A cell surface receptor involved in regulation of cell growth and differentiation. It is specific for EPIDERMAL GROWTH FACTOR and EGF related peptides including TRANSFORMING GROWTH FACTOR ALPHA, amphiregulin, and heparin-binding EGF-like growth factor. The binding of ligand to the receptor causes activation of its intrinsic tyrosine kinase activity and rapid internalization of the receptor-ligand complex into the cell.
Also Known As:
EGF Receptor; Receptor, Epidermal Growth Factor; Epidermal Growth Factor Receptor Kinase; Receptors, Epidermal Growth Factor; Epidermal Growth Factor Receptor Protein Tyrosine Kinase; Proto-Oncogene Protein, erbB-1; Receptor, TGF alpha; Receptor, Transforming Growth Factor alpha; Receptors, Epidermal Growth Factor Urogastrone; c erbB 1 Protein; erbB 1 Proto Oncogene Protein; Epidermal Growth Factor Receptor Protein-Tyrosine Kinase; Receptor, EGF; Receptor, TGF-alpha; Receptor, Transforming-Growth Factor alpha; Receptor, Urogastrone; Receptors, Epidermal Growth Factor-Urogastrone; TGF-alpha Receptor; Transforming Growth Factor alpha Receptor; Urogastrone Receptor; c-erbB-1 Protein; erbB-1 Proto-Oncogene Protein