyperlipidemia in ob/ob mice on a background of low density lipoprotein receptor (LDLR) deficiency (-/-). " 01/01/2023 - "We additionally induced hyperlipidemia in young and old C57BL/6 mice by adeno-associated virus mediated upregulation of LDL receptor regulator, Pcsk9, and 5 weeks of AD. "
5.	Homozygous Familial Hypercholesterolemia 07/01/2021 - "On the other hand, the action an MTP inhibitor is independent of LDL receptor activity, and it is effective in most HoFH cases.This" 07/01/2023 - "Gene therapy is an appealing treatment option as restoration of low-density lipoprotein receptor (LDLR) gene function could provide a cure for HoFH. " 10/01/2006 - "ARH is a phenocopy of homozygous familial hypercholesterolemia (HoFH) due to mutations in LDL receptor (LDLR) gene; however, previous studies suggested that ARH phenotype is less severe than that of HoFH. " 02/01/1999 - "The aim of this study was the characterization of mutations of the LDL receptor gene in 39 Italian patients with homozygous familial hypercholesterolemia, who were examined during the period 1994 to 1996. " 08/01/1986 - "LDL receptor studies showed 3% of normal binding activity, which defines the receptor-negative form of homozygous familial hypercholesterolemia (FH). "

Related Drugs and Biologics

1.	oxidized low density lipoprotein
2.	Cholesterol
3.	LDL Lipoproteins (beta Lipoproteins)
4.	Apolipoproteins
5.	Lipoproteins (Lipoprotein)
6.	Proteins (Proteins, Gene)
7.	LDL Cholesterol
8.	Lipids
9.	Apolipoprotein A-I (Apolipoprotein A1)
10.	Apolipoproteins B (ApoB)

Related Therapies and Procedures

1.	Therapeutics
2.	Blood Component Removal (Apheresis)
3.	Liver Transplantation
4.	Transplantation
5.	Bone Marrow Transplantation (Transplantation, Bone Marrow)