T-Cell Antigen Receptors (T-Cell Receptor)

Molecules on the surface of T-lymphocytes that recognize and combine with antigens. The receptors are non-covalently associated with a complex of several polypeptides collectively called CD3 antigens (ANTIGENS, CD3). Recognition of foreign antigen and the major histocompatibility complex is accomplished by a single heterodimeric antigen-receptor structure, composed of either alpha-beta (RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA) or gamma-delta (RECEPTORS, ANTIGEN, T-CELL, GAMMA-DELTA) chains.

Also Known As:

Networked: 4620 relevant articles (73 outcomes, 383 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Rosenberg, Steven A: 43 articles (12/2015 - 02/2004)
2.	Morgan, Richard A: 29 articles (03/2015 - 04/2005)
3.	Vandenbark, Arthur A: 27 articles (10/2014 - 01/2002)
4.	Offner, Halina: 26 articles (02/2015 - 01/2002)
5.	Li, Yangqiu: 23 articles (09/2015 - 01/2002)
6.	Restifo, Nicholas P: 22 articles (04/2015 - 02/2004)
7.	Chen, Shaohua: 21 articles (09/2015 - 01/2002)
8.	Burrows, Gregory G: 20 articles (02/2013 - 09/2004)
9.	Yang, Lijian: 19 articles (07/2015 - 01/2002)
10.	Robbins, Paul F: 15 articles (12/2015 - 03/2005)

