Histamine Receptors (Histamine Receptor)

Cell-surface proteins that bind histamine and trigger intracellular changes influencing the behavior of cells. Histamine receptors are widespread in the central nervous system and in peripheral tissues. Three types have been recognized and designated H1, H2, and H3. They differ in pharmacology, distribution, and mode of action.

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Networked: 435 relevant articles (18 outcomes, 55 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Watanabe, Takeshi: 8 articles (09/2013 - 07/2002)
2.	Tanimoto, Akihide: 6 articles (02/2015 - 02/2005)
3.	Sasaguri, Yasuyuki: 6 articles (02/2015 - 02/2005)
4.	Wang, Ke-Yong: 6 articles (02/2015 - 02/2005)
5.	Ohtsu, Hiroshi: 6 articles (10/2014 - 01/2006)
6.	Cai, Wen-Ke: 4 articles (07/2015 - 09/2012)
7.	Yamada, Sohsuke: 4 articles (02/2015 - 08/2010)
8.	Thurmond, Robin L: 4 articles (01/2015 - 11/2004)
9.	He, Gong-Hao: 4 articles (01/2015 - 09/2012)
10.	Czuczwar, Stanisław J: 4 articles (06/2014 - 07/2005)

Related Diseases

1.	Hypersensitivity (Allergy) 12/01/2012 - "These include new histamine receptor antagonists, combination therapy and strategies to selectively block relevant signaling pathways of the allergic reaction. " 01/01/2012 - "Blockage of histamine receptor subtypes could prevent the excess mucus production associated with ocular allergy." 11/01/2005 - "Histamine receptors play an important role in the pathogenesis of nasal allergy. " 01/01/1993 - "Influence of histamine receptor antagonists on the dynamics of the cutaneous hypersensitivity reaction in patients infected with schistosoma haematobium." 08/01/1983 - "However, the participation of histamine receptors on dermal mast cells in the immediate skin allergic reaction is still left inconclusive."
2.	Hypotension (Low Blood Pressure) 08/01/1975 - "The result of this study suggested a predominance of H1 and some H2 histamine receptors in the cardiovascular system of domestic fowl where both are mediating systemic hypotension. " 01/01/1995 - "These data suggest that NPY (27-36)-D produces a profound and sustained hypotension in two strains of rat which is partially attributable to activity at histamine receptors." 11/01/1992 - "An antagonist to H1 histamine receptor and one to H2 histamine receptor were used to prevent protamine-induced hypotension in 126 Japanese patients undergoing open heart surgery. " 12/01/1981 - "These data suggest that the maintenance of adrenal blood flow during hemorrhagic hypotension to 50 mmHg MABP is independent of the autonomic nervous system, prostaglandin synthesis, histamine receptors, or an intact pituitary-adrenal axis, even though all of these systems do influence adrenal blood flow." 02/01/1989 - "A prospective randomized study was undertaken to evaluate the use of histamine-receptor blockade to prevent protamine-induced hypotension in patients undergoing elective aortocoronary artery bypass graft surgery. "
3.	Ulcer 10/01/1989 - "The marked reduction in elective ulcer operations observed in our institution may be due to several factors, including better nonoperative therapy (eg, histamine receptor antagonists), physician preference for nonoperative treatment of chronic ulcers, or a reduced incidence of chronic ulcer within our population. " 01/01/2004 - "The effects of several histamine receptor antagonists on this ulcer model also were evaluated. " 01/01/1998 - "Roles of histamine receptors and oxyradicals in aggravation of acid-induced gastric haemorrhagic ulcers in endotoxaemic rats." 09/01/1983 - "Inhibitory effects of histamine receptor antagonist on stress ulcer." 05/01/1992 - "Bleeding asymptomatic ulcers are frequent and respond to H2 histamine receptor antagonists."
4.	Anaphylaxis (Anaphylactic Shock) 10/01/2013 - "Here, we sought to define the necessity for histamine receptors in the pathology of anaphylaxis using H1R and H2R knockout (KO) mice, as well as a H1R/H2R double KO strain. " 02/01/2002 - "H1 and H2 histamine receptor subtypes are present throughout the heart and may be involved in disturbances of cardiac rhythm that occur during anaphylaxis. " 12/01/1989 - "Pretreatment with either the inhibitor of LT synthesis or the histamine receptor antagonist reduced the lethality during anaphylactic shock from 100 to 60 and 78%, respectively. " 06/01/1984 - "[Histamine receptors and clinical expression of some anaphylactic reactions]." 10/01/1982 - "Are the prejunctional histamine receptors on sympathetic nerve terminals in guinea-pig isolated atria activated during anaphylaxis in vitro?"
5.	Allergic Conjunctivitis (Giant Papillary Conjunctivitis) 10/01/2011 - "Our aim was to evaluate histamine receptor expression in normal and vernal keratoconjunctivitis conjunctiva. " 01/01/1999 - "Olopatadine is a dual acting H1 histamine receptor antagonist and a mast cell stabilizer, shown to be effective in treating allergic conjunctivitis. " 09/01/2006 - "We investigated the early efficacy of topical levocabastine, an H(1) histamine-receptor antagonist, in improving the clinical symptoms of allergic conjunctivitis. " 12/01/2012 - "Olopatadine is both a H1 histamine receptor antagonist and a mast cell stabilizer, indicated for the treatment of allergic conjunctivitis. " 09/01/2005 - "Histamine receptor activation and degranulation of mast cells are the mechanisms by which the ocular itching, hyperemia, chemosis, eyelid swelling, and tearing of seasonal allergic conjunctivitis are induced. "

Related Drugs and Biologics

1.	Proton Pump Inhibitors
2.	Histamine (Histamine Dihydrochloride)
3.	Antacids
4.	Histamine Antagonists (Antihistamines)
5.	Heparin (Liquaemin)
6.	1-phenyl-3,3-dimethyltriazene (PDT)
7.	Serotonin (5 Hydroxytryptamine)
8.	Ovalbumin
9.	Allergens
10.	olopatadine (Patanol)

Related Therapies and Procedures

1.	Transplants (Transplant)
2.	Ligation
3.	Oral Surgery (Maxillofacial Surgery)
4.	Lasers (Laser)
5.	Injections