Fc Receptors (Fc Receptor)

Molecules found on the surface of some, but not all, B-lymphocytes, T-lymphocytes, and macrophages, which recognize and combine with the Fc (crystallizable) portion of immunoglobulin molecules.

Also Known As:

Networked: 1309 relevant articles (41 outcomes, 119 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Takai, Toshiyuki: 17 articles (01/2014 - 02/2002)
2.	Verbeek, J Sjef: 12 articles (03/2015 - 10/2002)
3.	Ravetch, Jeffrey V: 11 articles (05/2015 - 06/2002)
4.	Kleinau, Sandra: 9 articles (01/2015 - 10/2002)
5.	Nimmerjahn, Falk: 8 articles (05/2015 - 03/2006)
6.	Hogarth, P Mark: 6 articles (01/2014 - 12/2002)
7.	Nakamura, Akira: 6 articles (01/2014 - 02/2002)
8.	Levy, Ronald: 6 articles (11/2011 - 12/2004)
9.	van de Winkel, J G: 6 articles (10/2001 - 04/2000)
10.	van Egmond, Marjolein: 5 articles (11/2015 - 05/2005)

Related Diseases

1.	Neoplasms (Cancer) 07/01/1996 - "These results showed that, even though the bivalent mAb 1.1ASML did not mediate stable cross-linking of target and effector cells, its Fc-receptor-mediated killing of tumor cells was more effective when compared to the BAC. " 11/15/1990 - "and decreased Fc receptor-mediated binding, demonstrated improved tumor:tissue ratios as compared to intact antibody HA. " 02/01/2015 - "Our studies demonstrate that modifications that abrogate binding to Fc receptors are crucial for CARs in which a long spacer is obligatory for tumor recognition as shown here for a ROR1-specific CAR. " 06/01/2014 - "The present study further confirms ADCC as the mechanism by which H10-03-6 mediates tumor cell killing, since H10-03-6 was shown to interact simultaneously with Her-2/neu and the Fc receptor CD16a. " 11/15/1987 - "Overall, these studies have demonstrated the specificity of Fc receptors in triggering monocyte- and granulocyte-mediated antibody-dependent tumor cell killing and have begun to dissect functional similarities and differences among the three defined Fc gamma R on human myeloid cells."
2.	Infection 06/15/2001 - "Fc receptor-mediated phagocytosis makes a significant contribution to clearance of influenza virus infections." 02/01/1989 - "Thus, the Fc receptor is an attractive candidate for application in the diagnosis of, or protection against, infections with S. " 06/15/2001 - "We conclude that Fc receptor-mediated phagocytosis plays a pivotal role in clearance of respiratory virus infections." 04/01/1993 - "Infection of primary macrophages in vitro by feline infectious peritonitis virus (FIPV) was used as a model system to study the kinetics of Fc receptor-mediated antibody-dependent enhancement (FcR-ADE) of virus infectivity at the single cell level. " 03/01/1992 - "Studies of antibody-dependent enhancement of human immunodeficiency virus (HIV) type 1 infection mediated by Fc receptors using sera from recipients of a recombinant gp160 experimental HIV-1 vaccine."
3.	Autoimmune Diseases (Autoimmune Disease) 12/01/2013 - "Previous studies have identified several single nucleotide polymorphisms (SNPs) of Fc receptor-like 3 (FCRL3), an excellent susceptibility gene, as predisposing factors for human autoimmune diseases (ADs). " 10/01/2012 - "Previous studies have found that the Fc receptor-like (FCRL) molecule, involved in controlling B cell signaling, may contribute to the autoimmune disease process. " 08/15/2005 - "Genetic studies in mice indicate a crucial role for Fc receptors (FcR) in antibody-mediated autoimmune diseases. " 07/01/2005 - "While the recognition site on Fab is unknown, comparative binding studies with Fc, in association with the striking similarities of the peptide (named Fc-receptor mimetic, FcRM) with a region of the human FcgammaRIII receptor, strongly indicate that the peptide could recognize a short amino acid stretch of the lower hinge region, which has a key role in autoimmune disease triggering. " 01/01/1985 - "In vitro study of Fc-receptor function in autoimmune diseases."
4.	Systemic Lupus Erythematosus (Libman-Sacks Disease) 06/01/1987 - "Reticuloendothelial system Fc receptor function in systemic lupus erythematosus: effect of decreased sensitization on clearance of autologous erythrocytes." 12/01/1989 - "Nuclear imaging and the assessment of human Fc receptor function: studies in systemic lupus erythematosus." 02/01/1983 - "Studies in patients with active systemic lupus erythematosus show a profound defect in Fc-receptor-specific clearance that correlates with disease activity. " 01/01/1982 - "A serial study of reticuloendothelial system splenic Fc receptor function was undertaken in 13 patients with systemic lupus erythematosus (SLE). " 01/01/1982 - "A serial study of splenic reticuloendothelial system Fc receptor functional activity in systemic lupus erythematosus."
5.	Inflammation 01/01/2009 - "The goal of this study was to determine whether expression of Fc receptor (FcgammaR) I on circulating monocytes is associated with systemic inflammation and renal disease in SLE patients. " 04/01/1995 - "It is now possible to study the function of Fc gamma RIIIa and other gamma chain associated Fc receptors in the initiation and progression of chronic glomerular inflammation in the context of the intact immune system in vivo." 11/01/2015 - "Thus, Fcα/μR is a unique Fc receptor that is involved in humoral immune responses and inflammation. " 12/16/2014 - "Their role, and that of the fragment crystallizable (Fc) receptors that bind them, in driving local inflammation is not fully understood. " 10/01/2013 - "One of the negative outcomes of retained surface Ig is exacerbation of inflammation by leucocyte Fc receptor (FcR) activation, with consequences ranging from inflammatory cytokine and ROS release to chronic inflammation. "

Related Drugs and Biologics

1.	Immunoglobulin G (IgG)
2.	Antibodies
3.	Antigen-Antibody Complex (Immune Complex)
4.	Immunoglobulin E (IgE)
5.	Inosine Triphosphate (ITP)
6.	tranilast (N 5')
7.	Antigens
8.	Immunoglobulins (Immunoglobulin)
9.	rituximab (Mabthera)
10.	trastuzumab (Herceptin)

Related Therapies and Procedures

1.	Heterologous Transplantation (Xenotransplantation)
2.	Immunotherapy
3.	Ligation
4.	Drug Therapy (Chemotherapy)
5.	Continuous Ambulatory Peritoneal Dialysis (CAPD)