Related Diseases

1.	Neoplasms (Cancer) 09/01/2015 - "Adoptive transfer of T cells redirected by a high-affinity antitumor T-cell receptor (TCR) is a promising treatment modality for cancer patients. " 06/01/2015 - "Adoptive T cell therapies based on introduction of new T cell receptors (TCRs) into patient recipient T cells is a promising new treatment for various kinds of cancers. " 07/01/2004 - "The use of gene-engineered T cells expressing chimeric single-chain (scFv) receptors capable of codelivering CD28 costimulation and T cell receptor zeta chain (TCR-zeta) activation signals has emerged as a promising treatment regimen for cancer. " 05/06/1994 - "The enrichment of human T cells within the tumor and the fact that established tumors can be cured may indicate in situ activation of both the T cell receptor and the costimulatory pathway." 09/01/2012 - "CTL-specific T-cell receptor (TCR) transcripts could be detected by quantitative PCR analysis in both peripheral blood and BM during tumor remission. "
2.	Experimental Autoimmune Encephalomyelitis (Encephalomyelitis, Autoimmune Experimental) 02/22/2005 - "Epicutaneous immunization of T cell receptor (TCR) transgenic (Tg) mice whose CD4(+) T cells are specific for the Ac1-11 fragment of myelin basic protein (MBP) with Ac1-11 elicits T cells with dominant suppressor/regulatory activity that confers protection against Ac1-11-induced experimental autoimmune encephalomyelitis. " 06/15/1996 - "Exploitation of the Vbeta8.2 T cell receptor in protection against experimental autoimmune encephalomyelitis using a live vaccinia virus vector." 03/03/2009 - "To study the role of CTLA-4 in the control of experimental autoimmune encephalomyelitis (EAE), we have generated a CTLA-4KO mouse in which >90% of all CD4(+) T cells bear a Vbeta8.2 transgenic T-cell receptor that is specific for myelin basic protein peptide Ac1-9 (ASQKRPSQR). " 01/01/2002 - "The aim of this study was to identify immune-related genes affected by treatment with 17beta-estradiol (17beta-E2) that contribute to protection of T cell antigen receptor double transgenic mice from experimental autoimmune encephalomyelitis (EAE). " 08/01/1995 - "Studies on T-cell receptors involved in experimental autoimmune encephalomyelitis using the complementary peptide recognition approach."
3.	Infection 04/01/2007 - "The cis isomers were found to have significantly greater efficacy in both preventing and curing infection in a mouse model than the trans polyamine analogues when tested in a T-cell receptor alpha-deficient mouse model. " 02/01/2003 - "Our studies in NKT-cell-deficient, T-cell receptor Jalpha281 gene-targeted mice have established that classical NKT cells do not play a critical role in the early clearance of MCMV infection. " 12/01/1994 - "This short review recalls those heady days and briefly recounts some of the later findings in three aspects of particular interest raised by the original finding: the nature of the T cell receptor, the composition and structure of the ligand on the target cell recognized by the TCR and the importance of CTL in the control and clearance of infections in general." 01/01/2015 - "From the microarray studies, genes that exhibited significant (greater than 1.5-fold, false discovery rate <0.05) changes in expression in thymus and bone marrow on CAV infection were mainly associated with T-cell receptor signalling, immune response, transcriptional regulation, intracellular signalling and regulation of apoptosis. " 02/01/2013 - "Because signaling through Slam family receptors can affect innate immunity [natural killer T cell (NKT) and γ-δ T-cell receptor], and innate immunity can determine susceptibility to coxsackievirus B3 (CVB3) infection, the present study evaluated the response of C57Bl/6 and congenic B6.129c1 mice (expressing the 129-derived Slam locus) to CVB3. "
4.	Leukemia 07/01/2009 - "Our previous study showed skewed expression of T cell receptor beta variable region (TRBV) subfamilies and clonal expansion of T cells in leukemia patients. " 11/01/2005 - "In this study we have used retroviral gene transfer to introduce a WT1-specific T-cell receptor (TCR) into T lymphocytes obtained from patients with leukemia and from healthy donors. " 05/01/1993 - "Lineage promiscuity in leukemia studies of T-cell receptor and immunoglobulin genes." 01/01/1986 - "Recent studies (16-18) examining T cell antigen receptor gene rearrangement and expression in certain IL-2-dependent NK cell lines and leukemias have revealed that some lines rearrange C beta genes, whereas others do not. " 07/01/2015 - "Inducible T-cell receptor expression in precursor T cells for leukemia control."
5.	Inflammation 01/01/1999 - "Support for this model has come from studies in T cell receptor (TCR) transgenic animals which develop inflammation of the synovial membrane stimulated by a T cell response to ubiquitously expressed self-MHC molecules. " 02/01/1991 - "Previous studies have suggested that the T cell receptor (TcR) repertoire of these cells is restricted, reflecting in vivo selection of a limited number of T cell specificities at the site of inflammation. " 12/01/2015 - "Increased inflammation within the lamina propria was seen in 7 cases, and increased intraepithelial lymphocytes within crypts was seen in 8 cases; the lymphocytes were mostly T cells with a predominance of CD8 T cells, with the majority expressing the α/β T-cell receptor. " 05/01/2015 - "We investigated the role or roles of HDAC6 in CD8 T-cell activation and functions during skin inflammation in vitro and in vivo and examined the mechanism by which HDAC6 inhibition modifies T-cell receptor signaling in vitro. " 06/01/2014 - "Activation of IGF2R and T-cell receptor induced marked Treg cell proliferation and release of TGF-β from Treg cells, which enhanced Treg cell immune suppressor effects on other Teff cell activities and allergic inflammation in the intestine. "

Related Drugs and Biologics

1.	Antigens
2.	DNA (Deoxyribonucleic Acid)
3.	Peptides
4.	Antigen Receptors (Antigen Receptor)
5.	alpha-beta T-Cell Antigen Receptors (T-Cell Receptor alpha-Chain)
6.	Monoclonal Antibodies
7.	Indicators and Reagents (Reagents)
8.	Immunoglobulins (Immunoglobulin)
9.	Ligands
10.	Proteins (Proteins, Gene)

Related Therapies and Procedures

1.	Immunotherapy
2.	Ligation
3.	Drug Therapy (Chemotherapy)
4.	Tissue Therapy (Cell Therapy)
5.	Aftercare (After-Treatment)