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Estrogen Receptors

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Cytoplasmic proteins that bind estrogens and migrate to the nucleus where they regulate DNA transcription. Evaluation of the state of estrogen receptors in breast cancer patients has become clinically important.

Also Known As:

Receptors, Estrogen; Estrogen Nuclear Receptor; Estrogen Receptor Type I; Estrogen Receptor Type II; Estrogen Receptors Type I; Estrogen Receptors Type II; Receptor, Estrogen Nuclear; Receptors, Estrogen, Type I; Receptors, Estrogen, Type II; Nuclear Receptor, Estrogen

Networked: 2437 relevant articles (49 outcomes, 239 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins
- Proteins: 90489

Experts

1.	Choi, Kyung-Chul: 10 articles (11/2015 - 06/2011)
2.	Gustafsson, Jan-Ake: 10 articles (08/2011 - 06/2002)
3.	Hwang, Kyung-A: 8 articles (04/2015 - 06/2011)
4.	Katzenellenbogen, John A: 7 articles (11/2013 - 04/2006)
5.	Pietras, Richard J: 7 articles (04/2008 - 05/2005)
6.	Sasano, Hironobu: 6 articles (10/2012 - 03/2008)
7.	Chaudry, Irshad H: 6 articles (03/2009 - 03/2003)
8.	Jordan, V Craig: 5 articles (06/2015 - 03/2004)
9.	Ye, Qinong: 5 articles (08/2014 - 12/2005)
10.	Gustafsson, Jan-Åke: 5 articles (03/2014 - 01/2012)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2014 - "Since more than 75% of breast cancers overexpress estrogen receptors (ER), endocrine therapy targeting ER has significantly improved the survival rate. " 01/01/2011 - "Cancer patients with positive estrogen receptors (ERs) had significantly greater concentration of breast tissue Cd compared to patients with negative ERs (P = 0.035). " 05/01/1999 - "Tumor size, number of lymph nodes, estrogen receptors, menopausal status at diagnosis, and disease-free interval at the initiation of the observation period were comparable for the trial participants (n = 62) versus nonparticipants (n = 257) and for women on ERT (n = 39) versus controls (n = 280). " 01/01/1999 - "Using the generalized Wilcoxon test and the Cox proportional hazards regression model, patients with tumors that demonstrated estrogen receptors had an improved DFS (P=0.03). " 04/15/1981 - " 53% of the primary and 32% of the secondary tumors gave positive results when tested for the presence of estrogen receptors. "
2.	Breast Neoplasms (Breast Cancer) 08/01/1982 - "It has been observed that 60-70% of breast cancer patients have estrogen receptors (ER) and that nearly two-thirds of such patients respond favorably to endocrine therapy. " 10/01/2014 - "The objective of this study was to investigate the differential regulation of estrogen receptors (ERs) α and β as a potential mechanism of inhibition of breast cancer by HPIMBD. " 07/01/2013 - "Our aim was to study the effects of 17β-estradiol on mitochondrial biogenesis, dynamics and function in breast cancer cell lines with different estrogen receptors ratios. " 07/01/2011 - "In vitro cell uptake studies were carried out in breast cancer cells MCF7, overexpressing estrogen receptors. " 05/01/2008 - "In this study, the involvement of estrogen receptors (ER) in these events was evaluated in three human breast cancer cell lines, MCF-7, MDA-MB-231, and SK-BR-3. "
3.	Carcinoma (Carcinomatosis) 10/01/2000 - "We have carried out the present study in order to analyze the clinical-biological impact of pS2 positivity (>2 ng/mg prt.) in negative estrogen receptors (< 10 fmol/mg prt.) infiltrating ductal breast carcinomas (IDC). " 06/01/1992 - "Densitometric and morphometric study of immunocytochemical estrogen receptors detection in breast carcinomas." 01/01/1987 - "[Correlation of histopathologic and immunohistochemical data (using the D5 antibody) and biochemical analysis in the study of estrogen receptors in breast carcinoma]." 01/01/1987 - "[Immunocytochemical demonstration and morphometric study by image analysis of estrogen receptors in carcinoma of the breast: study of 30 cases]." 08/01/2015 - "The sharp decline of beta estrogen receptors expression in long-lasting ulcerative-associated carcinoma."
4.	Neoplasm Metastasis (Metastasis) 12/01/2000 - "The following clinical and pathological characteristics have been analyzed and compared: age, menopausal status, clinical axillar node involvement, symptoms duration before diagnosis, grade, estrogen receptors, presence of metastases at diagnosis, local recurrence, metastasic dissemination, disease-free (DFS) and overall survival (OS). " 04/01/2015 - "Metastasis-associated protein 1 (MTA1) and its short form (MTA1s) regulate the function of estrogen receptors (ERs). " 04/01/2015 - "Expression and subcellular localization of metastasis-associated protein 1, its short form, and estrogen receptors in rat placenta." 05/01/2009 - "Expression of HspBP1 was significantly lower in patients with lymph node metastasis and positive for estrogen receptors. " 10/01/2007 - "Presence of visceral metastases, multiplicity of bony lesions, presence of estrogen receptors (ER), and segment of spine (cervical, thoracic, lumbar, sacral) in which metastases arose were compared with patient survival. "
5.	Inflammation 01/01/2012 - "The overall objectives of this thesis were to study the functional importance of estrogen receptors in the periodontium with special focus on inflammation, and stimulators of inflammation and their signaling pathways. " 07/21/2015 - "The orphan nuclear receptor estrogen-related receptor α (ERRα; NR3B1) is a key metabolic regulator, but its function in regulating inflammation remains largely unknown. " 01/01/2015 - "Estrogen receptors mediate numerous favorable effects on cells and molecules implicated in vascular inflammation and atherogenic process. " 01/01/2015 - "Vascular Inflammation and Atherosclerosis: The Role of Estrogen Receptors." 01/01/2013 - "The sexually dimorphic role of adipose and adipocyte estrogen receptors in modulating adipose tissue expansion, inflammation, and fibrosis."

Related Drugs and Biologics

1.	Estrogens (Estrogen)
2.	Progesterone Receptors (Progesterone Receptor)
3.	Hormones
4.	Tamoxifen
5.	Estrogen Receptor Modulators (Antiestrogen)
6.	Estradiol (Estrace)
7.	Androgen Receptors (Androgen Receptor)
8.	letrozole (Femara)
9.	Aromatase (CYP19)
10.	Estrogen Receptor beta

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Mastectomy (Mammectomy)
3.	Mammaplasty (Breast Reconstruction)
4.	Segmental Mastectomy (Lumpectomy)
5.	Radiotherapy